Advanced nanovaccines based on engineering nanomaterials for accurately enhanced cancer immunotherapy

Review Oncology

Plant lectins and their usage in preparing targeted nanovaccines for cancer immunotherapy

Bhavika Gupta et al.

Summary: Glycans extracted from plant lectins can act as ligands for immune cells and may lead to the development of new targeted therapies. Understanding the structure of these glycans is crucial for developing alternative targeted therapies.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Chemistry, Multidisciplinary

Whole-Cell-Mimicking Carrier-Free Nanovaccines Amplify Immune Responses Against Cancer and Bacterial Infection

Ming Qin et al.

Summary: A simple strategy has been developed to convert whole-cell vaccines into nanoscale size to promote their lymphatic migration and intracellular antigen presentation, aiming to enhance immune responses. The universal carrier-free nano-vaccine fabricated through a two-step vortex-sonification method based on alum-induced and cancer/bacterial cell membrane coated protein antigen nanoparticles can efficiently migrate to lymph nodes after subcutaneous vaccination, where they are taken up by APCs for antigen presentation and activation of immune processes.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

Jing Liu et al.

Summary: Cancer vaccines aim to stimulate tumor-specific immune responses while sparing normal tissues, with bioinspired materials and technologies playing a role in reshaping the field of cancer nanomedicine. By mimicking desirable properties in nature, bioinspired engineering of cancer vaccine delivery platforms can enhance therapeutic efficacy and safety profiles for clinical translation.

ADVANCED MATERIALS (2022)

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Article Oncology

Cancer immunotherapy using artificial adjuvant vector cells to deliver NY-ESO-1 antigen to dendritic cells in situ

Shin-ichiro Fujii et al.

Summary: The artificial adjuvant vector cell (aAVC-NY-ESO-1) successfully induced NY-ESO-1-specific CTL response in tumors and promoted the maturation of dendritic cells (DCs), resulting in a strong antitumor effect.

CANCER SCIENCE (2022)

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Review Chemistry, Inorganic & Nuclear

Mitochondria targeted fluorogenic theranostic agents for cancer therapy

Hardev Singh et al.

Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.

COORDINATION CHEMISTRY REVIEWS (2022)

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Article Oncology

Acute myeloid leukemia cell membrane-coated nanoparticles for cancer vaccination immunotherapy

Daniel T. Johnson et al.

Summary: AMCNP vaccine platform, coated with AML cell membrane material, enhances leukemia-specific antigen presentation and T cell responses, demonstrating promising therapeutic benefits against AML challenge and potentially preventing relapse after chemotherapy.

LEUKEMIA (2022)

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Article Multidisciplinary Sciences

Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth

Jialu Xu et al.

Summary: This article discusses the research progress of microbe-based cancer immunotherapy, inducing anticancer immunity through the preparation of nanoparticles of different sizes. The study found that the size of the formulations inversely correlates with their accumulation ability in tumor-draining lymph nodes, showing potential therapeutic effects.

NATURE COMMUNICATIONS (2022)

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Review Materials Science, Biomaterials

Nanotechnology-Based Approaches to Promote Lymph Node Targeted Delivery of Cancer Vaccines

Ruiqing He et al.

Summary: Vaccines are a promising immunotherapy for inhibiting and eliminating cancer with fewer side effects. However, there are still issues with the immune effects and therapeutic outcomes of cancer vaccines. This review outlines the latest advances in nanotechnology for improving vaccine effectiveness.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2022)

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Article Chemistry, Multidisciplinary

Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency

Yunhao Wang et al.

Summary: This study develops a novel immunotherapy strategy for hepatocellular carcinoma (HCC) by using an acidic/photo-sensitive dendritic cell-based neoantigen nano-vaccine. The nano-vaccine converts the tumor from an immunologically cold state to a hot state and enhances the immune response by remodeling tumor-associated neutrophils. The results show promising efficacy in tumor regression and prolonged survival time in mice.

