Reduced heart rate variability in people with type 1 diabetes and elevated diabetes distress: Results from the longitudinal observational DIA-LINK1 study

Aims: People with type 1 diabetes have a higher risk for cardiovascular disease (CVD). Reduced heart rate variability (HRV) is a clinical marker for CVD. In this observational study using continuous HRV measurement across 26 days, we investigated whether psychological stressors (diabetes distress, depressive symptoms) and glycaemic parameters (hypo- and hyperglycaemic exposure, glycaemic variability and HbA(1c)) are associated with lower HRV in people with type 1 diabetes.Methods: Data from the non-interventional prospective DIA-LINK1 study were analysed. At baseline, depressive symptoms and diabetes distress were assessed. Glucose values and HRV were recorded daily for 26 days using continuous glucose monitoring (CGM) and a wrist-worn health tracker respectively. Multilevel modelling with participant as nesting factor was used to analyse associations between day-to-day HRV and diabetes distress, depressive symptoms and CGM-derived parameters.Results: Data from 149 participants were analysed (age: 38.3 +/- 13.1 years, HbA(1c): 8.6 +/- 1.9%). Participants with elevated diabetes distress had a significantly lower HRV across the 26 days compared to participants without elevated distress (beta = -0.28; p = 0.004). Elevated depressive symptoms were not significantly associated with HRV (beta = -0.18; p = 0.074). Higher daily exposure to hyperglycaemia (beta = -0.44; p = 0.044), higher average exposure to hypoglycaemia (beta = -0.18; p = 0.042) and higher HbA(1c) (beta = -0.20; p = 0.018) were associated with reduced HRV across the 26 days. Sensitivity analysis with HRV averaged across all days corroborated these results.Conclusions: Diabetes distress is a clinically meaningful psychosocial stressor that could play a role in the cardiovascular health of people with type 1 diabetes. These findings highlight the need for integrated psychosocial care in diabetes management.

Automated summary

In this observational study, the researchers investigated the association between psychological stressors (diabetes distress, depressive symptoms) and glycaemic parameters (hypo- and hyperglycaemic exposure, glycaemic variability and HbA(1c)) with reduced heart rate variability (HRV) in people with type 1 diabetes. The results showed that participants with elevated diabetes distress had significantly lower HRV, while elevated depressive symptoms were not significantly associated with HRV. Higher daily exposure to hyperglycaemia, higher average exposure to hypoglycaemia, and higher HbA(1c) were associated with reduced HRV.