Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.est.2c03181
Keywords
PFASs; dermal absorption; skin retention; toxicokinetics; perfluorinated carbon chain length
Categories
Funding
- Natural Science Foundation of China (NSFC) [41991313, 21737003, 22111530176, 42161134001]
- Ministry of Science and Technology [2019YFC1804203, 2018YFC1801003]
- Fundamental Research Funds for the Central Universities, Nankai University
- 111 program of Ministry of Education, China [T2017002]
- Chinese University Scientific Fund [2452021103]
Ask authors/readers for more resources
This study used a rat model to estimate the dermal penetration efficiency of 15 representative PFASs. The results showed that the penetration and absorption of PFASs were parabolically associated with the perfluorinated carbon chain length. The lipid-rich stratum corneum of the skin barrier suppressed the penetration of less hydrophobic short-chain PFASs, while the water-rich viable epidermis and dermis served as obstacles to hydrophobic long-chain PFAS permeation. Short-chain PFASs were mainly eliminated through urinary excretion, while long-chain PFASs entered the body through dermal penetration. These results highlight the significant contribution of dermal penetration to the body burden of PFASs.
Humans are frequently exposed to poly-and perfluoroalkyl substances (PFASs) via direct skin contact with personal care and consumer products containing them. Here, we used a rat model to estimate the dermal penetration efficiency of 15 representative PFASs. After 144 h post-dosing, 4.1- 18.0 and 5.3-15.1% of the applied PFASs in the low (L) and high (H) groups, respectively, were absorbed into the rats. PFAS absorption and permeation were parabolically associated with the perfluorinated carbon chain length (CF), peaking for perfluoroheptanoic acid (PFHpA). The lipid-rich stratum corneum of the skin barrier substantially suppressed the penetration of less hydrophobic short-chain PFASs, whereas the water-rich viable epidermis and dermis served as obstacles to hydrophobic long-chain PFAS permeation. However, the renal clearance (CLrenal) of the target PFAS decreased with increasing CF, suggesting that urinary excretion is crucial to eliminate less hydrophobic short-chain PFASs. Notably, the peak times of PFASs in the systemic circulation of rats (8-72 h) were remarkably longer than those after oral administration (1-24 h). These results suggest that dermal penetration can be long-lasting and contribute considerably to the body burden of PFASs, especially for those with moderate hydrophobicity due to their favorable skin permeation and unfavorable urinary excretion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available