☆ 4.7 Review

Dietary restriction in senolysis and prevention and treatment of disease

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Senolytic drugs: from discovery to translation

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Ketogenic diet attenuates aging-associated myocardial remodeling and dysfunction in mice

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Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle

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Fasting, dietary restriction, and immunosenescence

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Ketogenic diet aggravates cardiac remodeling in adult spontaneously hypertensive rats

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Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

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Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells

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Age-dependent effects of caloric restriction on mTOR and ubiquitin-proteasome pathways in skeletal muscles

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Targeting senescent cells alleviates obesity-induced metabolic dysfunction

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Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice

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Ghrelin Plasma Levels After 1 Year of Ketogenic Diet in Children With Refractory Epilepsy

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A Ketone Ester Drink Lowers Human Ghrelin and Appetite

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Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism

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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

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Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging

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Short-Term, Intermittent Fasting Induces Long-Lasting Gut Health and TOR-Independent Lifespan Extension

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Senolytics improve physical function and increase lifespan in old age

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Caloric restriction mitigates age-associated hippocampal differential CG and non-CG methylation

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Ketogenic diet attenuates oxidative stress and inflammation after spinal cord injury by activating Nrf2 and suppressing the NF-κB signaling pathways

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Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice

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β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle

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Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Ketogenic Diet Modulates NAD(+)-Dependent Enzymes and Reduces DNA Damage in Hippocampus

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Fisetin is a senotherapeutic that extends health and lifespan

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Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma

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Caloric restriction and cellular senescence

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Impaired immune surveillance accelerates accumulation of senescent cells and aging

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Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates

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Conserved and novel functions of programmed cellular senescence during vertebrate development

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Metformin alters DNA methylation genome-wide via the H19/SAHH axis

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Targeting cellular senescence prevents age-related bone loss in mice

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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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Impact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adults

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Caloric restriction improves health and survival of rhesus monkeys

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Caloric restriction delays age-related methylation drift

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A ketogenic diet supplemented with medium-chain triglycerides enhances the anti-tumor and anti-angiogenic efficacy of chemotherapy on neuroblastoma xenografts in a CD1-nu mouse model

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Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

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Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3I

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Longevity is impacted by growth hormone action during early postnatal period

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Senescence gives insights into the morphogenetic evolution of anamniotes

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Ketone-Based Metabolic Therapy: Is Increased NAD+ a Primary Mechanism?

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Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

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System-wide Benefits of Intermeal Fasting by Autophagy

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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling

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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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D--hydroxybutyrate promotes functional recovery and relieves pain hypersensitivity in mice with spinal cord injury

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Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

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Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

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Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons

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Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation

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Enhanced immunity in a mouse model of malignant glioma is mediated by a therapeutic ketogenic diet

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Epigenetic Mechanisms of Longevity and Aging

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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

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A putative low-carbohydrate ketogenic diet elicits mild nutritional ketosis but does not impair the acute or chronic hypertrophic responses to resistance exercise in rodents

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Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Ghrelin is the metabolic link connecting calorie restriction to neuroprotection

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Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

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Senescent intimal foam cells are deleterious at all stages of atherosclerosis

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Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

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Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet

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DNA Methylation on N6-Adenine in C-elegans

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A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

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Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver

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The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

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SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing

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SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice

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Metabolic Control of Autophagy

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Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression

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Calorie Restriction is a Major Determinant of the Short-Term Metabolic Effects of Gastric Bypass Surgery in Obese Type 2 Diabetic Patients

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Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice

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Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance

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Geriatric muscle stem cells switch reversible quiescence into senescence

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Metformin-mode of action and clinical implications for diabetes and cancer

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Cellular senescence: from physiology to pathology

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Ghrelin: A link between ageing, metabolism and neurodegenerative disorders

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Fasting Increases Human Skeletal Muscle Net Phenylalanine Release and This Is Associated with Decreased mTOR Signaling

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Aging of blood can be tracked by DNA methylation changes at just three CpG sites

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Epigenetic Rejuvenation of Mesenchymal Stromal Cells Derived from Induced Pluripotent Stem Cells

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Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

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Programmed Cell Senescence during Mammalian Embryonic Development

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Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

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Pluripotent stem cells escape from senescence-associated DNA methylation changes

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Endothelial progenitor cells in smokers are dysfunctional because of increased DNA damage and senescence

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Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

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A complex secretory program orchestrated by the inflammasome controls paracrine senescence

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Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial

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Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice

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Steve Horvath

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Global DNA methylation in old subjects is correlated with frailty

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AGE (2012)

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IL1-and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'Bystander senescence'

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Metabolic Actions of Insulin-Like Growth Factor-I in Normal Physiology and Diabetes

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ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2012)

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The sirtuin SIRT6 regulates lifespan in male mice

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Senescent cells develop a PARP-1 and nuclear factor-κB-associated secretome (PNAS)

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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2011)

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Cellular senescence controls fibrosis in wound healing

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TGF-β and Insulin Signaling Regulate Reproductive Aging via Oocyte and Germline Quality Maintenance

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Glucose restriction can extend normal cell lifespan and impair precancerous cell growth through epigenetic control of hTERT and p16 expression

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Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer

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Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

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GENOME RESEARCH (2010)

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Widespread and tissue specific age-related DNA methylation changes in mice

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Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

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Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

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SASP reflects senescence

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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MECHANISMS OF AGEING AND DEVELOPMENT (2009)

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

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DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons

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Dietary deprivation extends lifespan in Caenorhabditis elegans

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: Effect of alternate-day fasting

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MECHANISMS OF AGEING AND DEVELOPMENT (2005)

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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SIR2 is required for Polycomb silencing and is associated with an E(Z) histone methytransferase complex

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Epigenetics in human disease and prospects for epigenetic therapy

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Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: Cross-sectional and interventional studies

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Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

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Longevity - Extending the lifespan of long-lived mice

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

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