Host-guest Assembly Based on γ-Cyclodextrin-functionalized Multiwalled Carbon Nanotubes for Rutin Electrochemical Sensing

Here, we report multiwalled carbon nanotubes (MWCNTs) functionalized with gamma-cyclodextrins (gamma CD) as a novel electrochemical strategy for Rutin determination, showing superior performance than beta-cyclodextrins (beta CD) modified MWCNTs, suggesting an adequate environment for host-guest interactions. Under optimized conditions, the sensor showed a linear range of 39-975 nmol L-1 and a limit of detection of 7 nmol L-1. When tested with quercetin, catechin, and caffeine, the platform presented high selectivity with an interference response <10 %. The method was employed to quantify Rutin in spiked pharmaceutical and herbal extracts, providing recovery of 93-98.4 %. Also, HPLC-PDA confirmed the method's accuracy.

Automated summary

In this study, multiwalled carbon nanotubes functionalized with gamma-cyclodextrins were used as an electrochemical strategy for Rutin determination. The sensor showed a linear range of 39-975 nmol L-1 and a limit of detection of 7 nmol L-1. High selectivity and accuracy were confirmed through testing with other compounds and comparison with HPLC-PDA.