Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 34, Issue -, Pages 1-7Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2015.11.002
Keywords
Inflammation; Macrophages; T lymphocytes; Oxysterols; Fatty acids
Funding
- NHLBI NIH HHS [K01 HL121010] Funding Source: Medline
- NIDDK NIH HHS [F30 DK103438] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007347] Funding Source: Medline
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Immune cell plasticity has extensive implications in the pathogenesis and resolution of metabolic disorders, cancers, autoimmune diseases and chronic inflammatory disorders. Over the past decade, nutritional status has been discovered to influence the immune response. In metabolic disorders such as obesity, immune cells interact with various classes of lipids, which are capable of controlling the plasticity of macrophages and T lymphocytes. The purpose of this review is to discuss lipids and their impact on innate and adaptive immune responses, focusing on two areas: (1) the impact of altering lipid metabolism on immune cell activation, differentiation and function and (2) the mechanism by which lipids such as cholesterol and fatty acids regulate immune cell plasticity. (C) 2015 Elsevier Inc. All rights reserved.
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