Journal
COORDINATION CHEMISTRY REVIEWS
Volume 472, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ccr.2022.214780
Keywords
Photosensitizer; Singlet oxygen quantum yield; Intersystem crossing; Aggregation -induced emission; Photodynamic therapy
Categories
Funding
- National Natural Science Foundation of China [62175262, 62105184]
- Innovation-Driven Project of Central South University [2020CX021]
- Fundamental Research Funds for Central Universities of the Central South University [2021zzts0556]
- Natural Science Foundation of Shandong Province, China [2022HWYQ-007, ZR2021QB043]
- Special Fund of Taishan Scholars Project of Shandong Province, China [tsqn201909012]
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This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.
Singlet oxygen (O-1(2)) generation is an essential function of photosensitizer (PS) as applied to photody-namic therapy (PDT) of cancer. As illustrated in the Jablonski diagram, the generation of O-1(2) is directly related to the process of intersystem crossing (ISC), in which a high ISC efficiency typically correlates with a high quantum yield (QY) of O-1(2). In recent years, multiple strategies have been adopted to improve ISC efficiency, including tuning chemical structures and reducing aggregation-caused quenching (ACQ), thus increase the O-1(2) QY of PS. Here, we systematically summarize and compare the advantages and disadvantages of these strategies through analysis of some representative examples. In addition, we also discuss the challenges and obstacles encountered in the development of PS with high O-1(2) generation efficiency and propose directions for future clinical applications of PDT. (c) 2022 Elsevier B.V. All rights reserved.
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