Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2022, Issue 47, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202201218
Keywords
synthetic method; deuteration; ketones; sulfoxides; sulfones; nitriles
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Funding
- Changzhou University
- NSFC/China [22101034, 21901012]
- Changzhou Leading Innovative Talent Project [CQ20210112]
- Jiangsu specially appointed professors program
- Scientific Research Foundation of Jiangsu Provincial Education Department [21KJD150002]
- Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]
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A facile methodology using catalytic BaO for alpha-deuterating ketones, sulfoxides, sulfones and nitriles has been developed. This protocol allows for high deuterium incorporation in a single-run, with broad functional group tolerance, scalability, and applicability in preparing bioactive ketone candidates.
Herein a facile methodology of alpha-deuterating ketones, sulfoxides, sulfones and nitriles using catalytic BaO was developed. The protocol allowed high d-incorporation in a single-run with broad functional group tolerance and was scalable and applicable in preparing exemplary bioactive ketone candidates.
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