Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 32, Issue -, Pages 123-127Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2016.02.007
Keywords
Branched-chain amino acids; Cardiometabolic risk; Body mass index
Funding
- Zukunftsfond Steiermark Project STYJOBS
- Zukunftsfond Steiermark Project STYJOBS-Extension
Ask authors/readers for more resources
Cardiovascular risk is increased in obese subjects. Nevertheless, some overweight and obese remain cardiometabolically healthy (CMH), and normal-weight persons develop cardiovascular disease (CVD). Herein, we investigate the potential of branched-chain amino acids (BCAAs) to identify an increased CVD risk in a cross-sectional study of 666 adults and juveniles (age 25.3 +/- 12.8 years), classified as lean, overweight or obese. Cardiometabolic groups were defined by cutoffs of systolic blood pressure <130 mmHg, diastolic blood pressure<85 mmHg, glucose <125 mg/dl, triglycerides <150 mg/dl, HDL-cholesterol>40 mg/dl (males), HDL-cholesterol>50 mg/dl (females) and HOMA-IR<5. CMH had <= 1 cutoff, and cardiometabolically abnormal (CMA) had >= 2 cutoffs. Amino acids were measured by high-pressure lipid chromatography after precipitation of serum with perchloric acid and derivatization with o-phthalaldehyde. Valine correlated with 5, leucine correlated with 3 and isoleucine correlated with 5 of the cardiac risk classification factors. Valine and leucine were significantly higher in the obese (P<.001, P=.015, respectively), overweight (P<.001, P=.015, respectively) and lean (P=.024, P=.012, respectively) CMA compared to CMH subjects. Isoleucine showed except of the lean group the same results. Taken together, BCAAs, especially valine and leucine, are proposed as a cardiometabolic risk marker independent of body mass index (BMI) category. (C) 2016 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available