4.6 Article

Oncolytic Zika Virus: New Option for Glioblastoma Treatment

Related references

Note: Only part of the references are listed.
Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Article Oncology

Leveraging Allele-Specific Expression for Therapeutic Response Gene Discovery in Glioblastoma

Arko Sen et al.

Summary: Glioblastoma, the most common primary malignant brain tumor in adults, lacks effective treatments. By investigating allele-specific expression, researchers have identified genes, including SLFN11, that are dysregulated in glioblastoma stem cells and play a role in drug resistance and susceptibility to the Zika virus.

CANCER RESEARCH (2022)

Article Oncology

The combination therapy of oncolytic HSV-1 armed with anti-PD-1 antibody and IL-12 enhances anti-tumor efficacy

Xin Xie et al.

Summary: The study suggests that combination therapy with engineered oncolytic viruses may serve as a potent immunotherapy strategy for cancer patients, especially those resistant to PD-1/PD-L1 blockade therapy.

TRANSLATIONAL ONCOLOGY (2022)

Review Oncology

Implications of immune cells in oncolytic herpes simplex virotherapy for glioma

Yoshihiro Otani et al.

Summary: Despite current progress in treatment, glioblastoma remains a lethal primary malignant tumor. Immunotherapy has shown effectiveness in multiple malignancies but has not been successful in clinical trials for glioblastoma. Oncolytic virotherapy has shown promise in treating glioblastoma by modifying the tumor microenvironment and recruiting immune cells, although fine-tuning of the immune response is crucial for maximizing therapeutic efficacy.

BRAIN TUMOR PATHOLOGY (2022)

Article Genetics & Heredity

Gospel of malignant Glioma: Oncolytic virus therapy

Jinjian Li et al.

Summary: Glioma, the most common intracranial malignant tumor, is a significant health challenge due to its impact on brain function. The current treatments, including surgery, radiotherapy, and chemotherapy, have limited efficacy. Researchers have explored the use of oncolytic viruses (OVs) as a novel treatment approach. OVs work by activating the immune system and inducing tumor cell apoptosis. However, the classification of OVs is still unclear, and the clinical application faces challenges.
Article Oncology

Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma

Lishu Chen et al.

Summary: Zika virus treatment can enhance immune cell infiltration and activation in glioblastoma and inhibit tumor growth. Additionally, Zika virus can activate the interferon signaling pathway in glioblastoma cells. This therapy can improve the sensitivity of glioblastoma to immune checkpoint blockade.

MOLECULAR THERAPY-ONCOLYTICS (2022)

Review Clinical Neurology

Oncolytic Viral Therapy for Malignant Glioma and Their Application in Clinical Practice

Madison L. Shoaf et al.

Summary: Oncolytic virotherapy is a promising modality that uses engineered viruses to combat tumors through direct oncolysis and immune response stimulation, but clinical outcomes vary. This review summarizes relevant studies, discusses technical aspects, emphasizes practical considerations, and explores potential future directions for maximizing efficacy.

NEUROTHERAPEUTICS (2022)

Review Oncology

Tumor-Treating Fields in Glioblastomas: Past, Present, and Future

Xiaopeng Guo et al.

Summary: Glioblastoma (GBM) is a common malignant primary brain tumor with a low 5-year survival rate. Tumor-treating fields (TTFields) have emerged as the fourth most effective treatment option for GBMs, prolonging patient survival and showing acceptable adverse events. TTFields disrupts cell mitosis, delays DNA repair, enhances autophagy, inhibits cell metabolism and angiogenesis, and limits cancer cell migration. It also strengthens antitumor immunity, increases cell membrane and blood-brain barrier permeability, and disrupts DNA-damage-repair processes. However, the overall acceptance of TTFields in clinical practice is still low. This review provides an updated understanding of the mechanism of action, efficacy, safety, clinical concerns, and future perspectives of TTFields in GBMs.

CANCERS (2022)

Article Medicine, Research & Experimental

Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade

Sharmila Nair et al.

Summary: Zika virus targets GBM stem cells and prevents tumor growth by recruiting CD8(+) T cells and myeloid cells. While anti-PD-1 antibody alone moderately improves survival, combining it with ZIKV treatment significantly increases survival rate. Immune-sensitized ZIKV strain shows promise for safe and effective combination therapy with immunotherapies for GBM patients.

JCI INSIGHT (2021)

Article Clinical Neurology

Safety and interim survival data after intracranial administration of M032, a genetically engineered oncolytic HSV-1 expressing IL-12, in pet dogs with sporadic gliomas

Nidal B. Omar et al.

Summary: In a phase I clinical trial, twenty-five pet dogs with gliomas were treated with a genetically engineered HSV-1 vector expressing interleukin-12, resulting in a median overall survival of 151 days. The combination of surgery and oncolytic viral therapy did not cause harm and may have contributed to prolonged survival in dogs with spontaneous gliomas. Further analysis is needed to understand the impact of this treatment on tumors and the immune system, with the goal of translating these findings to improve outcomes in both humans and pet dogs with gliomas.

