Isoliquiritigenin induces oxidative stress and immune response in zebrafish embryos

Isoliquiritigenin (ISL) is used in many households' personal hygiene and medicinal products, and the average human daily ISL exposure is 1-2 mg/kg. However, the molecular mechanisms of ISL toxicity in zebrafish embryos have not been fully elucidated. We investigated whether exposure to ISL induces oxidative stress and inflammatory responses in zebrafish. And exposure to ISL significantly affects the expression of immune response-related genes in zebrafish embryos following oxidative stress and the release of pro-inflammatory mediators through Toll-like receptor signaling.

Automated summary

This study investigated the potential oxidative stress and inflammatory responses induced by isoliquiritigenin (ISL) in zebrafish embryos. It was found that ISL exposure significantly affected the expression of immune response-related genes and the release of pro-inflammatory mediators.