Adverse events following first and second dose COVID-19 vaccination in England, October 2020 to September 2021: a national vaccine surveillance platform self-controlled case series study

Review Biochemistry & Molecular Biology

Covid-19 vaccines and neurological complications: a systematic review

Fakhri Allahyari et al.

Summary: COVID-19 vaccines may lead to neurological complications, but the advantages of vaccination outweigh the risks. Further research is needed to understand the relationship between neurological complications and COVID-19 vaccines.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES (2023)

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Editorial Material Infectious Diseases

Rapid evaluation of the safety of COVID-19 vaccines: how well have we done? Comment

Elizabeth Miller

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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Article Infectious Diseases

Pfizer-BioNTech and Oxford AstraZeneca COVID-19 vaccine effectiveness and immune response amongst individuals in clinical risk groups

Heather J. Whitaker et al.

Summary: This study evaluated the antibody response and effectiveness of COVID-19 vaccines among individuals in clinical risk groups using GP electronic health record data, virology swabbing, and antibody testing. The findings showed that most clinical risk groups maintained a good immune response and high levels of vaccine effectiveness. However, reduced antibody response and vaccine effectiveness were observed in a broad immunosuppressed group. These results support the prioritization of immunosuppressed individuals for vaccination and the policy of administering third doses.

JOURNAL OF INFECTION (2022)

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Letter Clinical Neurology

A comparative safety study of reported neurological adverse events with three COVID-19 vaccines

Mohit Sodhi et al.

JOURNAL OF NEUROLOGY (2022)

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Article Immunology

COVID-19 vaccine uptake, effectiveness, and waning in 82,959 health care workers: A national prospective cohort study in Wales

Stuart Bedston et al.

Summary: High vaccine uptake was observed among healthcare workers in Wales, with the majority receiving the BNT162b2 vaccine. Age, staff role, and socioeconomic status influenced vaccine uptake. The BNT162b2 vaccine demonstrated strong and consistent effectiveness against SARS-CoV-2 infection, although effectiveness declined over time.

VACCINE (2022)

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Article Clinical Neurology

Neurological Events Reported after COVID-19 Vaccines: An Analysis of Vaccine Adverse Event Reporting System

Jennifer A. Frontera et al.

Summary: This study analyzed data collected from the US Vaccine Adverse Event Reporting System from January 1, 2021 to June 14, 2021. The study found that the rates of neurological events following COVID vaccination were rare, while the rates of neurological complications following acute COVID infection were significantly higher.

ANNALS OF NEUROLOGY (2022)

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Article Infectious Diseases

Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021

Esther Kissling et al.

Summary: According to a multicentre test-negative study, COVID-19 vaccine effectiveness against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. Protection was maintained at 65% at 90 days or more post-vaccination.

EUROSURVEILLANCE (2022)

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Article Medicine, General & Internal

Changes in primary care visits arising from the COVID-19 pandemic: an international comparative study by the International Consortium of Primary Care Big Data Researchers (INTRePID)

Karen Tu et al.

Summary: Through the INTRePID consortium, the impact of the pandemic on primary care visits and virtual care uptake was compared in multiple countries. The study found that there was a global decrease in in-person visits during the pandemic, but virtual visits helped mitigate the drop in several countries.

BMJ OPEN (2022)

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Article Medicine, General & Internal

First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales

Steven Kerr et al.

Summary: This study combined national data from England, Scotland, and Wales to investigate the association between COVID-19 vaccination and CVST. The results showed an elevated risk of CVST following ChAdOx1 vaccination, but not BNT162b2. However, there were limitations in the study due to the rarity of CVST events and potential model assumptions.

PLOS MEDICINE (2022)

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Article Cardiac & Cardiovascular Systems

SARS-CoV-2 Vaccination and Myocarditis in a Nordic Cohort Study of 23 Million Residents

Oystein Karlstad et al.

