Epigenetic Regulator ASXL2: Structure, Function and its Predictive Value in Diseases

ASXL2, as a transcription regulator, is a research hotspot for tumor detection. The aberrant expression of ASXL2 protein has been mainly implicated in malignant hematological and heart diseases. To further explore the predictive value of ASXL2 in diseases, we reviewed the structure and function of ASXL2 protein, the post-translational modification mechanism, and the expression of ASXL2 protein in the pathogenesis of different diseases to provide a theoretical basis and support for the development of future treatments.

Automated summary

ASXL2, a transcription regulator, is a hot topic in tumor detection. Aberrant expression of ASXL2 protein is mainly associated with malignant hematological and heart diseases. To explore the predictive value of ASXL2 in diseases, we reviewed its structure, function, post-translational modification mechanism, and expression in different disease pathogenesis, providing a theoretical basis and support for future treatments.