Sortilin and hypertension

Purpose of reviewThe current review aims to present the latest scientific updates on the role of Sortilin in the pathophysiology of hypertension.Recent findingsThe main focus of this systematic overview is on the functional contribution of Sortilin to the pathogenesis of hypertension. Sortilin is a glycoprotein mostly known for its actions as a trafficking molecule directing proteins to specific secretory or endocytic compartments of the cell. Emerging evidence indicates that Sortilin is associated with pathological conditions, including inflammation, arteriosclerosis, dyslipidemia, insulin resistance, and vascular calcification. Most recently, Sortilin has been shown to finely control endothelial function and to drive hypertension by modulating sphingolipid/ceramide homeostasis and by triggering oxidative stress.The latest findings linking Sortilin and hypertension that are herein discussed can inspire novel areas of research which could eventually lead to the discovery of new therapeutic strategies in cardiovascular medicine.

Automated summary

The purpose of this review is to provide the latest scientific updates on the role of Sortilin in the pathophysiology of hypertension. The main focus is on the functional contribution of Sortilin to the development of hypertension. Sortilin, known as a glycoprotein, primarily acts as a trafficking molecule directing proteins within the cell. Recent evidence suggests that Sortilin is associated with various pathological conditions, including inflammation, arteriosclerosis, dyslipidemia, insulin resistance, and vascular calcification. It has also been found that Sortilin plays a crucial role in controlling endothelial function and triggering hypertension through sphingolipid/ceramide homeostasis and oxidative stress.