Photochemical Cross-Coupling Enables Csp3-C Bond Formation by C-H Homolytic Cleavage: New Developments and Perspectives

Over the past decade with the relaunch of photochemistry, photochemical cross-coupling reactions became an excellent tool for the formation of C-C bond under mild reaction conditions. C(sp(3))-H functionalization of inert substrates, combined with modern transition metal catalysis, provides a powerful tool in organic synthesis. A variety of elegant strategies to initiate a HAT event have been developed, generating alkyl radicals that can be easily intersected with a metal. This review conceptualizes the recent developments in this area, linking them with the seminal contributions that pioneered this research field.

Automated summary

In the past decade, photochemical cross-coupling reactions have emerged as excellent tools for the formation of C-C bonds under mild reaction conditions. By functionalizing inert C(sp(3))-H substrates and utilizing modern transition metal catalysis, alkyl radicals can be easily generated and intersected with metals. This review summarizes the recent developments in this field and connects them with the seminal contributions that pioneered this research area.