Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 183, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2023.106398
Keywords
Peptide; Nebulisation; Anti-inflammatory; Anti-bacterial
Categories
Ask authors/readers for more resources
This study evaluated the suitability of snake-derived peptides (Sn1b, SnE1 and SnE1-F) for nebulisation using a vibrating mesh nebuliser. The peptides showed similar functions after nebulisation and were respirable during simulated mechanical ventilation. The assessment of droplet distributions demonstrated that each peptide would likely be delivered to the lower airways if administered in vivo, suggesting that nebulisation with a vibrating mesh nebuliser is a viable means of delivering these peptides for the treatment of respiratory infections.
Inhalation therapy using nebulisers is an attractive non-invasive route for drug delivery, particularly for the treatment of lung infections with anti-inflammatory and anti-microbial compounds. This study evaluated the suitability of three snake-derived peptides (termed Sn1b, SnE1 and SnE1-F), which we have recently shown have potent anti-inflammatory and bacteriostatic activities, for nebulisation using a vibrating mesh nebuliser (VMN). The effect of nebulisation on peptide concentration, stability and function were assessed, prior to progression to aerodynamic particle size distribution, and in vitro drug delivery in simulated adult spontaneous breathing and mechanical ventilated patient models. When nebulised, all three peptides exhibited similar functions to their non-nebulised counterparts and were found to be respirable during simulated mechanical ventilation. Based on the assessment of the droplet distributions of nebulised peptides using a Next Generation Impactor (NGI) demonstrated that if administered in vivo each peptide would likely be delivered to the lower airways. These data suggest that nebulisation using a VMN is a viable means of anti-microbial / anti-inflammatory peptide delivery targeting microbial respiratory infections, and possibly even systemic infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available