4.7 Article

p38 MAPK-dependent phosphorylation of TFEB promotes monocyte-to-macrophage differentiation

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

A conserved cysteine-based redox mechanism sustains TFEB/HLH-30 activity under persistent stress

Jose A. Martina et al.

Summary: Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH-30, are regulated by a novel mechanism involving cysteine-mediated redox switch under stress conditions, leading to oligomer formation and increased stability to stress. Cysteine oxidation acts as a molecular switch linking redox balance changes with expression of target genes.

EMBO JOURNAL (2021)

Review Cell Biology

Diversity and versatility of p38 kinase signalling in health and disease

Begona Canovas et al.

Summary: The ability of cells to cope with various stressful situations is crucial for survival, with p38 alpha kinase playing a key role in the cellular stress response. Understanding the diversity of p38 alpha substrates, their mechanisms, and their connections to specific cellular functions is important for insights into physiology and pathology. Dysregulation of the p38 alpha pathway has been linked to diseases such as inflammation, immune disorders, and cancer.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

Mathieu Paquette et al.

Summary: It has been shown that AMPK regulates the transcriptional activity of TFEB and TFE3 through phosphorylation, with a significant impact during nutrient deprivation, FLCN depletion, and pharmacological manipulation of MTORC1 or AMPK. MTORC1 specifically controls the cytosolic retention of TFEB and TFE3, while AMPK is essential for their transcriptional activity. This dual and opposing regulation mechanism is reminiscent of the regulation of ULK1, another key regulator of autophagy.

AUTOPHAGY (2021)

Review Cell Biology

TFEB - at the crossroads of host-pathogen interactions

Keerti et al.

Summary: The dynamic interactions between host and pathogen play a crucial role in determining their fate, with the transcription factor TFEB being key in autophagy-lysosomal function. Infection with certain pathogens can cause TFEB translocation and activation of pathways targeting intracellular pathogens. Understanding the complex functions of TFEB in host-pathogen interactions may provide insights into its potential as a therapeutic target.

JOURNAL OF CELL SCIENCE (2021)

Review Biochemistry & Molecular Biology

MiT Family Transcriptional Factors in Immune Cell Functions

Seongryong Kim et al.

Summary: The MiT family proteins are evolutionarily conserved transcription factors that play essential roles in regulating cellular functions. They are best known for their involvement in lysosome biogenesis and autophagy induction, while also having effects on cellular metabolism, mitochondrial dynamics, and stress responses. Each MiT family member plays distinct or redundant roles in different immune cell types, and there is still much to learn about their functions and regulatory mechanisms in host defense and inflammatory responses.

MOLECULES AND CELLS (2021)

Article Oncology

TFEB Links MYC Signaling to Epigenetic Control of Myeloid Differentiation and Acute Myeloid Leukemia

Seongseok Yun et al.

Summary: MYC oncoproteins regulate cell proliferation, metabolism, and tumorigenesis in AML by suppressing TFEB; TFEB acts as a tumor suppressor and induces differentiation through IDH1/IDH2 in AML; the TFEB-IDH1/IDH2-TET2 axis is a targetable vulnerability in AML.

BLOOD CANCER DISCOVERY (2021)

Article Biochemistry & Molecular Biology

Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB

Yusha Wang et al.

EMBO REPORTS (2020)

Review Immunology

Caspases in Cell Death, Inflammation, and Pyroptosis

Sannula Kesavardhana et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Review Immunology

Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation

Javier E. Irazoqui

TRENDS IN IMMUNOLOGY (2020)

Article Oncology

TFEB is a master regulator of tumor-associated macrophages in breast cancer

Yong Li et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Cell Biology

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

Qiuyuan Yin et al.

JOURNAL OF CELL BIOLOGY (2020)

Article Immunology

Priming Is Dispensable for NLRP3 Inflammasome Activation in Human MonocytesIn Vitro

Anna Gritsenko et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Cell Biology

MITF-the first 25 years

Colin R. Goding et al.

GENES & DEVELOPMENT (2019)

Review Biochemistry & Molecular Biology

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

Nathan Kelley et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Cell Biology

Emerging roles and regulation of MiT/TFE transcriptional factors

Min Yang et al.

CELL COMMUNICATION AND SIGNALING (2018)

Review Biochemistry & Molecular Biology

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Rosa Puertollano et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

Jose A. Martina et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Cynthia L. Hsu et al.

NATURE COMMUNICATIONS (2018)

Review Cell Biology

Emerging roles for TFEB in the immune response and inflammation

Owen A. Brady et al.

AUTOPHAGY (2018)

Article Multidisciplinary Sciences

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Ismail Sergin et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

STUB1 regulates TFEB-induced autophagy-lysosome pathway

Youbao Sha et al.

EMBO JOURNAL (2017)

Review Cell Biology

TFEB and TFE3: Linking Lysosomes to Cellular Adaptation to Stress

Nina Raben et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32 (2016)

Article Biochemistry & Molecular Biology

Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB

Matthew A. Gray et al.

CURRENT BIOLOGY (2016)

Article Biochemistry & Molecular Biology

TFEB and TFE3 are novel components of the integrated stress response

Jose A. Martina et al.

EMBO JOURNAL (2016)

Article Cell Biology

Protein kinase C controls lysosome biogenesis independently of mTORC1

Yang Li et al.

NATURE CELL BIOLOGY (2016)

Article Cell Biology

An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense

Mehran Najibi et al.

CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells

Benoit Marchand et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Cell Biology

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

Diego L. Medina et al.

NATURE CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

The Multifunctional Protein Fused in Sarcoma (FUS) Is a Coactivator of Microphthalmia-associated Transcription Factor (MITF)

Agnieszka Bronisz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Cell Biology

Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

Jose A. Martina et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre et al.

EMBO JOURNAL (2012)

Article Biochemistry & Molecular Biology

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Agnes Roczniak-Ferguson et al.

SCIENCE SIGNALING (2012)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Article Biochemical Research Methods

Fast and accurate short read alignment with Burrows-Wheeler transform

Heng Li et al.

BIOINFORMATICS (2009)

Article Biotechnology & Applied Microbiology

Model-based Analysis of ChIP-Seq (MACS)

Yong Zhang et al.

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Eos, MITF, and PU.1 recruit corepressors to osteoclast-specific genes in committed myeloid progenitors

Rong Hu et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biochemistry & Molecular Biology

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation

Sudarshana M. Sharma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

Mitogen-activated protein kinases in apoptosis regulation

T Wada et al.

ONCOGENE (2004)

Review Genetics & Heredity

Melanocytes and the Microphthalmia transcription factor network

E Steingrimsson et al.

ANNUAL REVIEW OF GENETICS (2004)

Article Multidisciplinary Sciences

Mammalian MAP kinase signalling cascades

LF Chang et al.

NATURE (2001)