Phosphine-Catalyzed [3+2] Cycloaddition of Aza-Aurones and Allenoates: Enantioselective Synthesis of 2-Spirocyclopentyl-Indolin-3-Ones

An enantioselective phosphine-catalyzed [3+2] cycloaddition between aza-aurones and allenoates is here described. The reaction proceeded under mild reaction conditions to afford 2-spirocyclopentyl indolin-3-one derivatives as single gamma-isomer and with high levels of stereocontrol.

Automated summary

This paper describes an enantioselective phosphine-catalyzed [3+2] cycloaddition reaction between aza-aurones and allenoates. The reaction proceeds under mild conditions and offers 2-spirocyclopentyl indolin-3-one derivatives as a single gamma-isomer with high stereocontrol.