Journal
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
Volume 180, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2022.103822
Keywords
Biomarkers; Cancer; Cancer-related cognitive impairment; Chemotherapy-related cognitive impairment; Cytokines; Scoping review
Categories
Funding
- Lawrence S. Bloomberg Faculty of Nursing, University of Toronto
- Oncology Nursing Foundation
- National Institute of Nursing Research of the National Institutes of Health [T32NR016920]
Ask authors/readers for more resources
This scoping review aims to synthesize the existing literature on the associations between subjective and/or objective measures of cancer-related cognitive impairment (CRCI) and blood-based biomarkers in adults with non-central nervous system cancers. A total of 95 studies were included, and significant correlations were found between various subjective and objective measures of CRCI and levels of interleukin-6 and tumor necrosis factor.
This scoping review was designed to synthesize the extant literature on associations between subjective and/or objective measures of cancer-related cognitive impairment (CRCI) and blood-based biomarkers in adults with non-central nervous system cancers. The literature search was done for studies published from the start of each database searched (i.e., MEDLINE, Embase, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, grey literature) through to October 20, 2021. A total of 95 studies are included in this review. Of note, a wide variety of biomarkers were evaluated. Most studies evaluated patients with breast cancer. A variety of cognitive assessment measures were used. The most consistent significant findings were with various subjective and objective measures of CRCI and levels of interleukin-6 and tumor necrosis factor. Overall, biomarker research is in an exploratory phase. However, this review synthesizes findings and proposes directions for future research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available