4.7 Article

Resveratrol improves diabetic cardiomyopathy by preventing asymmetric dimethylarginine-caused peroxisome proliferator-activated receptor-? coactivator-1? acetylation

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Role of Oxidative Stress in Diabetic Cardiomyopathy

Bart De Geest et al.

Summary: Type 2 diabetes is a redox disease characterized by oxidative stress and chronic inflammation. The cardiac manifestations of the disease, known as diabetic cardiomyopathy, are primarily caused by mitochondrial overproduction of reactive oxygen species. These species are produced due to intracellular hyperglycemia, increased fatty oxidation, and lipotoxicity in cardiomyocytes. The resulting oxidative distress affects various pathways, leading to cell dysfunction and injury. Animal studies have shown that increasing the expression of antioxidant enzymes can attenuate myocardial pathology and improve cardiac function.

ANTIOXIDANTS (2022)

Review Physiology

Novel Insights Into Molecular Mechanism of Mitochondria in Diabetic Cardiomyopathy

Jing Bai et al.

Summary: Diabetic cardiomyopathy is a significant cause of death in diabetic patients, independent of factors like hypertension, with mitochondrial structural and functional impairment playing a key role in disease progression. Therapeutic strategies targeting mitochondria can delay the progression of diabetic cardiomyopathy.

FRONTIERS IN PHYSIOLOGY (2021)

Article Pharmacology & Pharmacy

Endogenous asymmetric dimethylarginine accumulation precipitates the cardiac and mitochondrial dysfunctions in type 1 diabetic rats*

Yan Xiong et al.

Summary: This study showed that endogenous ADMA accumulation contributes to cardiac and mitochondrial dysfunctions in diabetic rats, possibly through NOS uncoupling.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats

Jiayu Diao et al.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2019)

Article Cardiac & Cardiovascular Systems

SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob-/- mice

Damilola D. Adingupu et al.

CARDIOVASCULAR DIABETOLOGY (2019)

Review Cardiac & Cardiovascular Systems

Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity

Guanghong Jia et al.

CIRCULATION RESEARCH (2018)

Article Cardiac & Cardiovascular Systems

Serum concentrations of asymmetric and symmetric dimethylarginine are associated with mortality in acute heart failure patients

Ines Potocnjak et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

The Regulation of Insulin-Stimulated Cardiac Glucose Transport via Protein Acetylation

Edith Renguet et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Multidisciplinary Sciences

Epigenetic control via allosteric regulation of mammalian protein arginine methyltransferases

Kanishk Jain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cardiac & Cardiovascular Systems

Impact of type 2 diabetes and duration of type 2 diabetes on cardiac structure and function

Peter G. Jorgensen et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Article Pharmacology & Pharmacy

Myocardial Energy Substrate Metabolism in Heart Failure: From Pathways to Therapeutic Targets

Arata Fukushima et al.

CURRENT PHARMACEUTICAL DESIGN (2015)

Review Cardiac & Cardiovascular Systems

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I

Francesco Paneni et al.

EUROPEAN HEART JOURNAL (2013)

Article Biochemistry & Molecular Biology

Non-histone lysine acetylated proteins in heart failure

Jean Michel Grillon et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

Article Cardiac & Cardiovascular Systems

The L-Arginine-Asymmetric Dimethylarginine Ratio is an Independent Predictor of Mortality in Dilated Cardiomyopathy

Maike Anderssohn et al.

JOURNAL OF CARDIAC FAILURE (2012)

Article Multidisciplinary Sciences

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne et al.

NATURE (2007)

Article Hematology

Asymmetric dimethylarginine enhances cardiovascular risk prediction in patients with chronic heart failure

Christina Dueckelmann et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1α

Zachary Gerhart-Hines et al.

EMBO JOURNAL (2007)

Article Biochemistry & Molecular Biology

p38 mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis

Yan Xiong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase

Mahesh Thirunavukkarasu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2007)

Review Cardiac & Cardiovascular Systems

Diabetic cardiomyopathy - The search for a unifying hypothesis

IG Poornima et al.

CIRCULATION RESEARCH (2006)

Article Cardiac & Cardiovascular Systems

Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension

F Perticone et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

Article Multidisciplinary Sciences

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

JT Rodgers et al.

NATURE (2005)