ADVANCED SCIENCE (2022)

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Article Pharmacology & Pharmacy

Emerging vaccine nanotechnology: From defense against infection to sniping cancer

Chan Feng et al.

Acta Pharmaceutica Sinica B (2022)

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Article Engineering, Biomedical

Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy

Jie Chen et al.

Summary: This study explores an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines with gene regulated PD-L1 blockade. The mannose modified nanovaccines can effectively co-encapsulate antigen and adjuvant, promoting endocytosis and cross presentation in dendritic cells. However, the limited inhibition of tumor growth by nanovaccines in the immunosuppressed tumor microenvironment can be overcome by combining with gene regulated PD-L1 blockade, leading to significant tumor remission.

BIOACTIVE MATERIALS (2022)

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Review Pharmacology & Pharmacy

Nanovaccines with cell-derived components for cancer immunotherapy

Zhouqi Meng et al.

Summary: This review article explores the recent research progress of cell-derived biomimetic nanovaccines for cancer immunotherapy, and discusses the perspectives and challenges associated with the future clinical translation of these emerging vaccine platforms.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Chemistry, Inorganic & Nuclear

Activity-based fluorescence probes for pathophysiological peroxynitrite fluxes

Zhiqiang Mao et al.

Summary: This article reviews the research on activity-based sensing (ABS) fluorescent probes that reveal the vital roles of peroxynitrite (ONOO-) in various diseases. ABS fluorescent probes, as a molecular imaging technique, have advantages such as sensitive and selective detection results, non-invasive and real-time visualization.

COORDINATION CHEMISTRY REVIEWS (2022)

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Review Nanoscience & Nanotechnology

Peptide-Based Nanovaccines in the Treatment of Cervical Cancer: A Review of Recent Advances

Jiahui Zhang et al.

Summary: HPV infection is a major cause of cervical cancer, and prophylactic HPV vaccines can help prevent it. However, there is currently no approved therapeutic HPV vaccine for existing infections. Peptide-based nanovaccines have shown promise in inducing immune responses and eliminating tumor cells, and hold potential for combating HPV infection.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Chemistry, Multidisciplinary

Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy

Yeon Jeong Yoo et al.

Summary: This review discusses the use of nanoparticle-based delivery strategies to enhance the therapeutic efficacy of RNA-based immunomodulation in cancer immunotherapy. Various nanoparticle-based delivery systems have been reported to improve RNA stability, cellular uptake, and accumulation at the desired sites, overcoming the biological barriers associated with RNA therapeutics. Nanotechnology-assisted RNA-based therapeutics have the potential to significantly advance the treatment of cancer, viral infections, and other diseases.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Surgical Tumor-Derived Photothermal Nanovaccine for Personalized Cancer Therapy and Prevention

Tan Li et al.

Summary: Recent breakthroughs in cell membrane-fabricated nanovaccine have provided innovative therapeutic options for preventing tumor metastasis and recurrence. However, the immunosuppressive tumor microenvironment makes personalized treatment of solid tumors challenging. In this study, a personalized photothermal nanovaccine was developed based on surgical-loaded mesoporous polydopamine nanoparticles, which showed outstanding imaging-guided photothermal immunotherapy efficacy and inhibited metastasis tumors by inducing antitumor immunities, especially in combination with aPD-L1 therapy. Prophylactic testing results confirmed that the photothermal nanovaccine can prevent rechallenge of 4T1 cells by 100% in a postsurgical tumor model. This work demonstrates the potential of personalized photothermal nanovaccine for tumor-specific treatment and prevention of postoperative tumor recurrence.

NANO LETTERS (2022)

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Article Nanoscience & Nanotechnology

A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

Chao Liu et al.

