Hydrogen Sulfide (H2S): As a Potent Modulator and Therapeutic Prodrug in Cancer

Article Chemistry, Multidisciplinary

ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway

Fang-fang Cai et al.

Summary: The study demonstrated that ADT-OH inhibits the EMT process in melanoma cells and their proliferation, exerting anti-metastatic effects.

ACTA PHARMACOLOGICA SINICA (2022)

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Article Cell Biology

Extracellular cysteines C226 and C232 mediate hydrogen sulfide-dependent inhibition of Orai3-mediated store-operated calcium entry

Adriana M. Fresquez et al.

Summary: The gaseous signaling molecule hydrogen sulfide (H2S) selectively modifies Orai3 by regulating the cysteines 226 and 232 residues, which limits the occurrence of store-operated calcium entry (SOCE).

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Hydrogen Sulfide and the Kidney: Physiological Roles, Contribution to Pathophysiology, and Therapeutic Potential

Maria Peleli et al.

Summary: Hydrogen sulfide plays crucial roles in the kidney by exerting antioxidant, cytoprotective, vasodilatory effects, among others, impacting renal function and diseases significantly. Lower H2S levels are associated with various renal pathologies, highlighting the importance of uncovering its molecular targets for potential therapeutic interventions in renal diseases. Further studies on H2S in the kidney, including mapping expression patterns of related enzymes and generating cell-specific knockout models, will provide valuable insights for developing novel, more effective strategies for treating renal diseases.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Article Oncology

Overexpression of CBS/H2S inhibits proliferation and metastasis of colon cancer cells through downregulation of CD44

Yuyang Zhang et al.

Summary: This study found that overexpression of CBS and exogenous provision of H2S can inhibit the proliferation and migration of colon cancer cells, and CD44 and the transcription factor SP-1 may be involved.

CANCER CELL INTERNATIONAL (2022)

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Article Pharmacology & Pharmacy

Targeting Mitochondrial Large-Conductance Calcium-Activated Potassium Channel by Hydrogen Sulfide via Heme-Binding Site

Agnieszka Walewska et al.

Summary: This study demonstrates the importance of mitochondrial channels like mitoBK(ca) in cytoprotection during ischemia/reperfusion. Heroin can potentially inhibit mitoBK(ca) activity. Hydrogen sulfide activates hemin-inhibited mitoBK(ca) by binding to heroin iron. The hydrogen sulfide effect is mimicked by imidazole, likely through a similar mechanism.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2022)

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Article Biochemistry & Molecular Biology

Effects of Hydrogen Sulfide on the Microbiome: From Toxicity to Therapy

Andre G. Buret et al.

Summary: This article reviews the interaction between hydrogen sulfide (H2S), gut microbiota, and health, highlighting the toxic or therapeutic effects of H2S depending on its concentration and source. Low levels of H2S directly stabilize mucus layers, prevent microbiota biofilm fragmentation, and help resolve inflammation and tissue injury. Additionally, dietary H2S may also modulate the abundance and function of microbiota.

ANTIOXIDANTS & REDOX SIGNALING (2022)

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Article Multidisciplinary Sciences

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Cyril Statzer et al.

Summary: Inhibition of mTORC1 or translation increases ATF-4 expression independently of ISR signaling in C. elegans. ATF-4 promotes longevity by increasing hydrogen sulfide production through the enzyme CTH-2.

NATURE COMMUNICATIONS (2022)

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Article Materials Science, Biomaterials

Thioredoxin reductase-triggered fluorogenic donor of hydrogen sulfide: a model study with a symmetrical organopolysulfide probe with turn-on near-infrared fluorescent emission

Sulendar K. Mahato et al.

Summary: This article describes the rational development of an organopolysulfide-based fluorogenic donor of hydrogen sulfide (H2S) that can be activated by the antioxidant selenoenzyme thioredoxin reductase (TrxR) to release a near-infrared (NIR) fluorophore. The study found that the probes showed higher reactivity towards DTT, a marker of TrxR activity, compared to the well-known cellular antioxidant GSH. The results suggest the potential biomedical applications of this system in H2S-mediated therapeutics.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Article Pharmacology & Pharmacy

Protective Effects of Allicin on Acute Myocardial Infarction in Rats via Hydrogen Sulfide-mediated Regulation of Coronary Arterial Vasomotor Function and Myocardial Calcium Transport

Tianwei Cui et al.

Summary: Allicin has protective effects on acute myocardial infarction by inducing H2S production, resulting in effective coronary artery dilation and regulation of Ca2+ homeostasis.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Cell Biology

Buffering Adaptive Immunity by Hydrogen Sulfide

Giulia Pozzi et al.

Summary: T cell-mediated adaptive immunity responds to non-self antigens and pathogens by activating and proliferating various T cell populations, with hydrogen sulfide playing a crucial regulatory role in this process.

CELLS (2022)

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Review Biochemistry & Molecular Biology

The Pathophysiology of H2S in Renal Glomerular Diseases

Karl-Friedrich Beck et al.

Summary: This article discusses the synthesis and action of hydrogen sulfide (H2S) in glomerular cells, as well as its protective effects on the glomerulus. It also highlights the interaction between H2S and other gasotransmitters.

BIOMOLECULES (2022)

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Article Pharmacology & Pharmacy

Slow sulfide donor GYY4137 potentiates effect of paclitaxel on colorectal carcinoma cells

Marek Kajsik et al.

Summary: The study demonstrated that the sensitivity of colorectal carcinoma cell lines to paclitaxel (PTX) could be increased by using the slow sulfide donor GYY4137, probably through potentiation of apoptosis.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

The Protective Effects of Hydrogen Sulfide New Donor Methyl S-(4-Fluorobenzyl)-N-(3,4,5-Trimethoxybenzoyl)-l-Cysteinate on the Ischemic Stroke

Jing Fan et al.

Summary: In this paper, the design, synthesis, and biological evaluation of a novel compound MTC were reported. The results showed that MTC had protective effects on ischemia-reperfusion-induced neuronal injury, possibly through modulation of multiple signaling pathways and protein levels.

MOLECULES (2022)

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Article Physiology

The effect of hydrogen sulfide on the contractility of cerebral arterioles. A pilot study

Eleni Dongo et al.

Summary: This study investigated the effect of hydrogen sulfide on cerebral arteriolar tone and its mechanism. The results showed that endogenously produced hydrogen sulfide is a moderate vasoconstrictor in these important vessels. Hydrogen sulfide exhibits a biphasic effect, with low concentrations causing moderate vasoconstriction and higher concentrations leading to initial contraction followed by dilation. The vasodilation effect is prevented by inhibition of the Cl-/HCO3- exchanger.

PHYSIOLOGY INTERNATIONAL (2022)

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Article Medicine, General & Internal

Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation

Diane Macabrey et al.

