Future regenerative therapies for corneal disease

Purpose of reviewTo highlight the progress and future direction of stem-cell based regenerative therapies for the treatment of corneal diseaseRecent findings Corneal stem cell-based therapies, such as limbal stem cell transplantation, corneal stromal stem cell transplantation, endothelial stem cell transplantation, and stem cell-derived extracellular vesicles have demonstrated promising results in the laboratory. Although most are still in preclinical development or early phase clinical trials, these stem cell-based therapies hold potential to facilitate tissue regeneration, restore native function, and inhibit pathologic disease processes such as fibrosis, inflammation, and neovascularization.Summary Stem cell-based therapy offers a promising therapeutic option that can circumvent several of the challenges and limitations of traditional surgical treatment. This concise review summarizes the progress in stem-cell based therapies for corneal diseases along with their history, underlying mechanisms, limitations, and future areas for development.

Automated summary

This concise review highlights the progress and future direction of stem-cell based regenerative therapies for corneal disease, including promising results of various methods such as stem cell transplantation and extracellular vesicles. While still in preclinical development or early clinical trials, these stem cell-based therapies have the potential to facilitate tissue regeneration, restore native function, and inhibit pathological processes.