Summary: This study presents a genetically engineered cell membrane nanovesicle for cancer immunotherapy. The nanovaccine, named ASPIRE, can improve antigen delivery to lymphoid organs and generate broad-spectrum T-cell responses that eliminate established tumors. This work provides a powerful vaccine formula that can directly activate both native T cells and exhausted T cells, suggesting a general strategy for personalized cancer immunotherapy.

NATURE NANOTECHNOLOGY (2022)

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Article Cell Biology

Antigen Cross-Presentation by Murine Proximal Tubular Epithelial Cells Induces Cytotoxic and Inflammatory CD8+ T Cells

Alexandra Linke et al.

Summary: This study found that proximal tubular epithelial cells (PTECs) have the capacity for antigen cross-presentation, which can modulate the immune response in immune-mediated glomerular diseases, such as lupus nephritis.

CELLS (2022)

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Article Pharmacology & Pharmacy

A biomimetic antitumor nanovaccine based on biocompatible calcium pyrophosphate and tumor cell membrane antigens

Minghui Li et al.

Summary: This study proposed a biomimetic antitumor nanovaccine based on biocompatible nanocarriers and tumor cell membrane antigens, with calcium pyrophosphate nanogranules serving as both delivery vehicles and adjuvants. The biomimetic vaccine demonstrated strong T-cell response, excellent tumor therapy and prophylactic effects, as well as nice biocompatibility, showing potential for further design and application of antitumor vaccines.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Oncology

CD19-specific CAR T Cells that Express a PD-1/CD28 Chimeric Switch-Receptor are Effective in Patients with PD-L1-positive B-Cell Lymphoma

Hui Liu et al.

Summary: The study demonstrates that CD19-PD-1/CD28-CAR T cells have better efficacy in treating PD-L1 positive B-cell lymphoma compared to CD19-CAR T cells. Among 17 patients who received CAR T therapy, 58.8% had objective response with 41.2% achieving complete remission at a median follow-up of 15 months. No severe neurological toxicity or cytokine release syndrome was observed.

CLINICAL CANCER RESEARCH (2021)

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Review Pharmacology & Pharmacy

CD33-Targeted Therapies: Beating the Disease or Beaten to Death?

Joseph E. Maakaron et al.

Summary: CD33 is a transmembrane protein that is highly expressed on AML progenitor cells, making it a specific target for AML therapeutics. Various targeted therapies, including gemtuzumab ozogamicin, have been developed, but more precise strategies such as cellular therapy mechanisms and linker molecules are currently being explored for clinical benefit.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

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Article Chemistry, Multidisciplinary

3D Printing Scaffold Vaccine for Antitumor Immunity

Yue Zhang et al.

Summary: A 3D printed scaffold loaded with immunoregulators has been developed for enhanced cancer immunotherapy, showing potential as a strategy for cancer vaccine therapy in the future.

ADVANCED MATERIALS (2021)

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Article Engineering, Biomedical

Therapeutic vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen

Xiaoling Xie et al.

Summary: In this study, co-encapsulation of a leukaemia-associated epitope peptide and anti-PD-1 antibody in degradable microcapsules led to sustained release and improved therapeutic outcomes in mouse models. The recruitment of activated antigen-presenting cells, expansion of epitope-specific T cells, and activation of cytotoxic T cells were enhanced by this strategy.

NATURE BIOMEDICAL ENGINEERING (2021)

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Review Nanoscience & Nanotechnology

Nanomaterials for T-cell cancer immunotherapy

Ningqiang Gong et al.

Summary: T-cell-based immunotherapies show promise in treating cancer, but face challenges such as insufficient expansion of transferred T cells and inefficient trafficking into tumors. Nanomaterials offer a solution to enhance T-cell therapy by overcoming physical barriers and modulating tumor microenvironments.

NATURE NANOTECHNOLOGY (2021)

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Review Oncology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

Eryn Blass et al.