Summary: Intimal hyperplasia (IH) is a major limitation in the long-term success of revascularization. This study investigated the use of sodium thiosulfate (STS) as a potential treatment to limit IH. The findings showed that STS inhibited IH in mice and human vein segments, as well as inhibited cell proliferation and promoted microtubule depolymerization. This suggests that STS acts as an H2S donor to limit vascular smooth muscle cell migration and proliferation.

EBIOMEDICINE (2022)

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Article Spectroscopy

Construction of novel coumarin-carbazole-based fluorescent probe for tracking of endogenous and exogenous H2S in vivo with yellow-emission and large Stokes shift

Xu Tong et al.

Summary: Recent studies have shown that H2S, an endogenous gas-messenger, plays an important role in physiological processes and its abnormal levels can lead to serious diseases. In this work, a novel fluorescent probe COZ-DNB was developed for detecting H2S with high sensitivity, stability, and selectivity. The probe was applied successfully in imaging exogenous and endogenous H2S in living cells and zebrafish. This research provides a potential tool for investigating the biological functions of H2S in pathological processes.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Analytical

A nitrobenzoxadiazole-based near-infrared fluorescent probe for the specific imaging of H2S in inflammatory and tumor mice

Wen-Xin Wang et al.

Summary: A novel NBD-based near-infrared (NIR) fluorescent probe CX-N with high selectivity for detecting H2S has been synthesized in this study. With significant increase in NIR fluorescence and fast response after reaction with H2S, CX-N can be used for H2S imaging in live cells and animals, as well as real-time imaging in inflammatory and tumor mice.

ANALYST (2022)

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Review Multidisciplinary Sciences

Emerging analytical tools for the detection of the third gasotransmitter H2S, a comprehensive review

Hany Ibrahim et al.

Summary: This article focuses on several analytical technologies used to determine H2S, including spectroscopic, chromatographic, and electrochemical methods. The advantages and limitations of each technique are highlighted, with special emphasis on their application for in vivo measurement of H2S (e.g., biofluids and tissues).

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Multidisciplinary Sciences

Hydrogen sulfide and vascular regulation - An update

Boyang Lv et al.

Summary: This review summarizes the function of hydrogen sulfide (H2S) in vascular physiology and pathophysiology, including its role in regulating vascular tone, proliferation, apoptosis, and autophagy of vascular cells. The downregulation of H2S pathway is implicated in various vascular diseases, while H2S supplementation shows promise in preventing disease progression by regulating vascular tone, inhibiting inflammation, and protecting against oxidative stress. Additional research is needed to further understand the role of H2S in vascular physiology and pathophysiology.

JOURNAL OF ADVANCED RESEARCH (2021)

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Article Multidisciplinary Sciences

Targeting hydrogen sulphide signaling in breast cancer

Rana Ahmed Youness et al.

Summary: Hydrogen sulphide (H2S) plays a significant role in the pathogenesis of breast cancer, and targeting H2S can mitigate the disease. Knockdown of H2S-synthesizing enzymes in specific types of breast cancer cells resulted in reduced malignancy and increased susceptibility to cytotoxic activity of immune cells. Computational analysis revealed H2S signaling pathways in different breast cancer cell lines and identified a potential upstream regulator that could synergistically abrogate cancer cell malignancy.

JOURNAL OF ADVANCED RESEARCH (2021)

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Review Geriatrics & Gerontology

Reproductive Longevity and Aging: Geroscience Approaches to Maintain Long-Term Ovarian Fitness

Natalia Llarena et al.

Summary: As delayed childbearing becomes more prevalent worldwide, understanding the biological basis and implications of age-related infertility has become increasingly important. Women aged 35 and older face significantly higher incidences of infertility, aneuploidy, and birth defects due to age-related declines in ovarian reserve and oocyte quality. Various pathways related to aging and nutrient-sensing in the mammalian ovary regulate primordial follicle maintenance and follicular growth, ultimately impacting reproductive longevity.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Multidisciplinary Sciences

Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation

Daniel Giovinazzo et al.

Summary: Alzheimer's disease is characterized by memory, executive, and motor function deterioration, with neuropathological hallmarks including neurofibrillary tangles, paired helical filaments, and amyloid plaques. Dysregulation of signaling by hydrogen sulfide has been shown during aging and may play a role in preventing hyperphosphorylation of Tau in Alzheimer's disease. Furthermore, administering the H2S donor sodium GYY4137 to mouse models of Alzheimer's disease has been shown to ameliorate motor and cognitive deficits associated with the disease.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Biochemistry & Molecular Biology

Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Bindu D. Paul et al.

Summary: Hydrogen sulfide (H2S) was once thought to be only toxic, but is now known to also act as an endogenous signaling molecule. The effects of H2S on cellular physiology are dose-dependent, with lower concentrations being beneficial and higher concentrations being cytotoxic. In particular, H2S has contrasting effects on mitochondrial function, inhibiting the electron transport chain at higher concentrations and stimulating bioenergetics at lower concentrations.

REDOX BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide and DNA repair

Rodney Shackelford et al.

Summary: Recent evidence has shown that H2S plays a crucial role in the DNA damage response (DDR) and maintenance of genomic stability, affecting cell cycle checkpoints, DNA synthesis, and expression of various proteins. Both H2S donors and synthesis inhibitors can modulate cellular processes related to DDR, suggesting implications for cancer chemotherapy and metabolic pathways involving H2S.

REDOX BIOLOGY (2021)

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Review Cell Biology

Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells

Csaba Szabo

Summary: H2S, previously known as a toxic gas and environmental hazard, has been found to play multiple biological regulatory roles in mammalian cells as an endogenously produced gaseous transmitter. Its effects in mitochondria serve as an electron transport stimulator in physiological concentrations, particularly significant in cancer cells where it helps maintain mitochondrial organization and DNA repair.

CELLS (2021)

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Article Multidisciplinary Sciences

In vitro anticancer activity of hydrogen sulfide and nitric oxide alongside nickel nanoparticle and novel mutations in their genes in CRC patients

Zjwan Housein et al.

Summary: This study assessed the impact of nickel nanoparticles and scorpion venom on colorectal cancer cells, as well as the influence of 5-FU, H2S, and NO, revealing that H2S enhances the anticancer efficiency of 5-FU in the presence of NiNPs, while NO exhibits antiapoptotic activity in CRC cell lines.

SCIENTIFIC REPORTS (2021)

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Review Biochemistry & Molecular Biology

Trends in H2S-Donors Chemistry and Their Effects in Cardiovascular Diseases

Angela Corvino et al.

Summary: Hydrogen sulfide (H2S) is an endogenous gasotransmitter that has emerged as an important regulatory mediator in numerous human cell functions. It plays a significant role in various physio-pathological processes and the protective effects of H2S donors have been extensively studied in different disease models. The growing interest in H2S-releasing compounds highlights their potential as promising drugs for the treatment of cardiovascular diseases.

ANTIOXIDANTS (2021)

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Review Pharmacology & Pharmacy

An Updated Insight Into Molecular Mechanism of Hydrogen Sulfide in Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury Under Diabetes

Hai-Jian Sun et al.

