Related references
Note: Only part of the references are listed.An overview of cdc2-like kinase 1 (Clk1) inhibitors and their therapeutic indications
Ahmed K. ElHady et al.
MEDICINAL RESEARCH REVIEWS (2023)
Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
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RETROVIROLOGY (2022)
5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency
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MOLECULES (2021)
The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
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CANCER LETTERS (2020)
New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis
Helmi Tazarki et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Regulation of influenza A virus mRNA splicing by CLK1
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ANTIVIRAL RESEARCH (2019)
SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Tumor Protein p53 (TP53)-Mutant Acute Myeloid Leukemia Models
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BLOOD (2019)
Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway
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ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation
Akinori Yoda et al.
BLOOD (2019)
Recent Developments in the Reduction of Aromatic and Aliphatic Nitro Compounds to Amines
Manuel Orlandi et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2018)
Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells
Elizabeth Bowler et al.
BMC CANCER (2018)
Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives
Sarah S. Darwish et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Autoregulation of the human splice factor kinase CLK1 through exon skipping and intron retention
Simon Uzor et al.
GENE (2018)
Development of novel amide-derivatized 2,4-bispyridyl thiophenes as highly potent and selective Dyrk1A inhibitors. Part II: Identification of the cyclopropylamide moiety as a key modification
Sarah S. Darwish et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers
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JOURNAL OF MEDICINAL CHEMISTRY (2017)
Development of Selective Clk1 and-4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins
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JOURNAL OF MEDICINAL CHEMISTRY (2017)
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
Tyler Funnell et al.
NATURE COMMUNICATIONS (2017)
Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy
Yukiya Sako et al.
SCIENTIFIC REPORTS (2017)
Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2
Marica Mariano et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain
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JOURNAL OF MEDICINAL CHEMISTRY (2016)
Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy
Maayan Salton et al.
TRENDS IN MOLECULAR MEDICINE (2016)
A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs
Alexander Karlas et al.
NATURE COMMUNICATIONS (2016)
Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
Eleni Petsalaki et al.
NATURE COMMUNICATIONS (2016)
BTeam, a Novel BRET-based Biosensor for the Accurate Quantification of ATP Concentration within Living Cells
Tomoki Yoshida et al.
SCIENTIFIC REPORTS (2016)
Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia
Egle Jakubauskiene et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment
Mian Zu et al.
MOLECULES (2015)
Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing
Shinsuke Araki et al.
PLOS ONE (2015)
Human CDC2-Like Kinase 1 (CLK1): A Novel Target for Alzheimer's Disease
Princi Jain et al.
CURRENT DRUG TARGETS (2014)
Metabolic stability optimization and metabolite identification of 2,5-thiophene amide 17β-hydroxysteroid dehydrogenase type 2 inhibitors
Emanuele M. Gargano et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors
Christian Schmitt et al.
PLOS ONE (2014)
Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4
Christian Schmitt et al.
ACS MEDICINAL CHEMISTRY LETTERS (2014)
Phosphorylation of the alternative mRNA splicing factor 45 (SPF45) by Clk1 regulates its splice site utilization, cell migration and invasion
Yuying Liu et al.
NUCLEIC ACIDS RESEARCH (2013)
Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells
Andreas Eisenreichi et al.
ONCOLOGY REPORTS (2013)
Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B
Tania Tahtouh et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor
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JOURNAL OF CELL BIOLOGY (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
Theonie Anastassiadis et al.
NATURE BIOTECHNOLOGY (2011)
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
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RETROVIROLOGY (2011)
Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors
Gregory D. Cuny et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Cdc2-like Kinase 2 Is an Insulin-Regulated Suppressor of Hepatic Gluconeogenesis
Joseph T. Rodgers et al.
CELL METABOLISM (2010)
Synthesis and Antifungal Activities of New Pyrazole Derivatives via 1,3-dipolar Cycloaddition Reaction
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CHEMICAL BIOLOGY & DRUG DESIGN (2010)
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
Alexander Karlas et al.
NATURE (2010)
Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation
Alex N. Bullock et al.
STRUCTURE (2009)
Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A
Jun-ichiro Yomoda et al.
GENES TO CELLS (2008)
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)