Deposition of Ni/RGO nanocomposite on conductive cotton fabric as non-enzymatic wearable electrode for electrochemical sensing of uric acid in sweat

In this work, the development of a wearable electrochemical sensor for the direct measurement of uric acid in human sweat is reported. The preparation of Ni and reduced graphene oxide composites with stable electrocatalytic responses, as well as their structural characterization, was carried out. The electrochemical properties of the Ni/RGO/CCF modified electrode of conductive cotton fabric were investigated for the purpose of uric acid determination using differential pulse voltammetry. On a scale ranging from 10 mu M to 60 mu M, the electrode signals (Ni/RGO/CCF) were found to be linearly related to the uric acid concentration. It was possible to attain a low limit of detection (5.083 mu M) with good reproducibility. Finally, an interference investigation and real-time sample analysis of the modified electrode demonstrate that it has a great potential for use as disposable sensors in biological systems.

Automated summary

This work presents the development of a wearable electrochemical sensor for direct measurement of uric acid in human sweat. The study involved the preparation and characterization of Ni and reduced graphene oxide composites with stable electrocatalytic responses. The electrochemical properties of the modified electrode were investigated, and it was found to have linear response to uric acid concentration. The sensor demonstrated a low detection limit and good reproducibility, and exhibited great potential as a disposable sensor in biological systems.