Summary: Immunotherapy has revolutionized cancer treatment with the development of immune-checkpoint inhibitors and personalized neoantigen vaccines. These vaccines trigger specific T cell responses against individual patient's tumors, showing promising tumor-specific immunogenicity and antitumor activity.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Chemistry, Multidisciplinary

A Multifunctional Nanovaccine based on L-Arginine-Loaded Black Mesoporous Titania: Ultrasound-Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy

Meifang Wang et al.

Summary: The multifunctional nanovaccine based on BMT@LA combined with αPD-L1 antibody can induce a strong antitumor immune response, effectively killing primary tumors and inhibiting metastatic tumors. This combination treatment realizes synergetic sonodynamic/gas/immunotherapy with enhanced antitumor therapeutic effects.

SMALL (2021)

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Article Oncology

Biologic subtypes of melanoma predict survival benefit of combination anti-PD1+anti-CTLA4 immune checkpoint inhibitors versus anti-PD1 monotherapy

April A. N. Rose et al.

Summary: The study found that primary melanoma tumor type and genomic subtype serve as independent predictive markers of clinical progression-free survival and overall survival in patients with metastatic melanoma receiving anti-PD1 ICI. Further evaluation in prospective clinical trials is needed to determine the value of primary tumor type and genomic subtype, including NRAS, as predictive markers. Biologic subtypes may aid in clinical decision-making when deciding between combination ICI treatment (anti-PD1 +/- anti-CTLA4) versus anti-PD1 alone for patients with metastatic melanoma.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

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Article Immunology

Liposomal Nanovaccine Containing α-Galactosylceramide and Ganglioside GM3 Stimulates Robust CD8+ T Cell Responses via CD169+ Macrophages and cDC1

Joanna Grabowska et al.

Summary: Successful anti-cancer vaccines targeting cytotoxic T cells and immune cell interactions through GM3-alpha GC-OVA liposomes show promising results in inducing strong adaptive immunity against cancer. The activation of CD8(+) T cells, NKT, and NK cells plays a critical role in the potent immune response, highlighting the potential of this vaccine platform for anti-cancer strategies.

VACCINES (2021)

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Review Engineering, Biomedical

Nanobiomaterial-based vaccination immunotherapy of cancer

Fangmin Chen et al.

Summary: Cancer vaccines, including antigen peptide/adjuvant-based nanovaccines, nucleic acid-based nanovaccines, and biomimetic nanobiomaterials-based nanovaccines, have shown significant efficacy in inhibiting tumor growth and preventing relapse and metastasis. However, challenges remain in the clinical translation of these vaccines. The use of various nanobiomaterials has great potential to enhance the efficacy of cancer vaccines and reduce off-target effects.

BIOMATERIALS (2021)

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Review Pharmacology & Pharmacy

Cell-penetrating Peptide-mediated Nanovaccine Delivery

Jizong Jiang

Summary: Vaccination with small antigens is used to activate the immune system to trigger protective immune responses against pathogens. Nanovaccines, in the size range of 10-500 nm, are being developed to replace conventional vaccines, offering improved safety profiles. However, challenges such as low-level immune responses and toxicity exist, with cell-penetrating peptide (CPP)-mediated nanovaccines as a potential solution to enhance antigen uptake and presentation by immune cells.

CURRENT DRUG TARGETS (2021)

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Article Chemistry, Multidisciplinary

Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy

Zhouqi Meng et al.

Summary: This study presents an ultrasound-responsive self-healing hydrogel system for controlled tumor vaccine release and personalized cancer immunotherapy. Through multiple ultrasound treatments, nanovaccines could be repeatedly released from the gel to elicit antitumor immune responses, effectively inhibiting established tumors and preventing postoperative tumor metastases and recurrence.

NANO LETTERS (2021)

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Article Chemistry, Physical

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR-Cas gene editing

Shuai Liu et al.

Summary: The study successfully delivered mRNA or single-guide RNA for gene editing in vivo using combinatorially synthesized ionizable phospholipids. Optimized iPhos lipids can change shapes in endosomal acidic environments to facilitate the release of gene editing materials. When working synergistically with helper lipids, iPhos lipids can achieve targeted delivery to specific organs.

