4.7 Review

CCT251545 enhances drug delivery and potentiates chemotherapy in multidrug-resistant cancers by Rac1-mediated macropinocytosis

Related references

Note: Only part of the references are listed.
Article Medicine, Research & Experimental

Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy

Zhe Zhang et al.

Summary: The study identified a drug-tolerant persister (DTP) state in multidrug-resistant (MDR) cancer cells as a tolerance response to combination treatment, partially preventing chemotherapy-induced oxidative stress by promoting vitamin E uptake. The NRF2 transcriptionally regulated NPC1L1 by binding to its promoter, and decreased DNA methylation was also related to this process. Triple-combination therapy with chemotherapeutic agents, verapamil, and ezetimibe demonstrated significant anti-tumor effects and prevented tumor recurrence in mice.

EMBO MOLECULAR MEDICINE (2022)

Review Oncology

Exploiting cancer's drinking problem: regulation and therapeutic potential of macropinocytosis

Joseph Puccini et al.

Summary: This review discusses the recent advances in understanding macropinocytosis, including its regulatory pathways, its contribution to the metabolic fitness of cancer cells, and its therapeutic potential.

TRENDS IN CANCER (2022)

Article Multidisciplinary Sciences

Patient-derived xenografts and organoids model therapy response in prostate cancer

Sofia Karkampouna et al.

Summary: Therapy resistance and metastatic processes in prostate cancer remain a challenge, but a new patient-derived xenograft model and organoid system may offer a personalized approach to treatment. This study reveals potential new strategies for screening drug responses and targeting advanced cases with acquired resistance to standard therapies.

NATURE COMMUNICATIONS (2021)

Article Nanoscience & Nanotechnology

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer

Ran Li et al.

Summary: The study demonstrates that the accumulation of nanoparticle albumin bound paclitaxel in tumors is influenced by signaling molecules related to nutrient uptake and processing, which can be reprogrammed to enhance the drug's efficacy.

NATURE NANOTECHNOLOGY (2021)

Review Gastroenterology & Hepatology

Harnessing metabolic dependencies in pancreatic cancers

Joel Encarnacion-Rosado et al.

Summary: PDAC is a highly aggressive cancer with unique tumor microenvironment, which can reprogram metabolism to adapt to the harsh conditions and develop therapeutic resistance. PDAC cells survive in the hostile environment by using non-canonical metabolic pathways and scavenging pathways.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

Review Nutrition & Dietetics

Advances in NAD-Lowering Agents for Cancer Treatment

Moustafa S. Ghanem et al.

Summary: NAD is essential for cancer cell survival and proliferation, making inhibition of its production pathway a promising anti-cancer strategy. Research has focused on targeting the key enzyme NAMPT, but clinical activity of inhibitors has been limited, indicating a need for refinement.

NUTRIENTS (2021)

Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

Article Multidisciplinary Sciences

Macropinocytosis confers resistance to therapies targeting cancer anabolism

Vaishali Jayashankar et al.

NATURE COMMUNICATIONS (2020)

Review Pharmacology & Pharmacy

Recent Advances in NAMPT Inhibitors: A Novel Immunotherapic Strategy

Ubaldina Galli et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Leo Aubert et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Emerging role of tumor cell plasticity in modifying therapeutic response

Siyuan Qin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Biochemistry & Molecular Biology

NAD+metabolism: pathophysiologic mechanisms and therapeutic potential

Na Xie et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Endocrinology & Metabolism

NAD(+) homeostasis in health and disease

Elena Katsyuba et al.

NATURE METABOLISM (2020)

Article Cell Biology

NAD+ metabolism governs the proinflammatory senescence-associated secretome

Timothy Nacarelli et al.

NATURE CELL BIOLOGY (2019)

Review Pharmacology & Pharmacy

What sustains the multidrug resistance phenotype beyond ABC efflux transporters? Looking beyond the tip of the iceberg

Teodora Alexa-Stratulat et al.

DRUG RESISTANCE UPDATES (2019)

Review Pharmacology & Pharmacy

The multi-factorial nature of clinical multidrug resistance in cancer

Yehuda G. Assaraf et al.

DRUG RESISTANCE UPDATES (2019)

Article Multidisciplinary Sciences

Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells

Ritesh K. Srivastava et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemical Research Methods

Decreased NAD Activates STAT3 and Integrin Pathways to Drive Epithelial-Mesenchymal Transition

Weixuan Wang et al.

MOLECULAR & CELLULAR PROTEOMICS (2018)

Review Oncology

Revisiting the role of ABC transporters in multidrug-resistant cancer

Robert W. Robey et al.

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Shawn M. Davidson et al.

NATURE MEDICINE (2017)

Review Endocrinology & Metabolism

Macropinocytosis: A Metabolic Adaptation to nutrient Stress in Cancer

Maria Victoria Recouvreux et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

Review Biochemistry & Molecular Biology

Targeting Metabolism for Cancer Therapy

Alba Luengo et al.

CELL CHEMICAL BIOLOGY (2017)

Review Pharmacology & Pharmacy

Toward a Better Understanding of the Complexity of Cancer Drug Resistance

Michael M. Gottesman et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 56 (2016)

Article Chemistry, Medicinal

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Aurelie Mallinger et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Trevor Dale et al.

NATURE CHEMICAL BIOLOGY (2015)

Review Endocrinology & Metabolism

Physiological and pathophysiological roles of NAMPT and NAD metabolism

Antje Garten et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

Review Multidisciplinary Sciences

NAD+ in aging, metabolism, and neurodegeneration

Eric Verdin

SCIENCE (2015)

Article Biochemistry & Molecular Biology

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao et al.

Article Multidisciplinary Sciences

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso et al.

NATURE (2013)

Review Oncology

The NAD metabolome - a key determinant of cancer cell biology

Alberto Chiarugi et al.

NATURE REVIEWS CANCER (2012)

Review Biochemistry & Molecular Biology

The P-glycoprotein multidrug transporter

Frances J. Sharom

ESSAYS IN BIOCHEMISTRY: ABC TRANSPORTERS (2011)

Review Cell Biology

Macropinocytosis: an endocytic pathway for internalising large gulps

Jet Phey Lim et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

Review Medicine, General & Internal

Sirtuins, Aging, and Medicine

Leonard Guarente

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Multidisciplinary Sciences

Multiple molecular mechanisms for multidrug resistance transporters

Christopher F. Higgins

NATURE (2007)

Article Chemistry, Medicinal

The discovery of ezetimibe: A view from outside the receptor

JW Clader

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Review Oncology

The role of ABC transporters in clinical practice

GD Leonard et al.

ONCOLOGIST (2003)

Review Oncology

Multidrug resistance in cancer: Role of ATP-dependent transporters

MM Gottesman et al.

NATURE REVIEWS CANCER (2002)