NEUROSURGICAL FOCUS (2021)

Editorial Material Multidisciplinary Sciences

Oncolytic virotherapy as immunotherapy

Alan Melcher et al.

SCIENCE (2021)

Article Oncology

AXL receptor is required for Zika virus strain MR-766 infection in human glioblastoma cell lines

Samuel D. Zwernik et al.

Summary: Recent studies have shown that Zika virus can enter human glioblastoma cells through the AXL receptor, leading to productive infection, while inhibition of the AXL receptor can significantly weaken virus entry. Knocking out the AXL gene in GBM cells completely eliminates Zika virus infection, inhibits viral replication, and reduces apoptosis. Introducing the AXL receptor into non-expressing cell lines makes the cells susceptible to Zika virus infection.

MOLECULAR THERAPY-ONCOLYTICS (2021)

Article Medicine, General & Internal

Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas

G. K. Friedman et al.

Summary: The study conducted a phase 1 trial of G207 in children and adolescents with recurrent or progressive supratentorial brain tumors, showing an acceptable adverse-event profile and evidence of responses. G207 was able to convert immunologically cold tumors to hot.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

Brain and other central nervous system tumor statistics, 2021

Kimberly D. Miller et al.

Summary: Brain and other CNS tumors are highly fatal cancers in the United States, with different incidence rates and survival rates among different races and age groups. Survival disparities, especially in childhood tumors, highlight the importance of providing more resources to advance research and understand the reasons behind differences in brain tumor occurrence, especially among rarer subtypes and understudied populations.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Virology

African-Lineage Zika Virus Replication Dynamics and Maternal-Fetal Interface Infection in Pregnant Rhesus Macaques

Chelsea M. Crooks et al.

Summary: The study suggests that ZIKV of any genetic lineage poses a threat to pregnant individuals and their infants, but the African-lineage ZIKV did not demonstrate more severe pathogenic features compared to the Asian-lineage.

JOURNAL OF VIROLOGY (2021)

Article Oncology

The immune landscape of common CNS malignancies: implications for immunotherapy

Martina Ott et al.

Summary: Immunotherapy has shown remarkable therapeutic responses in treating various cancers, with exceptions like glioblastoma. Immune profiling of samples from central nervous system tumors and brain metastases has revealed fundamental differences in immune composition, providing guidance for novel immunotherapeutic strategies.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Oncology

The blood-tumour barrier in cancer biology and therapy

Patricia S. Steeg

Summary: The blood-brain barrier plays a crucial role in maintaining normal brain function, but modifications in primary brain tumors and brain metastases result in the blood-tumor barrier, further limiting the penetration of therapeutic agents. This challenge highlights the importance of understanding and overcoming the structural and functional complexities of the blood-tumor barrier for improving cancer therapy and patient outcomes.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

Review Virology

Oncolytic Viruses for Malignant Glioma: On the Verge of Success?

Yogesh R. Suryawanshi et al.

Summary: Glioblastoma is a challenging tumor type to treat with conventional therapy, but immunotherapeutic agents have shown limited success and further optimization is needed. Some oncolytic viruses have demonstrated the ability to infect tumors in malignant glioma patients, but hurdles like the blood-brain barrier and tumor heterogeneity can reduce their efficacy. Strategies are being developed to optimize oncolytic virotherapy outcomes.

VIRUSES-BASEL (2021)

Review Virology

The Current Landscape of Oncolytic Herpes Simplex Viruses as Novel Therapies for Brain Malignancies

Joshua D. Bernstock et al.

Summary: Despite advances in surgical resection and chemoradiation, high-grade brain tumors remain associated with significant morbidity/mortality, necessitating novel therapeutic strategies. Immunotherapy and immunovirotherapy are among the forefront of these new approaches being investigated for incurable brain tumors. This mini review focuses on oncolytic herpes viruses (oHSV) currently in clinical trials.

VIRUSES-BASEL (2021)

Article Cell & Tissue Engineering

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

Zhe Zhu et al.

CELL STEM CELL (2020)

Article Biotechnology & Applied Microbiology

Safety, Tumor Reduction, and Clinical Impact of Zika Virus Injection in Dogs with Advanced-Stage Brain Tumors

Carolini Kaid et al.

MOLECULAR THERAPY (2020)

Article Multidisciplinary Sciences

Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Mayank Srivastava et al.

NATURE COMMUNICATIONS (2020)

Review Virology

Construction of Stable Reporter Flaviviruses and Their Applications

Coleman Baker et al.

VIRUSES-BASEL (2020)

Review Oncology

Brain immunology and immunotherapy in brain tumours

John H. Sampson et al.

