Related references
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Article
Immunology
Maria Zavala et al.
Summary: This study investigates the ongoing symptoms in children with COVID-19 and compares them with a symptomatic control group. The findings suggest that children with symptomatic COVID-19 have a slightly higher prevalence of ongoing symptoms compared to symptomatic controls. However, mental health symptoms were high and equally prevalent in both groups.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Luise Borch et al.
Summary: The study aimed to evaluate symptoms and duration of 'long COVID' in children. It found that most children recovered from symptoms within 1-5 months, suggesting that long COVID in children is rare and mainly of short duration.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Infectious Diseases
S. A. Behnood et al.
Summary: There is conflicting data on the long-term impact of SARS-CoV-2 infection in children and young people. This study assessed the evidence on long-term post-COVID symptoms in this population, including prevalence, risk factors, type, and duration. The findings suggest that the frequency of most reported persistent symptoms is similar in COVID-positive cases and controls.
JOURNAL OF INFECTION
(2022)
Article
Immunology
Petra Zimmermann et al.
Summary: The age-related difference in the severity of COVID-19 is most likely due to differences in innate, adaptive, and heterologous immunity, as well as endothelial and clotting function. Children have a stronger and faster innate immune response to SARS-CoV-2, while adults can have an overactive and less effective response. Exposure to other viruses and vaccines in children may contribute to cross-reactive antibodies and T cells against SARS-CoV-2.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Terence Stephenson et al.
Summary: The study found that adolescents aged 11-17 who tested positive for COVID-19 had similar symptoms to those who tested negative, but had a higher prevalence of single and, particularly, multiple symptoms at the time of testing and 3 months later.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Allergy
Patrick Taeschler et al.
Summary: This study reveals the presence of autoimmune-related antibody responses in COVID-19 patients, which are associated with increased antiviral humoral immune responses and inflammatory immune signatures.
Article
Pediatrics
Terence Stephenson et al.
Summary: The objective of this study was to establish a research definition for 'Long COVID (post-COVID-19 condition)' in children and young people (CYP) to enable comparison of research studies. A three-phase online Delphi process and a consensus meeting were conducted. The research definition proposed includes a minimum duration of 12 weeks of persisting physical symptoms after initial testing, impacting everyday functioning and not explained by an alternative diagnosis, in young people with a history of confirmed SARS-CoV-2 infection. This is the first research definition of Long COVID in CYP and aligns with the clinical case definition proposed by the WHO.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Respiratory System
Ismail M. Osmanov et al.
Summary: This study aimed to assess the long-term outcomes in children previously hospitalized with COVID-19 and found that a quarter of children experienced persistent symptoms months after hospitalization. Older age and allergic diseases were associated with a higher risk of persistent symptoms at follow-up.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Microbiology
Danilo Buonsenso et al.
Summary: This study conducted a survey on children with persistent symptoms after initial infection and found that symptoms such as fatigue, headache, muscle and joint pain, rashes, heart palpitations, lack of concentration, and short-term memory problems were particularly common. There is an urgent need for a better understanding of long coronavirus disease.
FUTURE MICROBIOLOGY
(2022)
Review
Microbiology
Danilo Buonsenso et al.
Summary: The article analyzes the evidence on pediatric long covid and lessons learnt from a pediatric post-covid unit in Rome, Italy. It also examines the long-term effects of other infectious diseases. Understanding the potential long-term consequences of this novel infection is crucial, as long-term effects of post-infectious diseases are not new phenomena.
FUTURE MICROBIOLOGY
(2022)
Letter
Virology
Panagiotis Giannos et al.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pediatrics
Melodie Aubart et al.
Summary: This study describes the neurological, radiological, and laboratory features of children with central nervous system (CNS) inflammatory diseases complicating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study identified several CNS inflammatory diseases in children, such as encephalopathy, cerebellar ataxia, acute disseminated encephalomyelitis, neuromyelitis optica spectrum disorder, or optic neuritis, following SARS-CoV-2 infection. The findings suggest that SARS-CoV-2 can trigger CNS inflammatory diseases in children.
JOURNAL OF PEDIATRICS
(2022)
Review
Immunology
Petra Zimmermann et al.
Summary: Accurately determining the risk of long COVID is challenging, especially in children and adolescents. Distinguishing symptoms related to long-term SARS-CoV-2 infection from pandemic-related symptoms is difficult. More robust data is needed to inform policy decisions.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pediatrics
Federico Scottoni et al.
