Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 71, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2022.102222
Keywords
Fluorescent Sterols; Sterol transport; Bioimaging with sterols; Photo- click analogues; Extrinsic fluorophores
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Funding
- SERB
- IIT Gandhinagar
- [CRG/2018/004020]
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This review focuses on recent literature published between 2020 and 2022, with particular emphasis on the use of extrinsic fluorophores to study sterol-driven biological processes, including sterol transport, biomolecular interactions, and biological imaging.
Sterols play a significant role in many physiological processes affecting membrane organization, transport, permeability, and signal transduction. The development of fluorescent sterol analogs that have immediate functional relevance to the nat-ural biomolecules is one approach to understanding the sterol -driven physiological processes. Visualizing cellular compart-ments with tailor-made fluorescent molecules through specific labeling methods enables organelle targeting and reveals dy-namic information. In this review, we focus on the recent literature published between 2020 and 2022, with particular emphasis on extrinsic fluorophores and their investigations of sterol-driven biological processes involving sterol transport, biomolecular interactions, and biological imaging.
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