Journal
CURRENT OPINION IN BIOTECHNOLOGY
Volume 78, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2022.102837
Keywords
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Funding
- National Science Foundation (NSF) Expeditions [1521925]
- NSF RoL Award [1840257]
- NSFGraduate Research Fellowships Program
- Ford Foundation Predoctoral Fellowship
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1521925] Funding Source: National Science Foundation
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This review discusses the progression of control systems design in synthetic biology, from understanding the function of naturally occurring regulatory motifs to creating genetic circuits with sufficiently robust function for biotechnology applications.
Natural biological systems display complex regulation and synthetic biomolecular systems have been used to understand their natural counterparts and to parse sophisticated regulations into core design principles. At the same time, the engineering of biomolecular systems has unarguable potential to transform current and to enable new, yet-to-be-imagined, biotechnology applications. In this review, we discuss the progression of control systems design in synthetic biology, from the purpose of understanding the function of naturally occurring regulatory motifs to that of creating genetic circuits whose function is sufficiently robust for biotechnology applications.
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