Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2022, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202201111
Keywords
1-Aryl-5-pyrazolones; Edaravones; Antipyrines; C-H functionalization
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Funding
- International Research Agendas PLUS programme of the Foundation for Polish Science
- European Union [MAB PLUS/2019/11]
- Knowledge Consortium of Gujarat (KCG), Department of Education, Government of Gujarat, India
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This contribution provides a comprehensive overview of the C-H activation/functionalization reactions of 1-aryl-5-pyrazolones, specifically focusing on edaravones and their N-methyl analogues. It summarizes the recent progress in C-H functionalization reactions of these compounds under transition-metal-catalyzed/free conditions and discusses the related mechanism based on the role of the catalytic species.
In this contribution, we provide a comprehensive overview on the C-H activation/functionalization reactions of 1-aryl-5-pyrazolones, in particular, 1-aryl-3-methyl-1H-pyrazol-5(4H)-ones (edaravones) and their N-methyl analogues i. e., antipyrines covering the literature since 2013 (the year of the first report). This review summarizes the recent progress in C-H functionalization reactions of 1-aryl-5-pyrazolones including edaravone and antipyrine derivatives under transition-metal-catalyzed/free conditions and discusses the related mechanism according to the role of the catalytic species.
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