NATURE MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Ilio Vitale et al.

Summary: Tumors evolve under various pressures and exhibit considerable heterogeneity in genetic, phenotypic, and behavioral aspects. This intratumoral heterogeneity influences disease progression and treatment sensitivity, necessitating consideration of multiple levels of heterogeneity in future therapeutic approaches.

NATURE MEDICINE (2021)

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Article Nanoscience & Nanotechnology

Molybdenum derived from nanomaterials incorporates into molybdenum enzymes and affects their activities in vivo

Mingjing Cao et al.

Summary: Understanding the in vivo biotransformation of nanomaterials, such as molybdenum derived from MoS2, can shed light on their long-term effects on liver metabolism. Through a combination of in vivo experiments and molecular dynamics simulations, the study reveals that the biodistribution of molybdenum is mediated by protein coronas, mainly with apolipoprotein E, leading to increased enzyme activities in the liver. The findings suggest that nanomaterials consisting of essential trace elements may be converted into active biological molecules in organisms.

NATURE NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

Hongxia Zhang et al.

Summary: The C1 lipid nanoparticle-based mRNA cancer nanovaccine efficiently delivers mRNA to antigen presenting cells, activates TLR4, induces inflammatory cytokines in dendritic cells, and shows significant antitumor efficacy.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Chemistry, Multidisciplinary

HPV-Associated Tumor Eradication by Vaccination with Synthetic Short Peptides and Particle-Forming Liposomes

Xuedan He et al.

Summary: The study shows that a peptide-liposome vaccine based on E7(HHH49-57) is effective in combating HPV-related cervical cancers and tumor challenges, with other peptide epitopes showing lower efficacy. A nanogram dose of peptide admixed with CoPoP liposomes provides protection in therapeutic tumor challenges, inducing a strong infiltrating CD8(+) T-cell response within the tumor microenvironment.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity

Da Zhang et al.

Summary: A thiolated nano-vaccine was developed to deliver neoantigens and TLR9 agonist CpG-ODN directly into the cytosol, bypassing degradation pathways and enhancing antigen uptake, leading to increased anti-cancer T-cell immunity. In vivo immunization with this vaccine inhibited tumor growth, prolonged survival, and combining it with anti-PD-1 antibody further enhanced immune response and tumor elimination.

ADVANCED SCIENCE (2021)

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Article Immunology

PLGA Nanoparticles Co-encapsulating NY-ESO-1 Peptides and IMM60 Induce Robust CD8 and CD4 T Cell and B Cell Responses

Yusuf Dolen et al.

Summary: A PLGA-based nanoparticle vaccine containing immunogenic cancer germline antigen NY-ESO-1 and iNKT cell agonist was developed, which efficiently induced antigen-specific T cell responses in vivo without systemic toxicity at high doses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Manufacturing NKG2D CAR-T cells with piggyBac transposon vectors and K562 artificial antigen-presenting cells

Johan C. K. Tay et al.

Summary: Non-viral platforms were used to generate large numbers of efficacious NKG2D CAR-T cells suitable for multiple infusions. Cryopreservation and post-thaw expansion methods maintained cell activity, and interestingly, extended manufacturing reduced the expression of T cell exhaustion markers. Additionally, incorporating a CD20 transgene enhanced safety by enabling autologous NK cells to remove the CAR-T cells.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

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Article Engineering, Biomedical

Prolonged activation of innate immune pathways by a polyvalent STING agonist

Suxin Li et al.

Summary: A novel polyvalent STING agonist extends the activation of innate-immunity pathways through the formation of STING condensates and leads to synergistic therapeutic outcomes in vivo when combined with the STING ligand cGAMP.

