Journal
ELECTROANALYSIS
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.202200390
Keywords
Supramolecular Chemistry; Multi-walled Carbon Nanotubes; Rutin; Host-guest; Square Wave Voltammetry; Flavonoids; Pharmaceutical Compounds
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [465389/2014-7]
- Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientificoe Tecnologico do Maranhao (FAPEMA) [INFRA-02264/21]
- Coordenacao de Aperfeicoamento de Pessoalde Nivel Superior (CAPES) [001, 23038.019471/2018-88]
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In this study, multiwalled carbon nanotubes functionalized with gamma-cyclodextrins were used as an electrochemical strategy for Rutin determination. The sensor showed a linear range of 39-975 nmol L-1 and a limit of detection of 7 nmol L-1. High selectivity and accuracy were confirmed through testing with other compounds and comparison with HPLC-PDA.
Here, we report multiwalled carbon nanotubes (MWCNTs) functionalized with gamma-cyclodextrins (gamma CD) as a novel electrochemical strategy for Rutin determination, showing superior performance than beta-cyclodextrins (beta CD) modified MWCNTs, suggesting an adequate environment for host-guest interactions. Under optimized conditions, the sensor showed a linear range of 39-975 nmol L-1 and a limit of detection of 7 nmol L-1. When tested with quercetin, catechin, and caffeine, the platform presented high selectivity with an interference response <10 %. The method was employed to quantify Rutin in spiked pharmaceutical and herbal extracts, providing recovery of 93-98.4 %. Also, HPLC-PDA confirmed the method's accuracy.
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