Summary: This article reports two cases of intussusception in patients with SARS-CoV-2 infection and provides evidence of the presence of the virus in mesenteric and intestinal tissues of the patients.
Article
Multidisciplinary Sciences
Cara J. Bossley et al.
Summary: Most children and young people recover fully from SARS-CoV-2 infection without experiencing long-term symptoms of post-acute COVID-19 syndrome. However, a small number may have symptoms that last for more than 4 weeks, but most of these symptoms resolve within 3 months.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Trisha Patel et al.
Summary: This study compares classic viral myocarditis, MIS-C myocarditis, and COVID-19 vaccine-related myocarditis in terms of clinical presentation, course, and outcomes. Compared to classic myocarditis, patients with MIS-C myocarditis have better clinical outcomes, including rapid recovery of cardiac function. Patients with vaccine-related myocarditis have prompt resolution of symptoms and improvement of cardiac function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Ekaterina Pazukhina et al.
Summary: A significant proportion of COVID-19 patients experience post-COVID-19 condition (PCC) symptoms even 6 and 12 months after discharge, with females, individuals with pre-existing hypertension in adults, and those with neurological comorbidities or allergic respiratory diseases in children being at higher risk.
Article
Multidisciplinary Sciences
Jennifer Couzin-Frankel
Article
Multidisciplinary Sciences
Sandra Lopez-Leon et al.
Summary: This study systematically reviewed the prevalence and symptoms of long-COVID in children and adolescents. The prevalence of long-COVID was found to be 25.24%, with mood symptoms, fatigue, and sleep disorders being the most common manifestations.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Critical Care Medicine
Daniel Munblit et al.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Danilo Buonsenso et al.
Summary: This study investigated the cellular immunological responses of children with COVID-19, including those with acute infection, recovered individuals, and those with persistent symptoms. The study found that children with long-term COVID may have compromised adaptive immune responses and imbalances in T and B cell subsets, which could contribute to the persistence of symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Kin Israel Notarte et al.
Summary: This systematic review investigates the association between COVID-19 vaccination and long-COVID symptoms. The findings suggest that vaccination is associated with reduced risks of long-COVID, with preliminary evidence showing that two doses are more effective than one dose. The impact of vaccination on people with existing long-COVID symptoms is still controversial.
Article
Biochemistry & Molecular Biology
Douglas B. Kell et al.
BIOCHEMICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Arneaux Kruger et al.
Summary: Post-acute sequelae of COVID-19 (PASC), also known as long COVID, has become a global health and economic burden. The most challenging aspect of this condition is that traditional pathology tests may not detect the presence of insoluble fibrin amyloid microclots and the trapped inflammatory molecules. A study found that long COVID patients have symptoms such as constant fatigue, cognitive impairment, depression, and anxiety. The presence of pro-inflammatory molecules and significant platelet hyperactivation in these patients suggests a failed fibrinolytic system and potential implications for individuals with comorbidities.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Medicine, Legal
Anju Khairwa et al.
Summary: This systematic study aims to evaluate autopsy findings in paediatric cases of COVID-19. The autopsy findings showed variable pathological changes in all important organs of children with COVID-19, which can contribute to a better understanding of the pathogenesis of SARS-CoV-2.
FORENSIC SCIENCE MEDICINE AND PATHOLOGY
(2022)
Article
Medicine, General & Internal
Sarah Wulf Hanson et al.
Summary: This study estimated the proportion and duration of Long COVID symptoms in individuals with symptomatic SARS-CoV-2 infection in 2020 and 2021. The results showed differences in the prevalence and duration of Long COVID symptoms across different age and gender groups.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Infectious Diseases
Marta Bertran et al.
JOURNAL OF INFECTION
(2022)
Article
Immunology
Danilo Buonsenso et al.
Summary: This is the first international study to describe a global reduction in the trend of MIS-C incidence during the COVID-19 pandemic. COVID-19 vaccination and other factors possibly linked to the virus itself and/or community transmission may have played a role in preventing new cases of MIS-C.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Leonardo Di Gennaro et al.
Summary: Emerging data suggests a possible association between endotheliopathy changes and post covid condition (PCC) in adults. This study aimed to investigate the coagulation profiles of children with PCC compared to a control group of recovered children. It was found that children with PCC had a higher proportion of abnormal D-dimer levels.
SCIENTIFIC REPORTS
(2022)
Article
Rehabilitation
Laura A. Malone et al.
Article
Pediatrics
Suchitra Rao et al.