Summary: Cardiovascular diseases are common complications of diabetes, with diabetic cardiomyopathy being a major cause of death in diabetes. Research has found that hydrogen sulfide plays a critical role in diabetic cardiomyopathy and has protective effects in conditions such as myocardial infarction and heart failure under diabetic conditions. Studies have identified multiple molecular mechanisms responsible for H2S's protective effects against diabetes-induced cardiac injury.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

Roles of H2S and NO in regulating the antioxidant system of Vibrio alginolyticus under norfloxacin stress

Shuhe Chen et al.

Summary: The antioxidant system of Vibrio alginolyticus was found to be respectively enhanced by the gas molecules of H2S and NO under the stress induced by norfloxacin, suggesting a potential crosstalk regulative mechanism between H2S and NO. These results lay the foundation for the research on the regulation network of H2S and NO and provide insights for the future synthesis of anti-vibrio drugs.

PEERJ (2021)

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Article Biochemistry & Molecular Biology

Cystathionine gamma-lyase/H2S signaling facilitates myogenesis under aging and injury condition

Yanjie Zhang et al.

Summary: Hydrogen sulfide (H2S) plays a crucial role in maintaining myogenesis and may serve as a potential candidate for preventing age-related sarcopenia and treating muscle injury.

FASEB JOURNAL (2021)

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Review Oncology

Therapeutic potential of endogenous hydrogen sulfide inhibition in breast cancer

Ming Li et al.

Summary: Hydrogen sulfide plays a crucial role in regulating various physiological and pathological processes, including its involvement in promoting oncogenesis in breast cancer. Inhibiting H2S-producing enzymes could be a potential therapeutic strategy for controlling the growth and metastasis of breast cancer.

ONCOLOGY REPORTS (2021)

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Article Multidisciplinary Sciences

Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent manner

Nazmin Bithi et al.

Summary: The study investigates the impact of dietary restriction (DR) on protein persulfidation, finding enrichment of persulfidation in liver, kidney, muscle, and brain, but decreased levels in the heart. Mice lacking cystathionine gamma-lyase (CGL) show an overall decrease in tissue protein persulfidation numbers under DR.

NATURE COMMUNICATIONS (2021)

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Review Allergy

Hydrogen sulfide as a novel biomarker of asthma and chronic obstructive pulmonary disease

Yasuhito Suzuki et al.

Summary: Hydrogen sulfide (H2S) is recognized as the third important gas-signaling molecule, with dual effects of anti-inflammatory and antioxidant properties, but potentially pro-inflammatory under certain conditions. In respiratory disorders, H2S has shown promise as a novel biomarker for predicting asthma risks and identifying inflammatory phenotypes for personalized treatment.

ALLERGOLOGY INTERNATIONAL (2021)

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Review Biochemistry & Molecular Biology

The Role of Hydrogen Sulfide in Respiratory Diseases

Saadullah Khattak et al.

Summary: Hydrogen sulfide has been widely investigated for its therapeutic potential in respiratory diseases such as obstructive respiratory disease and bronchial asthma. Despite extensive research, a concrete literature review is crucial for future therapeutics. This review provides a comprehensive overview of the effective role of H2S in respiratory diseases and its metabolism processes in the lung.

BIOMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide as a Potential Therapy for Heart Failure-Past, Present, and Future

Kyle B. LaPenna et al.

Summary: Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays a critical role in cardiac and vascular biology by regulating vascular tone, oxidant defenses, and exerting cytoprotective effects. Recent studies have shown that H2S modulates various components of metabolic syndrome and exhibits cardioprotective signaling in heart failure.

ANTIOXIDANTS (2021)

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Article Gastroenterology & Hepatology

The Sulfur Microbial Diet Is Associated With Increased Risk of Early-Onset Colorectal Cancer Precursors

Long H. Nguyen et al.

Summary: The study found that in a cohort of young women, dietary interactions with gut sulfur-metabolizing bacteria may play a role in early-onset colorectal carcinogenesis, possibly beginning in adolescence.

GASTROENTEROLOGY (2021)

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Review Biochemistry & Molecular Biology

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

Rong-Hsuan Wang et al.

Summary: Hydrogen sulfide, while important for physiological functions, is also associated with aberrant expression in cancer development; understanding the roles of tumor-derived H2S in cancer provides opportunities for targeted therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Hydrogen Sulfide Reduces Ischemia and Reperfusion Injury in Neuronal Cells in a Dose- and Time-Dependent Manner

Stefanie Scheid et al.

Summary: Experimental results confirm that inhaled H2S at appropriate concentrations can exert neuroprotective effects in rat retinal ischemia-reperfusion injury, reducing cell apoptosis and inflammation. H2S treatment modulates NF-kappa B activation and is expected to alleviate inflammation after retinal injury.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth

Ethan Read et al.

Summary: Disulfiram and hydrogen sulfide can sensitize liver cancer cells by inhibiting ALDH activity, and H2S can also inhibit the adhesion of liver cancer stem cells. The combination of DSF and H2S shows potential in inhibiting cancer cell growth and tumor development by targeting ALDH.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Efficacy of Novel Aminooxyacetic Acid Prodrugs in Colon Cancer Models: Towards Clinical Translation of the Cystathionine β-Synthase Inhibition Concept

Mark R. Hellmich et al.

Summary: The upregulation of CBS in cancer cells has been identified as a tumor-promoting factor, leading to the synthesis of a novel CBS-targeting prodrug YD0251 with higher efficacy in inhibiting tumor growth compared to the prototypical CBS inhibitor AOAA. The prodrug was successful in suppressing tumor growth in vivo with low toxicity, and a potential plasma marker for CBS-expressing tumors was identified for potential future theranostic applications to match CBS inhibitor therapy with high-CBS expressors.

BIOMOLECULES (2021)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide (H2S) and Polysulfide (H2Sn) Signaling: The First 25 Years

Hideo Kimura

Summary: Initially considered a toxic gas, further research has shown that H2S has physiological roles and can act as a signaling molecule, working in synergy with NO to relax vascular smooth muscle. H2Sn, produced by 3MST, regulate the activity of ion channels and enzymes, and even affect tumor growth.

BIOMOLECULES (2021)

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Article Medicine, Research & Experimental

Severe consequences of a high-lipid diet include hydrogen sulfide dysfunction and enhanced aggression in glioblastoma

Daniel J. Silver et al.

Summary: Research shows that consuming a high-fat diet may worsen glioblastoma (GBM), mainly by inhibiting the production of hydrogen sulfide (H2S) and increasing the enrichment of cancer stem cells (CSC). Increasing the bioavailability of H2S may help suppress the development of GBM.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Cell Biology

Hydrogen Sulfide Upregulates Acid-sensing Ion Channels via the MAPK-Erk1/2 Signaling Pathway

Zhong Peng et al.