NATURE BIOMEDICAL ENGINEERING (2021)

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Article Chemistry, Multidisciplinary

ATP-Responsive Smart Hydrogel Releasing Immune Adjuvant Synchronized with Repeated Chemotherapy or Radiotherapy to Boost Antitumor Immunity

Lele Sun et al.

Summary: A smart hydrogel has been developed to release immune adjuvants in response to repeated low-dose chemo/radiotherapies, enhancing antitumor immunity. By synchronizing the release of immune adjuvants with tumor cell death, the hydrogel demonstrates remarkable synergistic effects in eliminating established tumors and promoting immune memory.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Development of a Cancer Vaccine Using In Vivo Click-Chemistry-Mediated Active Lymph Node Accumulation for Improved Immunotherapy

Hao Qin et al.

Summary: The development of an active lymph node accumulation system (ALAS) using click chemistry has shown promising results in enhancing the delivery of cancer vaccine components to lymph nodes, leading to improved antitumor immunity.

ADVANCED MATERIALS (2021)

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Review Biotechnology & Applied Microbiology

Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy

Ting Cai et al.

Summary: Research has shown that poor delivery of nanovaccines to lymphoid organs limits the rapid induction of anti-tumor immune response. Optimizing the physicochemical properties of nanovaccines and designing dynamic structures can enhance their accumulation in lymphoid organs and achieve precise targeted delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Medicine, Research & Experimental

Smart exosomes with lymph node homing and immune-amplifying capacities for enhanced immunotherapy of metastatic breast cancer

Panpan Ji et al.

Summary: A novel type of smart exosomes was developed, with engineered surfaces that showed strong TDLN homing capacity in a mouse model and activated effector T cells while inhibiting Treg induction to enhance anti-tumor immune responses.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Editorial Material Nanoscience & Nanotechnology

Clinical translation of silica nanoparticles

Taskeen Iqbal Janjua et al.

Summary: Silica nanoparticles have shown promising safety, efficacy, and viability in clinical trials for various biomedical applications such as oral drug delivery, diagnostics, and therapy, indicating their potential in the field.

NATURE REVIEWS MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Recent advances in tumor microenvironment-targeted nanomedicine delivery approaches to overcome limitations of immune checkpoint blockade-based immunotherapy

Jaehyun Kim et al.

Summary: Cancer immunotherapy has greatly improved the standard of care for solid tumors, with immune checkpoint blockade targeting immunosuppressive mechanisms. However, the overall response rate to immune checkpoint blockades is low, with some patients experiencing severe immune-related adverse events. The failure of immune checkpoint blockades is primarily attributed to the tumor microenvironment, leading to current research focusing on targeting and suppressing the immunosuppressive characteristics within the tumor microenvironment.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Multidisciplinary

Advances in receptor modulation strategies for flexible, efficient, and enhanced antitumor efficacy

Dan-Dan Wang et al.

Summary: Modulating receptors on tumor cells is crucial for enhancing targeted therapy, improving treatment concentration, and increasing effectiveness.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Engineering, Biomedical

Polysaccharide-based nanomedicines for cancer immunotherapy: A review

Yujun Zeng et al.

Summary: Polysaccharide-based nanoparticles can be used to enhance antitumor immune responses with reduced toxicity and side effects by carrying immunotherapeutics.

BIOACTIVE MATERIALS (2021)

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Article Medicine, Research & Experimental

Toll-like Receptor-4 (TLR4) Agonist-Based Intranasal Nanovaccine Delivery System for Inducing Systemic and Mucosal Immunity

Mohammed Ali Bakkari et al.

Summary: InAc-NPs, as an intranasal vaccine delivery system, can activate macrophages and stimulate the secretion of sIgA at mucosal sites, indicating both cellular and humoral immune activation.

MOLECULAR PHARMACEUTICS (2021)

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Review Chemistry, Multidisciplinary

Nanovaccine-Based Strategies to Overcome Challenges in the Whole Vaccination Cascade for Tumor Immunotherapy

Lin Qin et al.

