Parosmia as a predictor of a better olfactory function in COVID-19: a multicentric longitudinal study for upper respiratory tract infections

Article Biochemistry & Molecular Biology

Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia

Marianna Zazhytska et al.

Summary: SARS-CoV-2 infection causes downregulation of olfactory receptors and their signaling components, offering insights into its effects on olfaction and other systems.

CELL (2022)

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Article Medicine, Research & Experimental

Clinical Features of Parosmia Associated With COVID-19 Infection

David K. Lerner et al.

Summary: COVID-19-related olfactory dysfunction is often associated with the development of parosmia, which can occur either at the onset of smell loss or after a delay. Despite better quantitative olfactory scores, respondents with parosmia report decreased quality of life. The majority of respondents with persistent parosmia have sought treatment.

LARYNGOSCOPE (2022)

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Article Otorhinolaryngology

Prevalence of Persistent Olfactory Disorders in Patients With COVID-19: A Psychophysical Case-Control Study With 1-Year Follow-up

Luigi Angelo Vaira et al.

Summary: This study evaluated olfactory dysfunction in patients after COVID-19 and found that the prevalence of OD was significantly higher in the COVID-19 group compared to the control group, indicating that this result was not affected by the baseline prevalence of OD in the general population.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2022)

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Article Otorhinolaryngology

Coronavirus disease 2019 (COVID-19)-related smell and taste impairment with widespread diffusion of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) Omicron variant

Paolo Boscolo-Rizzo et al.

Summary: The prevalence and severity of COVID-19-associated smell and taste dysfunction has significantly decreased with the advent of the Omicron variant but it still remains above 30%.

INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY (2022)

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Article Biology

SARS-CoV-2 Leads to Significantly More Severe Olfactory Loss than Other Seasonal Cold Viruses

Antje Haehner et al.

Summary: The aim of this study was to compare COVID-associated olfactory impairment with olfactory disorders caused by other upper respiratory tract infections. The study found that SARS-CoV-2 leads to a more severe loss of smell and more qualitative olfactory disorders compared to other pathogens. Olfactory screening significantly improves diagnostic accuracy in COVID-19 patients.

LIFE-BASEL (2022)

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Article

“Olfactory dysfunction and COVID-19”

Rhea Choi et al.

Operative Techniques in Otolaryngology - Head and Neck Surgery (2022)

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Review Otorhinolaryngology

The Prevalence of Olfactory Dysfunction in the General Population: A Systematic Review and Meta-analysis

Vincent M. Desiato et al.

Summary: Olfactory dysfunction (OD) is common and has been reported as an early indicator of COVID-19. The prevalence of OD in the general population depends on the testing method and population age, with greater prevalence in studies using objective tests and older subjects.

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY (2021)

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Review Cell Biology

Human olfactory dysfunction: causes and consequences

Laura Schaefer et al.

Summary: The sense of smell is crucial for social communication, nutrition behavior, and avoiding environmental hazards. Olfactory impairment can have severe consequences, often going unnoticed and diagnosed late. Discussing individual characteristics associated with serious mental health impairment can help practitioners identify high-risk populations.

CELL AND TISSUE RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Article Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

Mona Khan et al.

Summary: Anosmia, the loss of smell, is a common symptom of COVID-19, but it is caused by the virus attacking sustentacular cells in the olfactory mucosa rather than infecting olfactory sensory neurons. This suggests that SARS-CoV-2 is not a neurotropic virus.

CELL (2021)

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Article Medicine, General & Internal

Prevalence and 6-month recovery of olfactory dysfunction: a multicentre study of 1363 COVID-19 patients

J. R. Lechien et al.

Summary: This study found that olfactory dysfunction (OD) is more prevalent in mild cases of COVID-19 compared to moderate-to-critical forms. Additionally, 24.1% of patients did not subjectively recover olfaction 60 days after the onset of the dysfunction. Objective olfactory evaluations identified hyposmia/anosmia in a significant percentage of patients, with higher baseline severity of objective olfactory evaluations strongly predictive of persistent OD.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Medicine, Research & Experimental

Parosmia is Associated with Relevant Olfactory Recovery After Olfactory Training

David T. Liu et al.

Summary: The study found that the presence of parosmia is associated with clinically relevant recovery in olfactory discrimination and identification function in patients with PIOD receiving olfactory training, with patients who have lower baseline olfactory function being more likely to show significant improvements.

LARYNGOSCOPE (2021)

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Article Medicine, Research & Experimental

Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients

Jeyasakthy Saniasiaya et al.

Summary: A systematic review and meta-analysis found that the overall prevalence of olfactory dysfunction in COVID-19 patients is 47.85%, with European patients having the highest prevalence and Asian patients the lowest. Discrepancies between objective and subjective evaluations suggest further studies are needed.

LARYNGOSCOPE (2021)

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Article Behavioral Sciences

Six-Month Psychophysical Evaluation of Olfactory Dysfunction in Patients with COVID-19

Paolo Boscolo-Rizzo et al.

Summary: This study found that as the time since virus infection increases, olfactory dysfunction becomes more common among patients, with a high percentage showing persistent dysfunction despite most patients subjectively reporting normal smell.

CHEMICAL SENSES (2021)

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Article Otorhinolaryngology

Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers

Juan Riestra-Ayora et al.

Summary: In COVID-19 patients, olfactory and gustatory dysfunction showed high-resolution rates within the first two months after onset, but 11% did not fully recover and 30% partially recovered after 6 months. There was a high correlation between olfactory and gustatory dysfunction, while nasal obstruction and dyspnea were identified as risk factors for symptom persistence.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2021)

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Article Cell Biology

COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters

Guilherme Dias de Melo et al.