Summary: Results of this large cohort study indicated that both first and second doses of mRNA vaccines were associated with an increased risk of myocarditis and pericarditis, especially in males aged 16 to 24. These findings are important for vaccine recipients and highlight the need to balance the risks and benefits of COVID-19 vaccination.

JAMA CARDIOLOGY (2022)

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Article Medicine, General & Internal

Risk of myocarditis and pericarditis after the COVID-19 mRNA vaccination in the USA: a cohort study in claims databases

Hui-Lee Wong et al.

LANCET (2022)

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Article Biochemistry & Molecular Biology

Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection

Martina Patone et al.

Summary: Emerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to concerns in regulatory, clinical, and public health sectors. A self-controlled case series study in England showed an increased risk of rare neurological complications following COVID-19 vaccination and infection. The study highlighted a higher risk of Guillain-Barre syndrome after ChAdOx1nCoV-19 vaccination.

NATURE MEDICINE (2021)

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Letter Medicine, General & Internal

Adverse Effects after BNT162b2 Vaccine and SARS-CoV-2 Infection, According to Age and Sex

Noa Dagan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study

Eleftheria Vasileiou et al.

Summary: The study in Scotland found that the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines were associated with substantial reductions in the risk of COVID-19 hospital admission, with vaccine effectiveness ranging from 88% to 91% at 28-34 days post-vaccination.

LANCET (2021)

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Article Infectious Diseases

Benefits and risks associated with different uses of the COVID-19 vaccine Vaxzevria: a modelling study, France, May to September 2021

Cecile Tran Kiem et al.

Summary: The study found that in metropolitan France, the benefits of distributing the Vaxzevria vaccine to individuals aged 55 and older exceeded the risk of death from COVID-19, while in young adults, the risks were at least comparable to the benefits.

EUROSURVEILLANCE (2021)

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Article Biochemistry & Molecular Biology

First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland

C. R. Simpson et al.

Summary: Analysis of data from the EAVE II cohort in Scotland has shown that a first dose of the ChAdOx1 nCoV-19 vaccine may be associated with increased risks of idiopathic thrombocytopenic purpura, arterial thromboembolic events, and hemorrhagic events. However, there were no positive associations found between the BNT162b2 vaccine and these adverse events.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting

Noam Barda et al.

Summary: The study found that after receiving the BNT162b2 vaccine, most adverse events were not associated with an increased risk, although there was a slight increase in the risk of myocarditis. On the other hand, infection with the Covid-19 virus significantly increased the risk of many serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study

Julia Hippisley-Cox et al.

Summary: The study found increased risks of haematological and vascular events leading to hospital admission or death within short time intervals after first doses of the ChAdOx1 nCoV-19 and BNT162b2 mRNA vaccines. The risks of these events were higher and more prolonged after SARS-CoV-2 infection compared to vaccination in the same population.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Health Care Sciences & Services

The Food and Drug Administration Biologics Effectiveness and Safety Initiative Facilitates Detection of Vaccine Administrations From Unstructured Data in Medical Records Through Natural Language Processing

Matthew Deady et al.

Summary: The study showed that using an NLP algorithm to extract vaccine administrations from clinical notes not captured in structured EHR data is feasible and can improve detection efficiency.

FRONTIERS IN DIGITAL HEALTH (2021)

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Article Public, Environmental & Occupational Health

Influenza and Respiratory Virus Surveillance, Vaccine Uptake, and Effectiveness at a Time of Cocirculating COVID-19: Protocol for the English Primary Care Sentinel System for 2020-2021

Simon de Lusignan et al.

Summary: The study aims to monitor influenza and other respiratory conditions using national surveillance data, while also focusing on vaccine uptake and effectiveness. General practices are expected to collect virology and serology specimens and participate in trials and interventional research.

JMIR PUBLIC HEALTH AND SURVEILLANCE (2021)

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Article Biotechnology & Applied Microbiology