Summary: The study demonstrates that H2S can regulate both the expression and function of ASICs, potentially through the MAPK signaling pathway. This regulation may involve roles in learning and memory, protection during seizure activity, and modulation of nociception.

FUNCTION (2021)

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Article Chemistry, Multidisciplinary

A phase-transfer catalyst-based nanoreactor for accelerated hydrogen sulfide bio-imaging

Panfei Xing et al.

Summary: By using a phase-transfer catalyst approach to conjugate fluorescent probes with amphiphilic polymers, H2S nanoprobes can be assembled in an aqueous solution, resulting in significantly reduced detection time.

NANOSCALE (2021)

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Article Medicine, General & Internal

Novel H2S donor proglumide-ADT-OH protects HUVECs from ox-LDL-induced injury through NF-KB and JAK/SATA pathway

Xuelan Ou et al.

Summary: The synthesized H2S donor P-A has a protective effect on HUVEC injured by ox-LDL, and the protective mechanism mainly involves the regulation of the JAK/STAT pathway and NF-KB pathway.

OPEN MEDICINE (2021)

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Review Pathology

Molecular Functions of Hydrogen Sulfide in Cancer

Rodney E. Shackelford et al.

Summary: Hydrogen sulfide plays a complex role in various human malignancies, promoting multiple cancer-related processes and impacting prognosis. Investigating the function of H2S in cancer is crucial for understanding its molecular mechanisms and intervening in cancer development.

PATHOPHYSIOLOGY (2021)

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Article Materials Science, Biomaterials

Enhanced NO-induced angiogenesis via NO/H2S co-delivery from self-assembled nanoparticles

Jieun Lee et al.

Summary: The co-release of NO and H2S in nanoparticles can accelerate angiogenesis and demonstrate high biocompatibility and sustained releasing behavior in various cell types.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

Kuljeet Kaur et al.

Summary: A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics was reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

CHEMICAL COMMUNICATIONS (2021)

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Review Biotechnology & Applied Microbiology

The roles of microbial products in the development of colorectal cancer: a review

Yongkun Fang et al.

Summary: A large number of microbes in the gut play a role in processing ingested food, and their products are implicated in the development of colorectal cancer. The molecular mechanisms linking gut microbial products to CRC are not fully understood, with some products having controversial roles in CRC. Investigating the effects of gut microbiota products on CRC and their mechanisms is crucial for prevention and treatment.

BIOENGINEERED (2021)

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Review Biochemistry & Molecular Biology

Role of hydrogen sulfide donors in cancer development and progression

Ebenezeri Erasto Ngowi et al.

Summary: There are numerous potential cancer therapeutic targets emerging recently, with hydrogen sulfide playing a role in regulating cellular activities. However, the outcome of treating cancer cells with H2S donors depends on multiple factors. Various signaling pathways have been reported to be altered following treatments with H2S donors, suggesting their potential in cancer treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Biological Effects of Morpholin-4-Ium 4 Methoxyphenyl (Morpholino) Phosphinodithioate and Other Phosphorothioate-Based Hydrogen Sulfide Donors

Dawn Sijin Nin et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Biochemistry & Molecular Biology

Enhanced Analgesic Effects and Gastrointestinal Safety of a Novel, Hydrogen Sulfide-Releasing Anti-Inflammatory Drug (ATB-352): A Role for Endogenous Cannabinoids

Soraia K. P. F. Costa et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

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Article Pharmacology & Pharmacy

Hydrogen sulfide modulates epithelial-mesenchymal transition and angiogenesis in non-small cell lung cancer via HIF-1 alpha activation

Mingqi Wang et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

NOSH-aspirin (NBS-1120) inhibits pancreatic cancer cell growth in a xenograft mouse model: Modulation of FoxM1, p53, NF-κB, iNOS, caspase-3 and ROS

Mitali Chattopadhyay et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Dermatology

Exogenous hydrogen sulfide inhibits human melanoma cell development via suppression of the PI3K/AKT/ mTOR pathway

Qing Xiao et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2020)

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Article Cell Biology

ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD

Fangfang Cai et al.

CELL DEATH & DISEASE (2020)

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Article Multidisciplinary Sciences

H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

Luyan Wu et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Analytical

Magnetic-Photoacoustic Dual-Mode Probe for the Visualization of H2S in Colorectal Cancer

Chenglin Yan et al.

ANALYTICAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

Nitric Oxide and Hydrogen Sulfide: A Nice Pair in the Respiratory System

Salvatore Fuschillo et al.

CURRENT MEDICINAL CHEMISTRY (2020)

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Review Biochemistry & Molecular Biology

The chemical biology of hydrogen sulfide and related hydropersulfides: interactions with biologically relevant metals and metalloproteins

Jon M. Fukuto et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide

Hai-Jian Sun et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Cell Biology

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs

Agapios Sachinidis

CELLS (2020)

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Editorial Material Biochemistry & Molecular Biology

H2S, Polysulfides, and Enzymes: Physiological and Pathological Aspects

Noriyuki Nagahara et al.

BIOMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Cystathionine-beta-synthase: Molecular Regulation and Pharmacological Inhibition

Karim Zuhra et al.

BIOMOLECULES (2020)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide and its donors: Novel antitumor and antimetastatic therapies for triple-negative breast cancer

Haonan Li et al.

REDOX BIOLOGY (2020)

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Review Pharmacology & Pharmacy

Hydrogen sulfide signalling in the CNS - Comparison with NO

Hideo Kimura

BRITISH JOURNAL OF PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

Hydrogen sulfide: An endogenous regulator of the immune system

Nahzli Dilek et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Endocrinology & Metabolism

Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis

Qian-Rong Qi et al.

ENDOCRINOLOGY (2020)

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Article Cell Biology

Diabetic nephropathy associates with deregulation of enzymes involved in kidney sulphur metabolism

Elena Uyy et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Ophthalmology

Hydrogen Sulfide: A Potential Therapeutic Target in the Development of Diabetic Retinopathy

Ghulam Mohammad et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2020)

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Review Cardiac & Cardiovascular Systems

Advances in the Protective Mechanism of NO, H2S, and H2 in Myocardial Ischemic Injury

Wei-lu Wang et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

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Article Oncology

Hydrogen Sulfide-Evoked Intracellular Ca2+ Signals in Primary Cultures of Metastatic Colorectal Cancer Cells

Pawan Faris et al.

CANCERS (2020)

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Article Oncology

Diallyl Trisulfide Inhibits Leptin-induced Oncogenic Signaling in Human Breast Cancer Cells but Fails to Prevent Chemically-induced Luminal-type Cancer in Rats

Su-Hyeong Kim et al.

JOURNAL OF CANCER PREVENTION (2020)

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Review Biochemistry & Molecular Biology

A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

Xu Cao et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

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Article Biochemistry & Molecular Biology

The endogenous hydrogen sulfide generating system regulates ovulation

Anthony Estienne et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Review Nutrition & Dietetics

Immunomodulatory Effects of Glutathione, Garlic Derivatives, and Hydrogen Sulfide

Camila Rodrigues et al.

