Regulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia

Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregnancy. The renin-angiotensin-aldosterone system (RAAS) is one of the first to recognize pregnancy and is an important regulator of blood pressure. The placenta has its own RAAS, the role of which in the development of PE is not fully understood. In this work, for the first time, we characterized the expression of RAAS components and miRNAs controlling it in the placenta at various times of PE manifestation. The data obtained will allow the development of a new strategy in the future for the search for therapeutic agents for patients suffering from PE and cardiovascular diseases.

Automated summary

Preeclampsia is a dangerous complication of pregnancy characterized by hypertension, proteinuria, and multiple organ failure. This study characterized the expression of RAAS components and miRNAs controlling it in the placenta during different stages of preeclampsia manifestation. The findings will contribute to the future development of therapeutic strategies for preeclampsia and cardiovascular diseases.