Multi-target Polypharmacology of 4-aminoquinoline Compounds against Malaria, Tuberculosis and Cancer

Background Polypharmacology means drugs having interactions with multiple targets of a unique disease or many disease pathways. This concept has been greatly appreciated against complex diseases, such as oncology, CNS disorders, and anti-infectives. Methods The integration of diverse compounds available on public databases initiates polypharmacological drug discovery research. Immunocompromised patients may suffer from complex diseases. Multiple-component drug formulations may produce side effects and resistance issues due to unintended drug-target interactions. Results Polypharmacology remains a novel avenue to propose a more effective and less toxic treatment. The 4-amino quinoline scaffold has become an important construction motif for the development of new drugs against lifestyle diseases like cancer and infectious diseases like tuberculosis and malaria. Conclusion The present study is an attempt to explore the polypharmacological effects of 4-aminoquinoline drugs to combat malaria, cancer, and tuberculosis.

Automated summary

Polypharmacology refers to drugs that have interactions with multiple targets of a unique disease or many disease pathways. It is greatly appreciated in the treatment of complex diseases such as oncology, CNS disorders, and anti-infectives. The integration of diverse compounds from public databases is used for polypharmacological drug discovery research. The study aims to explore the polypharmacological effects of 4-aminoquinoline drugs in combating malaria, cancer, and tuberculosis.