NUTRIENTS (2019)

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Review Cell & Tissue Engineering

Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Jing Jia et al.

CURRENT STEM CELL RESEARCH & THERAPY (2019)

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Article Biochemistry & Molecular Biology

Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells

Adam Y. Xiao et al.

REDOX BIOLOGY (2019)

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Article Chemistry, Multidisciplinary

Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain

Hui Dong et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Oncology

A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways

Qian Dong et al.

CANCER LETTERS (2019)

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Article Biochemistry & Molecular Biology

Signaling by hydrogen sulfide (H2S) and polysulfides (H2Sn) in the central nervous system

Hideo Kimura

NEUROCHEMISTRY INTERNATIONAL (2019)

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Article Biochemistry & Molecular Biology

Sodium/calcium exchanger is involved in apoptosis induced by H2S in tumor cells through decreased levels of intracellular pH

Ivan Szadvari et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2019)

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Article Biotechnology & Applied Microbiology

Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition

Longzheng Xia et al.

ONCOTARGETS AND THERAPY (2019)

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Article Biochemistry & Molecular Biology

Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis

Yi-Hsiang Wang et al.

EMBO REPORTS (2019)

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Article Chemistry, Multidisciplinary

Surface Plasmon Resonance-Enhanced Photoacoustic Imaging and Photothermal Therapy of Endogenous H2S-Triggered Au@Cu2O

Cheng Tao et al.

SMALL (2019)

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Article Chemistry, Multidisciplinary

Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release

Ben Shi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Engineering, Biomedical

Construct of MoSe2/Bi2Se3 nanoheterostructure: Multimodal CT/PT imaging-guided PTT/PDT/chemotherapy for cancer treating

Ying Wang et al.

BIOMATERIALS (2019)

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Article Biochemical Research Methods

First Examples of H2S-Releasing Glycoconjugates: Stereoselective Synthesis and Anticancer Activities

Serena Fortunato et al.

BIOCONJUGATE CHEMISTRY (2019)

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Article Cell Biology

Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice

Yue Wu et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Article Multidisciplinary Sciences

Rapid measurement of hydrogen sulphide in human blood plasma using a microfluidic method

R. Karunya et al.

SCIENTIFIC REPORTS (2019)

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Article Chemistry, Multidisciplinary

Fluorogenic hydrogen sulfide (H2S) donors based on sulfenyl thiocarbonates enable H2S tracking and quantification

Yu Zhao et al.

CHEMICAL SCIENCE (2019)

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Review Medicine, General & Internal

Potential for therapeutic use of hydrogen sulfide in oxidative stress-induced neurodegenerative diseases

Rubaiya Tabassum et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2019)

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Article Multidisciplinary Sciences

Hydrogen sulfide donor GYY4137 suppresses proliferation of human colorectal cancer Caco-2 cells by inducing both cell cycle arrest and cell death

Satoru Sakuma et al.

HELIYON (2019)

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Article Biology

Non-enzymatic hydrogen sulfide production from cysteine in blood is catalyzed by iron and vitamin B6

Jie Yang et al.

COMMUNICATIONS BIOLOGY (2019)

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Article Physiology

Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

Saranya Rajendran et al.

COMPREHENSIVE PHYSIOLOGY (2019)

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Article Chemistry, Analytical

A red mitochondria-targeted AIEgen for visualizing H2S in living cells and tumours

Yufan Ma et al.

ANALYST (2019)

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Review Biochemistry & Molecular Biology

The mechanism of action and role of hydrogen sulfide in the control of vascular tone

Eleni Dongo et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

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Review Pharmacology & Pharmacy

A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications

Chadwick R. Powell et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Review Pharmacology & Pharmacy

The dichotomous role of H2S in cancer cell biology? Deja all over again

Khosrow Kashfi

BIOCHEMICAL PHARMACOLOGY (2018)

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Review Pharmacology & Pharmacy

A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

Csaba Szabo

BIOCHEMICAL PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Role of endogenous and exogenous nitric oxide, carbon monoxide and hydrogen sulfide in HCT116 colon cancer cell proliferation

Gabor Olah et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Article Engineering, Biomedical

Assessment of in vivo degradation profiles of hyaluronic acid hydrogels using temporal evolution of chemical exchange saturation transfer (CEST) MRI

Mohammed Salman Shazeeb et al.

BIOMATERIALS (2018)

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Article Oncology

Endogenous H2S producing enzymes are involved in apoptosis induction in clear cell renal cell carcinoma

Jan Breza et al.

BMC CANCER (2018)

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Review Pharmacology & Pharmacy

Hydrogen sulfide pathway and skeletal muscle: an introductory review

Valentina Vellecco et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

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Article Chemistry, Medicinal

Urea derivative catalyzed enantioselective aldol reaction of isatins with ketones

Li Ming Wang et al.

CHIRALITY (2018)

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Review Neurosciences

Hydrogen Sulfide in Physiological and Pathological Mechanisms in Brain

Mohit Kumar et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)

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Article Oncology

Diallyl Disulfide Inhibits Breast Cancer Stem Cell Progression and Glucose Metabolism by Targeting CD44/PKM2/AMPK Signaling

Xinhua Xie et al.

CURRENT CANCER DRUG TARGETS (2018)

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Review Biochemistry & Molecular Biology

The Role of Hydrogen Sulfide and H2S-donors in Myocardial Protection Against Ischemia/Reperfusion Injury

Valentina Citi et al.

CURRENT MEDICINAL CHEMISTRY (2018)

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Article Biochemistry & Molecular Biology

Cystathionine -synthase regulates mitochondrial morphogenesis in ovarian cancer

Prabir Kumar Chakraborty et al.

FASEB JOURNAL (2018)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins

Chien-Ning Hsu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Oncology

Anticancer effect of exogenous hydrogen sulfide in cisplatin-resistant A549/DDP cells

Ying Ma et al.

ONCOLOGY REPORTS (2018)

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Article Cell Biology

Hydrogen Sulfide Attenuates LPS-Induced Acute Kidney Injury by Inhibiting Inflammation and Oxidative Stress

Yuhong Chen et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Cell Biology

Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System

Ulfuara Shefa et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Protective Mechanism of Hydrogen Sulfide against Chemotherapy-Induced Cardiotoxicity

Shuxu Du et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

A novel role of sONE/NOS3/NO signaling cascade in mediating hydrogen sulphide bilateral effects on triple negative breast cancer progression

Rana Ahmed Youness et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2018)

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Hydrogen Sulfide Signaling in Plants: Emerging Roles of Protein Persulfidation

Angeles Aroca et al.

FRONTIERS IN PLANT SCIENCE (2018)

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The biologic effect of hydrogen sulfide and its function in various diseases

Qing Xiao et al.

MEDICINE (2018)

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Review Chemistry, Multidisciplinary

Chemical Biology of H2S Signaling through Persulfidation

Milos R. Filipovic et al.