Summary: Emerging NBI strategies aim to enhance the efficacy of nanovaccines in each step of the LDIMP cascade by addressing challenges at five critical cascading events; in the fight against cancer, a balance between each step must be optimized through delicate design and modification of nanovaccines, combined with complementary approaches to provide a synergistic immunity.

SMALL (2021)

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Article Multidisciplinary Sciences

Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology

Keman Cheng et al.

Summary: The study demonstrates a versatile OMV-based vaccine platform that can elicit a specific anti-tumor immune response by specifically presenting tumor antigens on the OMV surface. By employing a Plug-and-Display system, the engineered OMVs can simultaneously display multiple, distinct tumor antigens to promote a synergistic anti-tumor immune response.

NATURE COMMUNICATIONS (2021)

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Review Oncology

CAR-T cell therapy: current limitations and potential strategies

Robert C. Sterner et al.

Summary: CAR-T cell therapy has shown remarkable clinical responses in certain subsets of leukemia or lymphoma, but faces challenges in solid tumors and hematological malignancies. Innovative strategies and approaches are necessary to overcome these challenges and improve the efficacy of CAR-T cells.

BLOOD CANCER JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Formulation of Nanovaccines toward an Extended Immunity against Nicotine

Yun Hu et al.

Summary: Nicotine vaccines have been studied for smoking cessation, and the combination of lipid-PLA and lipid-PLGA nanoparticles has shown potential for achieving long-lasting immunity against nicotine. The results suggest that the stability and combination of vaccines play a crucial role in their long-term efficacy, with the lipid-PLA vaccine inducing more sustained antibody production. Additionally, the study indicated that the vaccines were safe for use in mice based on body weight and histopathology assessments.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Engineered exosome-like nanovesicles suppress tumor growth by reprogramming tumor microenvironment and promoting tumor ferroptosis

Shichuan Hu et al.

Summary: In this study, fibroblast activation protein-alpha (FAP) gene-engineered tumor cell-derived exosome-like vesicle vaccines (eNVs-FAP) were developed as a candidate tumor vaccine targeting both the tumor parenchyma and the stroma. The eNVs-FAP vaccine showed excellent antitumor effects by inducing strong and specific CTL immune responses against tumor cells and FAP +CAFs, and reprogramming the immunosuppressive TME in various cancer models. The mechanistic analysis revealed that eNVs-FAP promoted DC maturation, increased effector T cell infiltration, and reduced immunosuppressive cell populations in the TME, leading to enhanced tumor cell ferroptosis.

ACTA BIOMATERIALIA (2021)

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Article Chemistry, Multidisciplinary

Nanovaccine-Mediated Cell Selective Delivery of Neoantigens Potentiating Adoptive Dendritic Cell Transfer for Personalized Immunization

Ping Xiao et al.

Summary: The combination of neoantigen-loaded nanovaccines and adoptive dendritic cell transfer enhances personalized immunity by facilitating immune cell access to lymph nodes and inhibiting tumor growth.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Multidisciplinary

Harnessing Innate Immunity Using Biomaterials for Cancer Immunotherapy

DaeYong Lee et al.

Summary: The discovery of immune checkpoint blockade has revolutionized cancer treatment, but current immunotherapies are only effective for a small subset of patients. Future advancements in cancer immunotherapy will focus on developing novel therapeutic molecules or immunoengineered cells. Biomaterials can efficiently reprogram and recruit immune cells in tumors to activate T cell immunity against advanced cancers.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery

Tiantian Song et al.

Summary: A major challenge in vaccine delivery lies in achieving robust lymph-node accumulation for stimulating adaptive immune responses. The deformability of albumin-stabilized emulsions allows for direct transfer to lymph nodes through cellular and intracellular pathways, enhancing antigen accumulation and immune response activation. Compared to solid particles, these droplets show increased efficiency in lymph node targeting and vaccination enhancement.

