Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 244, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2022.114814
Keywords
Fusidic acid; STING inhibitor; Anti-inflammatory; Sepsis
Categories
Funding
- National Natural Science Foundation of China [81773563, 81973547]
- Science and Technology Support Program for Youth Innovation in Universities of Shandong [2020KJM003]
- College Students Innovation and Entrepreneurship Training Program [202211066013]
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In this study, a new series of fusidic acid derivatives were designed and synthesized, and compound 30 was identified as a potent STING inhibitor with the ability to suppress LPS-induced inflammatory responses. In vivo experiments confirmed the anti-inflammatory effect of compound 30 and its potential for treating sepsis. This study lays the groundwork for the future development of anti-inflammatory agents for sepsis treatment.
Sepsis promising treatment target for sepsis. In this study, we report the design and synthesis of a new series of fusidic acid derivatives. Among the synthesized derivatives, the promising compound 30 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in macrophages with an IC50 of 1.15 mu M. Compound 30 was then identified as a STING inhibitor that suppressed LPS-induced inflammatory responses and inhibited the abnormal activation of the TBK1, IRF3, and NF-kappa B signaling pathways by targeting STING. In vivo treatment with compound 30 significantly inhibited the inflammatory response and ameliorated the histopathological changes of the liver, and the mechanism of its anti-inflammatory effect in vivo was the same as that in vitro. Our studies identified compound 30 as a potent STING inhibitor, laying the groundwork for future drug development of anti-inflammatory agents for the treatment of sepsis.
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