CHEMICAL REVIEWS (2018)

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Cardiotoxicity of Anticancer Therapeutics

Jerry Dong et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

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Review Biochemistry & Molecular Biology

H2S biosynthesis and catabolism: new insights from molecular studies

Peter Rose et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

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Review Pharmacology & Pharmacy

Hydrogen Sulfide and T-Type Ca2+ Channels in Pain Processing, Neuronal Differentiation and Neuroendocrine Secretion

Kazuki Fukami et al.

PHARMACOLOGY (2017)

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Review Biochemistry & Molecular Biology

H2S-Mediated Protein S-Sulfhydration: A Prediction for Its Formation and Regulation

Youngjun Ju et al.

MOLECULES (2017)

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Article Oncology

Cystathionine- γ-lyase promotes process of breast cancer in association with STAT3 signaling pathway

Jing You et al.

ONCOTARGET (2017)

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Recent progress and development on polymeric nanomaterials for photothermal therapy: a brief overview

Yingge Shi et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Article Pharmacology & Pharmacy

Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

Zheng-Wei Lee et al.

FRONTIERS IN PHARMACOLOGY (2017)

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Article Multidisciplinary Sciences

New method for quantification of gasotransmitter hydrogen sulfide in biological matrices by LC-MS/MS

Bo Tan et al.

SCIENTIFIC REPORTS (2017)

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Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways

Dongdong Wu et al.

SCIENTIFIC REPORTS (2017)

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Article Cell Biology

Hydrogen sulfide, an enhancer of vascular nitric oxide signaling: mechanisms and implications

Csaba Szabo

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2017)

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Article Cell Biology

Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling

Qingxia Tao et al.

CELL AND TISSUE RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Beyond a Gasotransmitter: Hydrogen Sulfide and Polysulfide in Cardiovascular Health and Immune Response

Shuai Yuan et al.

ANTIOXIDANTS & REDOX SIGNALING (2017)

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Article Pharmacology & Pharmacy

H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells

Ashley A. Untereiner et al.

BIOCHEMICAL PHARMACOLOGY (2017)

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Review Medicine, Research & Experimental

Hydrogen sulfide therapy in brain diseases: from bench to bedside

Ju-yi Zhang et al.

MEDICAL GAS RESEARCH (2017)

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Article Physiology

Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure

Erminia Donnarumma et al.

COMPREHENSIVE PHYSIOLOGY (2017)

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Article Cell Biology

Vascular biology of hydrogen sulfide

Nancy L. Kanagy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Biological chemistry of hydrogen sulfide and persulfides

Ernesto Cuevasanta et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)

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Review Oncology

Immune-based Therapies for Non-small Cell Lung Cancer

Hind Rafei et al.

ANTICANCER RESEARCH (2017)

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Review Biotechnology & Applied Microbiology

Gasotransmitters in cancer: from pathophysiology to experimental therapy

Csaba Szabo

NATURE REVIEWS DRUG DISCOVERY (2016)

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Article Cell Biology

Hydrogen sulfide promotes angiogenesis by downregulating miR-640 via the VEGFR2/mTOR pathway

Yu Zhou et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)

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Article Cardiac & Cardiovascular Systems

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels

Jay S. Naik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

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Article Chemistry, Multidisciplinary

A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals

Wei Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Review Chemistry, Multidisciplinary

A practical guide to working with H2S at the interface of chemistry and biology

Matthew D. Hartle et al.

CHEMICAL SOCIETY REVIEWS (2016)

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Review Physiology

Oxygen tension, H2S, and NO bioavailability: is there an interaction?

Gopi K. Kolluru et al.

JOURNAL OF APPLIED PHYSIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Cystathionine-β-Synthase Inhibition for Colon Cancer: Enhancement of the Efficacy of Aminooxyacetic Acid via the Prodrug Approach

Celia Chao et al.

MOLECULAR MEDICINE (2016)

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Article Biochemistry & Molecular Biology

Arecoline Induces Neurotoxicity to PC12 Cells: Involvement in ER Stress and Disturbance of Endogenous H2S Generation

Jia-Mei Jiang et al.

NEUROCHEMICAL RESEARCH (2016)

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Article Oncology

Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, migration effects and accelerates cell cycle progression in multiple myeloma cells via activating the Akt pathway

Dong Zheng et al.

ONCOLOGY REPORTS (2016)

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Article Oncology

Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells

Yiyan Lei et al.

ONCOLOGY REPORTS (2016)

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Review Cell Biology

Hydrogen Sulfide and Cellular Redox Homeostasis

Zhi-Zhong Xie et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Editorial Material Cell Biology

Gasotransmitters in Biology and Medicine: Molecular Mechanisms and Drug Targets

Guangdong Yang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Review Cell Biology

Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator

Sandesh Panthi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Review Pharmacology & Pharmacy

Regulation and role of endogenously produced hydrogen sulfide in angiogenesis

Antonia Katsouda et al.

PHARMACOLOGICAL RESEARCH (2016)

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Review Physiology

The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and Signaling

Kenneth R. Olson et al.

PHYSIOLOGY (2016)

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Article Oncology

Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer

Bo Su et al.

ONCOTARGET (2016)

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Review Pharmacology & Pharmacy

The Role of Hydrogen Sulfide in Renal System

Xu Cao et al.

FRONTIERS IN PHARMACOLOGY (2016)

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Article Multidisciplinary Sciences

Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

Bartosz Szczesny et al.

SCIENTIFIC REPORTS (2016)

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Article Pharmacology & Pharmacy

Cardioprotection by H2S Donors: Nitric Oxide-Dependent and -Independent Mechanisms

Athanasia Chatzianastasiou et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)

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Review Chemistry, Analytical

Fluorescence chemosensors for hydrogen sulfide detection in biological systems

Zhi Guo et al.

ANALYST (2015)

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Article Biochemistry & Molecular Biology

Role of cystathionine β-synthase in human breast Cancer

Suvajit Sen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

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Article Oncology

Exogenous hydrogen sulfide exerts proliferation/anti-apoptosis/angiogenesis/migration effects via amplifying the activation of NF-κB pathway in PLC/PRF/5 hepatoma cells

Yulan Zhen et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

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Article Biochemistry & Molecular Biology

Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

Ernesto Cuevasanta et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Review Biotechnology & Applied Microbiology

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

John L. Wallace et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide in cancer: Friend or foe?

Dongdong Wu et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2015)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide in renal physiology, disease and transplantation - The smell of renal protection

Anne M. Koning et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2015)

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Article Chemistry, Organic

Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides

Dong Liang et al.

