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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat
Nadia L. Caram-Salas et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Long-acting κ opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase
Michael R. Bruchas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at μ, δ, and κ opioid receptors
Xuemei Peng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone
D. T. Beattie et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2007)
Oxycodone:: a pharmacological and clinical review
A. Ordonez Gallego et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2007)
Dynorphin A activates bradykinin receptors to maintain neuropathic pain
Josephine Lai et al.
NATURE NEUROSCIENCE (2006)
Dynorphin A, kappa opioid receptors and the antinociceptive efficacy of asimadoline in streptozotocin-induced diabetic rats
C. G. Jolivalt et al.
DIABETOLOGIA (2006)
Synthesis and in vitro evaluation of salvinorin A analogues:: Effect of configuration at C(2) and substitution at C(18)
Cecile Beguin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Anti-inflammatory effects of contralateral administration of the κ-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis
I Bileviciute-Ljungar et al.
RHEUMATOLOGY (2006)
Psychopharmacology of the hallucinogenic sage Salvia divinorum
TE Prisinzano
LIFE SCIENCES (2005)
Effects of JDTic, a selective κ-opioid receptor antagonist, on the development and expression of physical dependence on morphine using a rat continuous-infusion model
FI Carroll et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats
PM Beardsley et al.
PSYCHOPHARMACOLOGY (2005)
Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands
WW Harding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
[Nα-BenzylTyr1,cyclo(D-Asp5,Dap8)]dynorphin A-(1-11)NH2 cyclized in the address domain is a novel K-opioid receptor antagonist
KA Patkar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers
M Waldhoer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2)
C Béguin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
A bivalent ligand (KDAN-18) containing δ-antagonist and k-agonist pharmacophores bridges δ2 and k1 opioid receptor phenotypes
DJ Daniels et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men
NK Mello et al.
NEUROPSYCHOPHARMACOLOGY (2005)
Kappa opioid antagonists: Past successes and future prospects
MD Metcalf et al.
AAPS JOURNAL (2005)
Peripheral kappa-opioid agonists for visceral pain
PJM Rivière
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Effects of the mixed-action κ/μ opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys
GW Stevenson et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
FE200041 (D-Phe-D-Phe-D-Nle-D-Arg-NH2):: A peripheral efficacious κ opioid agonist with unprecedented selectivity
TW Vanderah et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Contralateral, ipsilateral and bilateral treatments with the K-opioid receptor agonist U-50,488H in mononeuropathic rats
I Bileviciute-Ljungar et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Synthesis and evaluation of the affinity toward μ-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-]
G Cardillo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Pharmacological properties of JDTic:: a novel κ-opioid receptor antagonist
I Carroll et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Identification of (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide as a novel potent and selective opioid κ receptor antagonist
JB Thomas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Effects of mixed-action κ/μ opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys
CA Bowen et al.
NEUROPSYCHOPHARMACOLOGY (2003)
Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis
JC Eisenach et al.
PAIN (2003)
CJ-15,208, a novel kappa opioid receptor antagonist from a fungus, Ctenomyces serratus ATCC15502
T Saito et al.
JOURNAL OF ANTIBIOTICS (2002)
Kappa opioid antagonist effects of the novel kappa antagonist 5′-guanidinonaltrindole (GNTI) in an assay of schedule-controlled behavior in rhesus monkeys
SS Negus et al.
PSYCHOPHARMACOLOGY (2002)
Salvinorin A:: A potent naturally occurring nonnitrogenous κ opioid selective agonist
BL Roth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
8-carboxamidocyclazocine: A long-acting, novel benzomorphan
JM Bidlack et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Diazabicyclononanones, a potent class of kappa opioid analgesics
U Holzgrabe et al.
FARMACO (2002)
Effects of a newly synthesized κ-opioid receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats
T Mori et al.
PSYCHOPHARMACOLOGY (2002)
Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats
A Sandner-Kiesling et al.
PAIN (2002)
Effects of subcutaneous methylnaltrexone on morphine-induced peripherally mediated side effects: A double-blind randomized placebo-controlled trial
CS Yuan et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Identification of the first trans-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid κ receptor antagonist activity
JB Thomas et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole
SK Sharma et al.
JOURNAL OF MEDICINAL CHEMISTRY (2001)
Analgesic and antiinflammatory effects of two novel κ-opioid peptides
W Binder et al.
ANESTHESIOLOGY (2001)
8-carboxamidocyclazocine analogues: Redefining the structure-activity relationships of 2,6-methano-3-benzazocines
MP Wentland et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
5′-guanidinonaltrindole, a highly selective and potent κ-opioid receptor antagonist
RM Jones et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2000)
Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives:: Mixed κ agonists and μ agonists/antagonists as potential pharmacotherapeutics for cocaine dependence
JL Neumeyer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)