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Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

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Summary: The study provides detailed analysis on the gene-drug interaction between the genes CYP2C19 and CYP2D6 and selective serotonin reuptake inhibitor (SSRIs) antidepressants, offering specific dosage adjustment recommendations for patients with different genotypes. The results suggest that genotyping before starting specific antidepressants can be beneficial for toxicity/effectivity predictions.

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Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)

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