ORGANIC LETTERS (2015)

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Review Cell Biology

The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential

Yaqi Shen et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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Article Cell Biology

An Anticancer Role of Hydrogen Sulfide in Human Gastric Cancer Cells

Li Zhang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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Article Cell Biology

Diallyl trisulfide inhibits migration, invasion and angiogenesis of human colon cancer HT-29 cells and umbilical vein endothelial cells, and suppresses murine xenograft tumour growth

Kuang-Chi Lai et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2015)

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Article Dentistry, Oral Surgery & Medicine

Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell lines

Z. Ma et al.

ORAL DISEASES (2015)

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Article Oncology

Role of the cystathionine gamma lyase/hydrogen sulfide pathway in human melanoma progression

Elisabetta Panza et al.

PIGMENT CELL & MELANOMA RESEARCH (2015)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide: A Neuromodulator and Neuroprotectant in the Central Nervous System

Xingzhou Zhang et al.

ACS CHEMICAL NEUROSCIENCE (2014)

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Article Chemistry, Multidisciplinary

Nanographene Oxide-Hyaluronic Acid Conjugate for Photothermal Ablation Therapy of Skin Cancer

Ho Sang Jung et al.

ACS NANO (2014)

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Article Chemistry, Multidisciplinary

Detection of Protein S-Sulfhydration by a Tag-Switch Technique

Dehui Zhang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

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Review Biochemistry & Molecular Biology

Production and Physiological Effects of Hydrogen Sulfide

Hideo Kimura

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Enzymology of H2S Biogenesis, Decay and Signaling

Omer Kabil et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Article Biotechnology & Applied Microbiology

Effects of pH and Lactate on Hydrogen Sulfide Production by Oral Veillonella spp.

Jumpei Washio et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2014)

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Article Cell Biology

Hydrogen sulphide triggers VEGF-induced intracellular Ca2+ signals in human endothelial cells but not in their immature progenitors

Duilio Michele Potenza et al.

CELL CALCIUM (2014)

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Review Cardiac & Cardiovascular Systems

Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease

David J. Polhemus et al.

CIRCULATION RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Hydrogen Sulfide and Endothelial Dysfunction: Relationship with Nitric Oxide

Zaid Altaany et al.

CURRENT MEDICINAL CHEMISTRY (2014)

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Review Developmental Biology

Lung development: orchestrating the generation and regeneration of a complex organ

Michael Herriges et al.

DEVELOPMENT (2014)

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Article Oncology

Differential susceptibility to hydrogen sulfide-induced apoptosis between PHLDA1-overexpressing oral cancer cell lines and oral keratinocytes: Role of PHLDA1 as an apoptosis suppressor

Takatoshi Murata et al.

EXPERIMENTAL CELL RESEARCH (2014)

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Article Gastroenterology & Hepatology

Carbon Monoxide, Hydrogen Sulfide, and Nitric Oxide as Signaling Molecules in the Gastrointestinal Tract

Gianrico Farrugia et al.

GASTROENTEROLOGY (2014)

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Article Oncology

GYY4137, a hydrogen sulfide ( H2S) donor, shows potent anti- hepatocellular carcinoma activity through blocking the STAT3 pathway

Sen Lu et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

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Review Endocrinology & Metabolism

Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin

Jenelle Govender et al.

JOURNAL OF PINEAL RESEARCH (2014)

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Article Pharmacology & Pharmacy

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro.

Mohammad R. Al-Magableh et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2014)

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Review Biochemistry & Molecular Biology

Role of hydrogen sulfide in secondary neuronal injury

Jun-Feng Wang et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

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Review Biochemistry & Molecular Biology

H2S during circulatory shock: Some unresolved questions

Oscar McCook et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide and the liver

Sarathi Mani et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)

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Article Multidisciplinary Sciences

A H2S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells

Reiko Sanokawa-Akakura et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos

Nannan Ning et al.

NATURE COMMUNICATIONS (2014)

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Article Chemistry, Multidisciplinary

Generation of HNO and HSNO from Nitrite by Heme-Iron-Catalyzed Metabolism with H2S

Jan Lj. Miljkovic et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)

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Review Pharmacology & Pharmacy

Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras

Khosrow Kashfi et al.

BIOCHEMICAL PHARMACOLOGY (2013)

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Article Oncology

Critical role for reactive oxygen species in apoptosis induction and cell migration inhibition by diallyl trisulfide, a cancer chemopreventive component of garlic

Kumar Chandra-Kuntal et al.

BREAST CANCER RESEARCH AND TREATMENT (2013)

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Review Cell Biology

Hydrogen sulfide as a regulator of calcium channels

Luca Munaron et al.

CELL CALCIUM (2013)

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Editorial Material Cell Biology

Endogenously produced hydrogen sulfide supports tumor cell growth and proliferation

Csaba Szabo et al.

CELL CYCLE (2013)

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Article Biochemistry & Molecular Biology

Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase

Pramod Kumar Yadav et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Oncology

Hydrogen sulfide-releasing aspirin inhibits the growth of leukemic Jurkat cells and modulates β-catenin expression

Mitali Chattopadhyay et al.

LEUKEMIA RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Physiological role of hydrogen sulfide and polysulfide in the central nervous system

Hideo Kimura

NEUROCHEMISTRY INTERNATIONAL (2013)

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Article Biochemistry & Molecular Biology

Hydrogen sulfide prevents OGD/R-induced apoptosis via improving mitochondrial dysfunction and suppressing an ROS-mediated caspase-3 pathway in cortical neurons

Yougen Luo et al.

NEUROCHEMISTRY INTERNATIONAL (2013)

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Review Biochemistry & Molecular Biology

Hydrogen sulfide chemical biology: Pathophysiological roles and detection

Gopi K. Kolluru et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2013)

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Article Multidisciplinary Sciences

Cystathionine Beta-Synthase (CBS) Contributes to Advanced Ovarian Cancer Progression and Drug Resistance

Sanjib Bhattacharyya et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

Csaba Szabo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Multidisciplinary Sciences

Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease

Huajian Teng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Article Chemistry, Organic

A highly sensitive fluorescent probe for imaging hydrogen sulfide in living cells

Huatang Zhang et al.

TETRAHEDRON LETTERS (2013)

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Article Multidisciplinary Sciences

A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells

Norihiro Shibuya et al.

NATURE COMMUNICATIONS (2013)

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Review Biochemistry & Molecular Biology

Redox biology of hydrogen sulfide: Implications for physiology, pathophysiology, and pharmacology

Asaf Stein et al.

REDOX BIOLOGY (2013)

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Article Pharmacology & Pharmacy

An Exogenous Hydrogen Sulphide Donor, NaHS, Inhibits the Nuclear Factor κB Inhibitor Kinase/Nuclear Factor κB Inhibitor/Nuclear Factor-κB Signaling Pathway and Exerts Cardioprotective Effects in a Rat Hemorrhagic Shock Model

Cao Gao et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2012)

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Article Cell Biology

Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines

Peng Yin et al.

