4.7 Editorial Material

The year in cardiovascular medicine 2022: the top 10 papers in heart failure and cardiomyopathies

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial

Joan Carles Trullas et al.

Summary: This study aims to evaluate whether adding hydrochlorothiazide (HCTZ) to intravenous furosemide is a safe and effective strategy for improving diuretic response in acute heart failure (AHF). The study found that adding HCTZ to loop diuretic therapy can improve diuretic response in patients with AHF, but may also lead to renal function impairment.

EUROPEAN HEART JOURNAL (2023)

Article Cardiac & Cardiovascular Systems

Accelerated and personalized therapy for heart failure with reduced ejection fraction

Li Shen et al.

Summary: Previous guidelines for treating heart failure with reduced ejection fraction recommended initiating therapy in a chronological order based on trial history. However, this study suggests that accelerating treatment titration and optimizing treatment ordering may improve patient outcomes.

EUROPEAN HEART JOURNAL (2022)

Article Medicine, General & Internal

Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial

Justin A. Ezekowitz et al.

Summary: Restricting dietary sodium intake does not reduce the occurrence of clinical events in patients with heart failure.

LANCET (2022)

Article Biochemistry & Molecular Biology

The SGLT2 inhibitor empagliflozin in patients hospitalized for acute heart failure: a multinational randomized trial

Adriaan A. Voors et al.

Summary: The sodium-glucose cotransporter 2 inhibitor empagliflozin improves clinical outcomes in patients hospitalized for acute heart failure, regardless of ejection fraction or the presence of diabetes.

NATURE MEDICINE (2022)

Article Medicine, General & Internal

Safety, tolerability, and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial

Alexandre Mebazaa et al.

Summary: This study aimed to investigate the impact of guideline-directed medical therapy dose and up-titration pace on the efficacy and safety of patients admitted to the hospital for acute heart failure. The results showed that compared with usual care, high-intensity care significantly reduced the risk of heart failure readmission or all-cause death within 180 days.

LANCET (2022)

Article Cardiac & Cardiovascular Systems

Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial

Javed Butler et al.

Summary: The study found that patiromer can significantly lower serum potassium levels and enable specified target doses of RAASi in patients with heart failure and reduced ejection fraction, reducing the risk of hyperkalemia.

EUROPEAN HEART JOURNAL (2022)

Article Medicine, General & Internal

Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction

Divaka Perera et al.

Summary: In patients with severe ischemic left ventricular systolic dysfunction, revascularization by PCI did not result in a lower incidence of death or hospitalization for heart failure compared to optimal medical therapy.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Medicine, General & Internal

Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

S. D. Solomon et al.

Summary: The study shows that SGLT2 inhibitors are effective in reducing the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or less. However, whether they are effective in patients with a higher left ventricular ejection fraction remains uncertain.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Medicine, General & Internal

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload

Wilfried Mullens et al.

Summary: The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure results in a higher incidence of successful decongestion without increasing adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2022)