FBXO22 Accelerates Pancreatic Cancer Growth by Deactivation of the Hippo Pathway via Destabilizing LATS2

Article Oncology

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2

Wen-Hsuan Yang et al.

Summary: The study reveals that YAP promotes ferroptosis by regulating SKP2, suggesting novel therapeutic options for YAP-driven tumors.

MOLECULAR CANCER RESEARCH (2021)

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Article Multidisciplinary Sciences

The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage

Sarmishtha De et al.

Summary: High expression of PD-L1 in cancer cells can lead to resistance to DNA-damaging therapies, while activated FBXO22 sensitizes NSCLC cells and increases their sensitivity to DNA damage by degrading PD-L1. Inhibiting CDK5 or reducing its expression can increase the level of FBXO22, decrease PD-L1 expression, and enhance sensitivity of cells to DNA damage.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Cardiac & Cardiovascular Systems

Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

Vivek P. Singh et al.

Summary: The study found that the Hippo pathway intermediate Tead1 can enhance the efficiency of induced cardiomyocyte generation, showing significant effects on both fibroblasts and cardiac fibroblasts. By replacing TBX5 and regulating the expression levels of cardio-differentiation genes and mitochondrial biogenesis regulator genes, Tead1 helps increase the expression of cardiomyocyte markers.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2021)

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Article Oncology

Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer

Suman Mohajan et al.

Summary: The Hippo pathway serves as a master regulator of various cellular processes and its deregulation is associated with cancer. Despite the importance, the detailed functions of the components of the mammalian Hippo pathway in tumor biology are still unclear.

CANCER LETTERS (2021)

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Article Medicine, Research & Experimental

E3 ubiquitin ligase TRIM29 promotes pancreatic cancer growth and progression via stabilizing Yes-associated protein 1

Xueqiang Deng et al.

Summary: The study found that TRIM29 and YAP1 are significantly upregulated in PC patient samples, and TRIM29 expression is closely related to a malignant phenotype and poorer overall survival of PC patients. Functional experiments showed that TRIM29 knockdown inhibited cell growth, arrested cell cycle progression, and promoted cell apoptosis in PC cells.

JOURNAL OF TRANSLATIONAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

YAP1 is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Pancreatic Cancer

Kai Sun et al.

Summary: YAP1 is differently expressed in various cancers, particularly elevated in pancreatic cancer. Its expression is correlated with patient outcomes and tumor immune cell infiltration, making it a valuable prognostic biomarker.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Biochemistry & Molecular Biology

E3 ubiquitin ligases: styles, structures and functions

Quan Yang et al.

Summary: E3 ubiquitin ligases are key enzymes in the ubiquitination process, playing a crucial role in transferring ubiquitin protein to the lysine site of targeted substrates. Their importance in regulating cellular activities and responding to cancer development is increasingly recognized.

MOLECULAR BIOMEDICINE (2021)

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Article Multidisciplinary Sciences