NATURE REVIEWS CANCER (2020)

Article Medicine, Research & Experimental

Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors

Niklas Schaefer et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Review Immunology

Mechanisms of immunotherapy resistance: lessons from glioblastoma

Christopher M. Jackson et al.

NATURE IMMUNOLOGY (2019)

Review Biotechnology & Applied Microbiology

Optimizing oncolytic virotherapy in cancer treatment

Kevin Harrington et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Biochemistry & Molecular Biology

Zika virus NS5 protein inhibits cell growth and invasion of glioma

Hongjian Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Medicine, General & Internal

Zika Virus Infection - After the Pandemic

Didier Musso et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Recurrent Glioblastoma Treated with Recombinant Poliovirus

Annick Desjardins et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Biotechnology & Applied Microbiology

Talimogene laherparepvec: First in class oncolytic virotherapy

Robert M. Conry et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2018)

Review Biochemistry & Molecular Biology

Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier

Martina Da Ros et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Oncology

Oncolytic viruses and checkpoint inhibitors: combination therapy in clinical trials

Christopher J. LaRocca et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2018)

Review Oncology

Tumor-Treating Fields: A Fourth Modality in Cancer Treatment

Elijah J. Mun et al.

CLINICAL CANCER RESEARCH (2018)

Article Immunology

Zika virus has oncolytic activity against glioblastoma stem cells

Zhe Zhu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication

Pavithra L. Chavali et al.

SCIENCE (2017)

Review Immunology

T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints

Reza Mirzaei et al.

TRENDS IN IMMUNOLOGY (2017)

Article Clinical Neurology

Neurologic Complications Associated With the Zika Virus in Brazilian Adults

Ivan Rocha Ferreira da Silva et al.

JAMA NEUROLOGY (2017)

Article Cell & Tissue Engineering

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

Hengli Tang et al.

CELL STEM CELL (2016)

Article Cell & Tissue Engineering

Zika Virus Disrupts Neural Progenitor Development and Leads to Microcephaly in Mice

Cui Li et al.

CELL STEM CELL (2016)

Article Cell & Tissue Engineering

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

Tomasz J. Nowakowski et al.

CELL STEM CELL (2016)

Article Multidisciplinary Sciences

Structure of the thermally stable Zika virus

Victor A. Kostyuchenko et al.

NATURE (2016)

Article Multidisciplinary Sciences

Zika virus cell tropism in the developing human brain and inhibition by azithromycin

Hanna Retallack et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

The 3.8 Å resolution cryo-EM structure of Zika virus

Devika Sirohi et al.

SCIENCE (2016)

Article Oncology

Glioblastoma: Overview of Disease and Treatment

Mary Elizabeth Davis

CLINICAL JOURNAL OF ONCOLOGY NURSING (2016)

Article Medicine, General & Internal

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma A Randomized Clinical Trial

Roger Stupp et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Virology

Biology of Zika Virus Infection in Human Skin Cells

Rodolphe Hamel et al.

JOURNAL OF VIROLOGY (2015)

Review Biotechnology & Applied Microbiology

Oncolytic viruses: a new class of immunotherapy drugs

Howard L. Kaufman et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Biotechnology & Applied Microbiology

Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor

Kurt Schoenfeld et al.

MOLECULAR THERAPY (2015)

Article Pharmacology & Pharmacy

Promising approaches to circumvent the blood-brain barrier: progress, pitfalls and clinical prospects in brain cancer

Iason T. Papademetriou et al.

THERAPEUTIC DELIVERY (2015)

Article Multidisciplinary Sciences

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

Anoop P. Patel et al.

SCIENCE (2014)

Article Biotechnology & Applied Microbiology

Phase 1 Clinical Trial of Intratumoral Reovirus Infusion for the Treatment of Recurrent Malignant Gliomas in Adults

Kimberly P. Kicielinski et al.

MOLECULAR THERAPY (2014)

Article Oncology

Prognostic value of Musashi-1 in gliomas

Rikke H. Dahlrot et al.

JOURNAL OF NEURO-ONCOLOGY (2013)

Article Virology

Flaviviruses: braking the entering

Theodore C. Pierson et al.

CURRENT OPINION IN VIROLOGY (2013)

Article Biotechnology & Applied Microbiology

Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme

AI Freeman et al.

MOLECULAR THERAPY (2006)

Article Oncology

MTH-68/H oncolytic viral treatment in human high-grade gliomas

LK Csatary et al.

JOURNAL OF NEURO-ONCOLOGY (2004)

Article Oncology

Poliovirus receptor CD155-targeted oncolysis of glioma

MK Merrill et al.

NEURO-ONCOLOGY (2004)

Article Multidisciplinary Sciences

Intergeneric poliovirus recombinants for the treatment of malignant glioma

M Gromeier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)