Journal
CYTOKINE
Volume 162, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2022.156088
Keywords
Cytokines; Glycogen storage disease; Chemokines
Ask authors/readers for more resources
This study found that cytokine levels were altered in patients with hepatic glycogen storage diseases (GSD), indicating an imbalance in the immunoregulation process. Moreover, neutrophils and some cytokines were affected by triglyceride levels. Future studies should consider this variable.
Introduction: Hepatic Glycogen Storage Diseases (GSD) are rare genetic disorders in which the gluconeogenesis pathway is impaired. Cytokines control virtually every aspect of physiology and may help to elucidate some unsolved questions about phenotypes presented by GSD patients.Methods: This was an exploratory study in which 27 GSD patients on treatment (Ia = 16, Ib = 06, III = 02, IX alpha = 03) and 24 healthy age-and sex-matched subjects had plasma samples tested for a panel of 20 cytokines (G-CSF, GM-CSF, IL-1 alpha,IL-1 beta, IL-4, IL-6, IL-8, IL-10, IL-13, IL-17A, GRO, IP-10/CXCL10, MCP-1/CCL2, MIP-1 alpha/CCL3, MIP-1 beta/CCL4, MDC/CCL22, IFN-gamma, TNF-alpha, TNF-beta, VEGF) through a multiplex kit and analyzed in comparison to controls and among patients, regarding to clinical features as anemia, hepatic adenocarcinoma and triglyceride levels.Results: Patients (GSD-Ia/III/IX) presented reduced levels of IL-4 (p = 0.040), MIP-1 alpha/CCL3 (p = 0.003), MDC/ CCL22 (p < 0.001), TNF-beta (p = 0.045) and VEGF (p = 0.043) compared to controls. When different types of GSD were compared, G-CSF was higher in GSD-Ib than-Ia (p < 0.001) and than-III/IX (p = 0.033) patients; IL-10 was higher in GSD-Ib than in GSD-Ia patients (p = 0.019); and GSD-III/IX patients had increased levels of IP-10/ CXCL10 than GSD-Ib patients (p = 0.019). When GSD-I patients were gathered into the same group and compared with GSD-III/IX patients, IP10/CXCL10 and MCP-1 were higher in the latter group (p = 0.005 and p = 0.013, respectively). GSD-I patients with anemia presented higher levels of IL-4 and MIP-1 alpha in comparison with patients who had not. Triglyceride level was correlated with neutrophil count and MDC levels on GSD-Ia patients without HCA.Conclusion: Altogether, altered levels of cytokines in GSD-I patients reflect an imbalance in immunoregulation process. This study also indicates that neutrophils and some cytokines are affected by triglyceride levels, and future studies on the theme should consider this variable.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available