4.7 Article

Exosomal miR-125a-5p regulates T lymphocyte subsets to promote silica-induced pulmonary fibrosis by targeting TRAF6

Related references

Note: Only part of the references are listed.
Article Environmental Sciences

PPARγ/LXRα axis mediated phenotypic plasticity of lung fibroblasts in silica-induced experimental silicosis

Yuanmeng Qi et al.

Summary: Silicosis is a disease caused by long-term inhalation of dust with excessively high content of free SiO2. This study investigated the role of PPAR gamma/LXR alpha in the biological regulation and potential therapeutic target for silicosis by inhibiting the transdifferentiation of lung fibroblasts into myofibroblasts.

ENVIRONMENTAL POLLUTION (2022)

Article Medicine, Research & Experimental

PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis

Youliang Zhao et al.

Summary: This study demonstrates the potential value of immune checkpoint inhibitors, particularly PD-1/PD-L1 inhibitors, in the treatment of silica-induced pulmonary fibrosis. The findings suggest that these inhibitors can modulate immune system disruption caused by silica exposure and provide new ideas for the treatment of fibrosis-related diseases.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Article Pharmacology & Pharmacy

TRAF6 Suppresses the Development of Pulmonary Fibrosis by Attenuating the Activation of Fibroblasts

Jiali Min et al.

Summary: This study explores the role of TNF receptor-associated factor 6 (TRAF6) in the pathogenesis of pulmonary fibrosis (PF). It demonstrates that decreased expression of TRAF6 in lung fibroblasts is essential for the progression of PF. Moreover, overexpression of TRAF6 can reverse the activation of myofibroblasts in PF mice by suppressing Wnt/beta-catenin signaling. The study also reveals a negative correlation between the abundance of TRIB3 and TRAF6 in lung fibroblasts, suggesting that disruption of the TRIB3-TRAF6 interaction could be a potential therapeutic strategy for fibroproliferative lung diseases.

FRONTIERS IN PHARMACOLOGY (2022)

Review Rheumatology

Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)

Paolo Spagnolo et al.

Summary: This study discusses the different types of interstitial lung diseases (ILDs) and their association with autoimmune and connective tissue diseases (CTDs), as well as introduces drug treatment studies for some fibrosing ILDs. It emphasizes the importance of fibrosis in ILDs.

ANNALS OF THE RHEUMATIC DISEASES (2021)

Article Biotechnology & Applied Microbiology

RPARP-AS1/miR125a-5p Axis Promotes Cell Proliferation, Migration and Invasion in Colon Cancer

Yongjun Ren et al.

Summary: The study revealed that RPARP-AS1 was up-regulated in CRC tissues and cell lines, correlating with poor prognosis. Knockdown of RPARP-AS1 inhibited CRC cell proliferation, migration, and invasion. RPARP-AS1 functions as a ceRNA to sponge miR-125a-5p, promoting CRC progression.

ONCOTARGETS AND THERAPY (2021)

Review Allergy

Silica-related diseases in the modern world

Ryan F. Hoy et al.

ALLERGY (2020)

Article Environmental Sciences

Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation

Di Wang et al.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2020)

Article Critical Care Medicine

Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy

Peter M. George et al.

LANCET RESPIRATORY MEDICINE (2020)

Review Immunology

T Cells in Fibrosis and Fibrotic Diseases

Mengjuan Zhang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Pharmacology & Pharmacy

Therapeutic Potential of Exosomes in Pulmonary Fibrosis

Linshen Xie et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Gastroenterology & Hepatology

MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-kappa B-TNF alpha pathway

Tianpeng Zhang et al.

JOURNAL OF HEPATOLOGY (2019)

Article Biochemistry & Molecular Biology

MiR125a-5p Acting as a Novel Gab2 Suppressor Inhibits Invasion of Glioma

Lei Sun et al.

MOLECULAR CARCINOGENESIS (2016)

Article Immunology

Silica, Silicosis, and Autoimmunity

Kenneth Michael Pollard

FRONTIERS IN IMMUNOLOGY (2016)

Article Pharmacology & Pharmacy

Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice

Ying Chen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Review Cell Biology

Roles of T lymphocytes in pulmonary fibrosis

Irina G. Luzina et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

Article Physiology

Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles

V Barbarin et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2005)