Summary: Recent investigations have shown that olfactory and taste dysfunction are common in mildly symptomatic COVID-19 patients. Research on the olfactory neuroepithelium revealed that SARS-CoV-2 infection can cause local inflammation and lead to acute loss of smell, which may account for prolonged symptoms of COVID-19 such as anosmia.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Otorhinolaryngology

Association of Olfactory Training With Neural Connectivity in Adults With Postviral Olfactory Dysfunction

Pawina Jiramongkolchai et al.

Summary: The baseline functional connectivity in adults with postviral olfactory dysfunction (PVOD) shows increased connections within the visual cortex, which decrease after 3 months of olfactory training (OT) and are replaced by increased connectivity between brain regions involved in olfaction. This suggests a bimodal interaction between the visual and olfactory cortex during OT, highlighting the need for further studies on the efficacy of a bimodal visual and OT program for adults with PVOD.

JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY (2021)

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Article Behavioral Sciences

Six-Month Psychophysical Evaluation of Olfactory Dysfunction in Patients with COVID-19

Paolo Boscolo-Rizzo et al.

Summary: This study prospectively assessed the 6-month prevalence of olfactory dysfunction in subjects with mild-to-moderate COVID-19. Despite most patients reporting a subjectively normal sense of smell, a high percentage of persistent smell dysfunction was observed at 6 months, highlighting a significant long-term rate of smell alteration in patients with previous SARS-CoV-2 infection.

CHEMICAL SENSES (2021)

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Article Neurosciences

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

Michael A. Durante et al.

NATURE NEUROSCIENCE (2020)

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Letter Immunology

Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study

Andrea Giacomelli et al.

CLINICAL INFECTIOUS DISEASES (2020)

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Article Otorhinolaryngology

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Jerome R. Lechien et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2020)

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Article Multidisciplinary Sciences

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

David H. Brann et al.

SCIENCE ADVANCES (2020)

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Review Geriatrics & Gerontology

Age-Related Olfactory Dysfunction: Epidemiology, Pathophysiology, and Clinical Management

Kenji Kondo et al.

FRONTIERS IN AGING NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Assessment of odor hedonic perception: the Sniffin' sticks parosmia test (SSParoT)

David T. Liu et al.

SCIENTIFIC REPORTS (2020)

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Letter Otorhinolaryngology

Comparison of COVID-19 and common cold chemosensory dysfunction

C. Huart et al.

RHINOLOGY (2020)

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Article Otorhinolaryngology

Updated Sniffin' Sticks normative data based on an extended sample of 9139 subjects

A. Oleszkiewicz et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2019)

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Review Psychology, Multidisciplinary

Sex Differences in Human Olfaction: A Meta-Analysis

Piotr Sorokowski et al.

FRONTIERS IN PSYCHOLOGY (2019)

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Article Medicine, Research & Experimental

Postinfectious olfactory loss: A retrospective study on 791 patients

Annachiara Cavazzana et al.

LARYNGOSCOPE (2018)

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Article Neuroimaging

Changes in olfactory bulb volume following lateralized olfactory training

S. Negoias et al.

BRAIN IMAGING AND BEHAVIOR (2017)

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Article Geriatrics & Gerontology

The Rate of Age-Related Olfactory Decline Among the General Population of Older US Adults

Jayant M. Pinto et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)

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Article Behavioral Sciences

Olfactory Disorders and Quality of Life-An Updated Review

Ilona Croy et al.

CHEMICAL SENSES (2014)

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Article Otorhinolaryngology

Hidden consequences of olfactory dysfunction: a patient report series

Andreas Keller et al.

BMC EAR NOSE AND THROAT DISORDERS (2013)

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Article Otorhinolaryngology

Prognostic Value of Olfactory Bulb Volume Measurement for Recovery in Postinfectious and Posttraumatic Olfactory Loss

Philippe Rombaux et al.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY (2012)

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Article Otorhinolaryngology

Prognostic Factors of Olfactory Dysfunction

Thomas Hummel et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2010)

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Article Clinical Neurology

Taste Strips - A rapid, lateralized, gustatory bedside identification test based on impregnated filter papers

Basile Nicolas Landis et al.

JOURNAL OF NEUROLOGY (2009)

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Article Medicine, Research & Experimental

Effects of Olfactory Training in Patients with Olfactory Loss

Thomas Hummel et al.

LARYNGOSCOPE (2009)

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Article Otorhinolaryngology

Correlation of olfactory function with changes in the volume of the human olfactory bulb

Antje Haehner et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2008)

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Article Otorhinolaryngology

Normative data for the Sniffin' Sticks including tests of odor identification, odor discrimination, and olfactory thresholds: an upgrade based on a group of more than 3,000 subjects

T. Hummel et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2007)

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Article Otorhinolaryngology

A study on the prognostic significance of qualitative olfactory dysfunction

J. Reden et al.

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY (2007)

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Article Otorhinolaryngology

Recovery of olfactory function following closed head injury or infections of the upper respiratory tract

J Reden et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2006)

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Article Otorhinolaryngology

Olfactory dysfunction -: epidemiological data and treatment strategies in Germany, Austria, and Switzerland

M Damm et al.

HNO (2004)

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Article Medicine, General & Internal

Prevalence of olfactory impairment in older adults

C Murphy et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)

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Article Behavioral Sciences

Distortion of olfactory perception: Diagnosis and treatment

D Leopold

CHEMICAL SENSES (2002)

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Clinical assessment of retronasal olfactory function

S Heilmann et al.

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY (2002)

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Article Geriatrics & Gerontology

Odor identification: Influences of age, gender, cognition, and personality

M Larsson et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2000)

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Parosmia as a predictor of a better olfactory function in COVID-19: a multicentric longitudinal study for upper respiratory tract infections

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