Summary: This retrospective cohort study analyzed the symptoms, health conditions, and medications associated with PASC in children under 21 years old. The study found that myocarditis was the most common PASC-associated condition, and that acute illness severity, young age, and comorbid complex chronic disease increased the risk of PASC.
Article
Biochemistry & Molecular Biology
Vamsi P. Guntur et al.
Summary: Exercise intolerance is a common symptom in patients with post-acute sequelae of severe acute respiratory syndrome coronavirus infection (PASC), also known as long-COVID. This study aimed to determine if the metabolic disturbances observed in acute COVID-19 patients are also present in PASC. The results showed that PASC patients have altered fatty acid metabolism and dysfunctional mitochondrial lipid catabolism, which may contribute to exercise intolerance. These findings provide insights into the metabolic changes associated with PASC and suggest potential therapeutic strategies targeting mitochondrial function.
Article
Pediatrics
Danilo Buonsenso et al.
Summary: This study aimed to characterize and compare long-term post-SARS-CoV-2 infection outcomes in adults and children in a specific region in Italy. The study found that children can experience persistent multisystemic symptoms months after a diagnosis of mild acute SARS-CoV-2 infection, although less frequently and less severely than co-habitant adults. There was no correlation between symptoms experienced by adults and children living in the same household.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Cansu Suskun et al.
Summary: This study compares the intestinal microbiota composition in children diagnosed with MIS-C and acute COVID-19 infection with healthy children. The results show significant changes in the microbiota composition of MIS-C cases, with higher diversity and richness compared to healthy controls, and a higher relative abundance of Bacteroidetes and lower abundance of Firmicutes at the phylum level.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Jonas F. Ludvigsson
Summary: This study focuses on the persistent symptoms in five Swedish children post-COVID-19, indicating a lack of pediatric data on long COVID. Similarly to adults, children may also experience symptoms of long COVID with females potentially being more affected.
Editorial Material
Immunology
Danilo Buonsenso et al.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Letter
Pediatrics
Javier Nogueira Lopez et al.
Article
Pediatrics
Danilo Buonsenso et al.
Article
Pediatrics
Erika Molteni et al.
Summary: Most school-aged children in the UK with SARS-CoV-2 infection are asymptomatic or experience mild illness, with longer duration and higher symptom burden observed in older children. Persistence of illness is more common in older children, but symptom burden does not increase over time and most recover within 56 days. Children who test negative for SARS-CoV-2 may also experience prolonged illness with higher symptom burden.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Editorial Material
Pediatrics
Ellinor Sterky et al.
Article
Cardiac & Cardiovascular Systems
Etheresia Pretorius et al.
Summary: Individuals with Long COVID/PASC may exhibit persistent symptoms due to the presence of persistent circulating plasma microclots that are resistant to fibrinolysis, including fatigue, shortness of breath, sleep issues, and anxiety or depression.
CARDIOVASCULAR DIABETOLOGY
(2021)
Letter
Medicine, General & Internal
Thomas Radtke et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Pediatrics
Caroline L. H. Brackel et al.
Summary: A survey of Dutch pediatricians identified 89 children aged 2-18 suspected of long-COVID, with 36% experiencing severe limitations in daily function. Common symptoms include fatigue, dyspnea, and concentration difficulties. The study emphasizes the need for a multidisciplinary approach to early detection and effective management of this condition in pediatric population.
PEDIATRIC PULMONOLOGY
(2021)
Article
Pediatrics
Ali A. Asadi-Pooya et al.
Summary: The study investigated the prevalence and symptoms of long COVID in children and adolescents in hospitals across Fars province, Iran, from February 19, 2020, to November 20, 2020. A total of 58 patients were included, with 26 (44.8%) experiencing symptoms of long COVID, such as fatigue, shortness of breath, exercise intolerance, weakness, and walking intolerance. Older age, muscle pain on admission, and intensive care unit admission were significantly associated with long COVID.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Microbiology
Jeffrey E. Gold et al.
Summary: The study found a prevalence of 30.3% for long COVID symptoms among COVID-19 patients, with some initially asymptomatic patients developing long-term symptoms. Additionally, a significantly higher rate of EBV reactivation was observed in long COVID subjects compared to control subjects, suggesting a potential association between COVID-19 inflammation and EBV reactivation.
Article
Pediatrics
Danilo Buonsenso et al.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Letter
Pediatrics
Daniela Say et al.
LANCET CHILD & ADOLESCENT HEALTH
(2021)
Letter
Medicine, General & Internal
Angelo Carfi et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Immunology
Jiufeng Sun et al.
EMERGING INFECTIOUS DISEASES
(2020)
