Journal
DEVELOPMENT
Volume 149, Issue 23, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.200870
Keywords
Neural stem cell; Mitochondria; Oxidative phosphorylation; Mitochondrial morphology; Reactive oxygen species; Notch
Categories
Funding
- Wellcome Clinical Research Career Development Fellowship [219615/Z/19/Z]
- University of Cambridge
- Evelyn Trust Medical Research [21-25]
- Indian Institutes of Science Education and Research Pune
- Department of Biotechnology, Ministry of Science and Technology, India [BT/PR18898/MED/122/19/2016]
- Wellcome Trust [219615/Z/19/Z] Funding Source: Wellcome Trust
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Mitochondria play a central role in the behavior and fate decisions of neural stem cells, influencing cellular metabolism and the activity of chromatin-modifying enzymes.
Neural stem cells (NSCs) in the developing and adult brain undergo many different transitions, tightly regulated by extrinsic and intrinsic factors. While the role of signalling pathways and transcription factors is well established, recent evidence has also highlighted mitochondria as central players in NSC behaviour and fate decisions. Many aspects of cellular metabolism and mitochondrial biology change during NSC transitions, interact with signalling pathways and affect the activity of chromatin-modifying enzymes. In this Spotlight, we explore recent in vivo findings, primarily from Drosophila and mammalian model systems, about the role that mitochondrial respiration and morphology play in NSC development and function.
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