Novel antibacterial dental resin containing silanized hydroxyapatite nanofibers with remineralization capability

Objectives: Secondary caries is the primary issue that causes restoration failure. The ob-jectives of this study were to: (1) synthesize silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM); (2) evaluate the mechanical property, antibacterial ac-tivity, and remineralization capability of the novel dental resin containing s-HAFs@EM. Methods: s-HAFs were prepared by the solvothermal approach and loaded with EM. Characterization and antibacterial activity were evaluated. Subsequently, s-HAFs@EM were incorporated into dental resin at different mass fractions (5 %, 10 %, 15 %, and 20 %), and then they were submitted to characterization, including mechanical property, antibacterial activity, remineralization capability, and cytotoxicity. Results: s-HAFs@EM were successfully synthesized, and they exhibited excellent anti-bacterial activity. Resin containing 15 % s-HAFs@EM exhibited the best flexural strength (118.67 +/- 15.71 MPa) and elastic modulus (2.02 +/- 0.30 GPa) (P < 0.05), which were in-creased by 65.43 % and 90.7 %, compared to those of neat resin, respectively. Resin with 15-20 % s-HAFs@EM showed high antibacterial rate (> 85 %) when compared control group (P < 0.05). Furthermore, resin also exhibited a definite remineralization capability and good biosafety in vitro. Significance: This novel multifunctional resin with improved mechanical property, desirable antibacterial activity and remineralization capability is promising to combat secondary caries. (c) 2022 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.

Automated summary

This study synthesized dental resin containing silanized hydroxyapatite nanofibers loaded with erythromycin (s-HAFs@EM). The resin exhibited excellent mechanical properties, antibacterial activity, and remineralization capability, making it promising for combating secondary caries.