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CLINICAL NUCLEAR MEDICINE
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Wenhui Fu et al.
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Biochemistry & Molecular Biology
Giorgio Treglia et al.
Summary: Recent studies have compared radiolabeled fibroblast activation protein inhibitors (FAPI) and fluorine-18 fluorodeoxyglucose ([F-18]F-FDG) as PET radiotracers in oncology. The evidence suggests that radiolabeled FAPI PET generally shows equal or higher detection rates for primary tumors and metastatic lesions compared to [F-18]F-FDG PET, particularly in gastrointestinal tumors, liver tumors, breast cancer, and nasopharyngeal carcinoma. Further comparison studies are needed to determine the optimal application of radiolabeled FAPI PET.
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Chunxia Qin et al.
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Yizhen Pang et al.
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Liang Zhao et al.
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EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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Review
Oncology
Serkan Kuyumcu et al.
Summary: FAP, overexpressed on CAFs, is a promising target for molecular imaging of various tumors. Small-molecule FAP inhibitors radiolabeled with Ga-68 have shown potential to compete with (18)FDG in cancer imaging. Theranostic properties of FAP may aid in the treatment of refractory cancers.
FRONTIERS IN ONCOLOGY
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Review
Chemistry, Medicinal
Surachet Imlimthan et al.
Summary: The tumor microenvironment (TME) has become a new paradigm of cancer diagnosis and therapy in the past decade, with cancer-associated fibroblasts (CAFs) being identified as critical stromal cells that regulate tumor growth and progression. Research on FAP-based radiopharmaceuticals for visualizing malignancies and delivering theranostic radiopharmaceuticals to the TME has been intensively investigated. This review provides an overview of TME compositions, particularly CAFs and FAP, and their roles in cancer biology, as well as the challenges and requirements for radiolabeled FAP inhibitors in clinical translation.
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Umut Elboga et al.
Summary: In this study, Ga-68-FAPI PET/CT was found to be superior to (18)FDG PET/CT in detecting more lesions in breast cancer patients. Additionally, Ga-68-FAPI PET/CT was able to lead to a change in treatment approach for patients with newly detected lesions in the post-chemotherapy group.
ANNALS OF NUCLEAR MEDICINE
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Review
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini et al.
Summary: Fibroblast activation protein-alpha (FAP alpha) is a promising target for therapeutic and molecular imaging applications due to its overexpression on cancer-associated fibroblasts in most epithelial neoplasms. [68]Ga-labelled radiopharmaceuticals-FAP-inhibitors (FAPI)-have shown potential in PET imaging for staging, restaging, and radiation treatment planning in various cancers. High heterogeneity was observed in lesion-based analysis, while promising results were seen in patient-based analysis, particularly for primary lesions and distant metastases.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
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Nalan Alan-Selcuk et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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Radiology, Nuclear Medicine & Medical Imaging
Frederik L. Giesel et al.
Summary: The study aimed to compare Ga-68-FAPI and F-18-FDG in organ biodistribution and tumor uptake in PET/CT, showing that Ga-68-FAPI has lower uptake in most normal tissues compared to F-18-FDG, resulting in significantly higher TBRs at some sites for Ga-68-FAPI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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Katharina Dendl et al.
Summary: Ga-68-FAPI-PET/CT demonstrates high tracer uptake for staging and follow-up of gynecological tumors, with sharp contrasts in primary and metastatic lesions and higher TBRs than F-18-FDG-PET/CT. The presence or absence of the menstrual cycle seems to correlate with FAPI accumulation in the normal endometrium and breast.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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Ertan Sahin et al.
Summary: This study compared the diagnostic performance of PET/CT using Ga-68-DOTA-FAPI and (18)FDG in detecting liver metastases in patients with GIS cancers. The results showed that Ga-68-DOTA-FAPI-PET/CT was superior to (18)FDG-PET/CT in detecting liver metastases, with significant differences in lesion-based comparisons and semi-quantitative values.
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Junhao Wu et al.
Summary: This retrospective analysis compared the diagnostic efficacy of [Ga-68]Ga-DOTA-FAPI-04 and [F-18]FDG PET/CT in detecting bone metastases in cancer patients. Results showed that [Ga-68]Ga-DOTA-FAPI-04 PET/CT was more sensitive in diagnosing bone metastases compared to [F-18]FDG PET/CT, with higher tracer uptake levels, but also presented a higher rate of false-positive lesions.
FRONTIERS IN ONCOLOGY
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