New targets for antimalarial drug discovery

Phenotypic screening methods have placed numerous preclinical candidates into the antimalarial drug-discovery pipeline. As more chemically validated targets become available, efforts are shifting to target-based drug discovery. Here, we briefly review some of the most attractive targets that have been identified in recent years.

Automated summary

Phenotypic screening methods have been instrumental in identifying potential antimalarial drug candidates, but recent efforts are focused on target-based drug discovery.