Bisphenol A alters sexual dimorphism and gene expression in marine medaka Oryzias melastigma

Bisphenol A (BPA) is an endocrine disruptor that is present in freshwater and marine environments. However, conclusive evidence for the toxicity of chronic BPA exposure to marine fishes remains lacking. Therefore, we investigated the influence of BPA on male marine medaka (Oryzias melastigma). BPA exposure induced formation of testis-ova at 2610 mu g/L, and male-type anal fins became more female type in a concentration-dependent manner. Some males with female-type anal fins had normal testes, indicating that anal fin shape is more sensitive to BPA. Gonadal soma-derived factor (gsdf) expression decreased after BPA exposure in the 746 and 2610 mu g/L exposure groups, although the changes were not statistically significant. Additionally, liver vitellogenin (vtg) expression increased in a dose-dependent manner and was significantly higher in all exposure groups. vtg and gsdf are likely to be useful biomarkers for the impact of estrogenic endocrine disrupters in O. melastigma.

Automated summary

Bisphenol A (BPA), an endocrine disruptor found in freshwater and marine environments, has been shown to induce feminization in male marine medaka fish. The expression of gonadal soma-derived factor (gsdf) decreased, while liver vitellogenin (vtg) expression increased, indicating the potential use of vtg and gsdf as biomarkers for evaluating the impact of estrogenic endocrine disruptors in O. melastigma.