CELLULAR SIGNALLING (2012)

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Article Biochemistry & Molecular Biology

A Novel Hydrogen Sulfide-releasing N-Methyl-D-Aspartate Receptor Antagonist Prevents Ischemic Neuronal Death

Eizo Marutani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Review Cell Biology

H2S signalling through protein sulfhydration and beyond

Bindu D. Paul et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

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Review Physiology

PHYSIOLOGICAL IMPLICATIONS OF HYDROGEN SULFIDE: A WHIFF EXPLORATION THAT BLOSSOMED

Rui Wang

PHYSIOLOGICAL REVIEWS (2012)

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Article Multidisciplinary Sciences

Solubility and Permeation of Hydrogen Sulfide in Lipid Membranes

Ernesto Cuevasanta et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Monitoring of Xenograft Tumor Growth and Response to Chemotherapy by Non-Invasive In Vivo Multispectral Fluorescence Imaging

Henrike Caysa et al.

PLOS ONE (2012)

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Article Multidisciplinary Sciences

Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation

Ciro Coletta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Chemistry, Medicinal

NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

Ravinder Kodela et al.

ACS MEDICINAL CHEMISTRY LETTERS (2012)

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Review

The cardioprotective potential of hydrogen sulfide in myocardial ischemia/reperfusion injury (Review)

E. Dongo et al.

ACTA PHYSIOLOGICA HUNGARICA (2011)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries

Ruth Pietri et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

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Review Pharmacology & Pharmacy

Hydrogen sulphide and angiogenesis: mechanisms and applications

Csaba Szabo et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

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Review Medicine, Research & Experimental

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

Matthew Whiteman et al.

CLINICAL SCIENCE (2011)

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Review Biochemistry & Molecular Biology

Old and New Gasotransmitters in the Cardiovascular System: Focus on the Role of Nitric Oxide and Hydrogen Sulfide in Endothelial Cells and Cardiomyocytes

Daniele Mancardi et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2011)

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Review Biochemistry & Molecular Biology

Hydrogen Sulfide Regulates Intracellular Ca2+ Concentration in Endothelial Cells From Excised Rat Aorta

Francesco Moccia et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2011)

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Article Gastroenterology & Hepatology

Endogenous Hydrogen Sulfide Is an Anti-inflammatory Molecule in Dextran Sodium Sulfate-Induced Colitis in Mice

Ikuhiro Hirata et al.

DIGESTIVE DISEASES AND SCIENCES (2011)

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Article Biochemistry & Molecular Biology

Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells

Emanuela Pupo et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

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Article Biochemistry & Molecular Biology

Measurement of plasma hydrogen sulfide in vivo and in vitro

Xinggui Shen et al.

FREE RADICAL BIOLOGY AND MEDICINE (2011)

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Article Pharmacology & Pharmacy

Significance of Hydrogen Sulfide Production in the Pancreatic β-Cell

Shigeki Taniguchi et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2011)

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Article Chemistry, Multidisciplinary

Reaction-Based Fluorescent Probes for Selective Imaging of Hydrogen Sulfide in Living Cells

Alexander R. Lippert et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Biochemistry & Molecular Biology

Cardioprotective effects of hydrogen sulfide

Gabor Szabo et al.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2011)

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Article Multidisciplinary Sciences

The Slow-Releasing Hydrogen Sulfide Donor, GYY4137, Exhibits Novel Anti-Cancer Effects In Vitro and In Vivo

Zheng Wei Lee et al.

PLOS ONE (2011)

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Article Multidisciplinary Sciences

H2S Donor, S-Propargyl-Cysteine, Increases CSE in SGC-7901 and Cancer-Induced Mice: Evidence for a Novel Anti-Cancer Effect of Endogenous H2S?

Kaium Ma et al.

PLOS ONE (2011)

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Article Critical Care Medicine

THE LIVER AS A CENTRAL REGULATOR OF HYDROGEN SULFIDE

Eric J. Norris et al.

SHOCK (2011)

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Article Biochemistry & Molecular Biology

The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages

Matthew Whiteman et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Article Biochemistry & Molecular Biology

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

Yuka Kimura et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

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Review Biochemistry & Molecular Biology

Regulation of cardiovascular cell function by hydrogen sulfide (H2S)

David J. Elsey et al.

CELL BIOCHEMISTRY AND FUNCTION (2010)

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Article Cell Biology

Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21

Wen-Jie Cai et al.

CELL BIOLOGY INTERNATIONAL (2010)

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Article Pharmacology & Pharmacy

Mechanisms of angiogenesis: Role of hydrogen sulphide

Ming-Jie Wang et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2010)

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Review Oncology

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

Adriana Albini et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

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Article Pharmacology & Pharmacy

Detection of exhaled hydrogen sulphide gas in rats exposed to intravenous sodium sulphide

Michael A. Insko et al.

BRITISH JOURNAL OF PHARMACOLOGY (2009)

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Article Multidisciplinary Sciences

Hydrogen sulfide is an endogenous stimulator of angiogenesis

Andreas Papapetropoulos et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Biochemistry & Molecular Biology

Signaling by Gasotransmitters

Asif K. Mustafa et al.

SCIENCE SIGNALING (2009)

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Article Biochemistry & Molecular Biology

H2S Signals Through Protein S-Sulfhydration

Asif K. Mustafa et al.

SCIENCE SIGNALING (2009)

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Article Physiology

Reappraisal of H2S/sulfide concentration in vertebrate blood and its potential significance in ischemic preconditioning and vascular signaling

Nathan L. Whitfield et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)

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Article Physiology

Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

Julie Furne et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2008)

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Article Multidisciplinary Sciences

H2S as a physiologic vasorelaxant:: Hypertension in mice with deletion of cystathionine γ-lyase

Guangdong Yang et al.

SCIENCE (2008)

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Article Multidisciplinary Sciences

Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans

Dana L. Miller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Multidisciplinary Sciences

Hydrogen sulfide mediates the vasoactivity of garlic

Gloria A. Benavides et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Review Pharmacology & Pharmacy

Hydrogen sulfide-releasing anti-inflammatory drugs

John L. Wallace

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

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Article Oncology

Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence

Victoria L. Stevens et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)

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Article Biology

Hydrogen sulfide as an oxygen sensor/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation

Kenneth R. Olson et al.

JOURNAL OF EXPERIMENTAL BIOLOGY (2006)

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Article Biochemical Research Methods

Polarographic measurement of hydrogen sulfide production and consumption by mammalian tissues

JE Doeller et al.

ANALYTICAL BIOCHEMISTRY (2005)

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Article Biochemistry & Molecular Biology

Two's company, three's a crowd:: can H2S be the third endogenous gaseous transmitter?

R Wang

FASEB JOURNAL (2002)

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Article Biochemistry & Molecular Biology

Brain hydrogen sulfide is severely decreased in Alzheimer's disease

K Eto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

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Article Toxicology

Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: Correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium

DC Dorman et al.

TOXICOLOGICAL SCIENCES (2002)

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Article Biochemistry & Molecular Biology

The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

WM Zhao et al.

EMBO JOURNAL (2001)

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Hydrogen Sulfide (H2S): As a Potent Modulator and Therapeutic Prodrug in Cancer

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