ADVANCED MATERIALS (2021)

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Review Chemistry, Multidisciplinary

From Design to Clinic: Engineered Nanobiomaterials for Immune Normalization Therapy of Cancer

Madiha Saeed et al.

Summary: This article discusses how nanotechnology-based methods can promote anti-tumor immune responses, with a focus on the importance of normalizing the tumor immune microenvironment. By targeting immunosuppressive cells and signaling pathways, nanomedicine has the potential to enhance the impact of cancer immunotherapy.

ADVANCED MATERIALS (2021)

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Review Medicine, Research & Experimental

Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis - A review

Pragya Prasanna et al.

Summary: Leishmaniasis, a tropical disease, is the second-largest infectious disease after malaria, but has not received much attention in research. The use of nanoparticles as anti-leishmanial agents offers high biocompatibility and improved therapeutic efficacy.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Oncology

Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non-Small Cell Lung Cancer

Angelo Porciuncula et al.

Summary: OX40 pathway is expressed in a fraction of NSCLCs and associated with favorable immune contexture. OX40L, although uncommonly expressed, is associated with better prognosis and can be introduced using exogenous mRNA.

CLINICAL CANCER RESEARCH (2021)

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Article Immunology

Nanovaccine: an emerging strategy

Amrita Das et al.

Summary: Nanovaccines, as efficient vaccine delivery systems, show great potential in improving tissue targeting, antigen presentation, and targeted delivery, providing promising strategies to combat infectious diseases and cancer.

EXPERT REVIEW OF VACCINES (2021)

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Review Nanoscience & Nanotechnology

CpG-Based Nanovaccines for Cancer Immunotherapy

Wenqiang Chen et al.

Summary: Nanoparticles used as carriers and/or adjuvants in tumor vaccines have shown significant therapeutic effects in cancer treatment. CpG ODN, a commonly used immune stimulant, can activate humoral and cellular immunity through Toll-like receptor 9 for cancer prevention or treatment.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Chemistry, Multidisciplinary

Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy

Min Li et al.

Summary: The study demonstrates that the use of photothermal therapy can enhance the antitumor ability of adoptively transferred NKT cells, leading to excellent growth inhibition of local tumors and efficient rejection of distant tumors. It also triggers long-term immunological memory to prevent tumor recurrence, showing promising potential for cancer immunotherapy.

NANO LETTERS (2021)

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Article Chemistry, Multidisciplinary

Personalized Nanovaccine Coated with Calcinetin-Expressed Cancer Cell Membrane Antigen for Cancer Immunotherapy

Xiang Xiong et al.

Summary: A novel nanovaccine containing a cell membrane antigen induced by immunogenic cell death was reported, providing a complete antigen array and avoiding severe chemotherapy toxicity. The nanovaccine codelivers adjuvant R837 and membrane antigen, triggering personalized immune responses, enhancing antitumor effects, and providing long-term protection. The surface-exposed calcinetin on the nanovaccine actively uptakes dendritic cells, enhancing antitumor effects, and activating immune memory cells.

NANO LETTERS (2021)

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Article Cell Biology

Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

Long Chen et al.

Summary: Utilizing Escherichia coli cytoplasmic membranes as adjuvants, a vaccine based on hybrid membrane nanoparticles containing tumor cell membranes induced sufficient antitumor reactivity without notable adverse effects, showing efficacy in various tumor mouse models and providing long-term protection against tumor rechallenge.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

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Review Engineering, Biomedical

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Muyue Yang et al.

Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.

BIOACTIVE MATERIALS (2021)

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Article Medicine, Research & Experimental

EFFICACY OF PEGYLATED LIPOSOMAL DOXORUBICIN-BASED NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER: A SINGLE CENTER EXPERIENCE

I-Chen Tsai et al.

Summary: The study suggests that neoadjuvant chemotherapy using polyethylene glycol-coated liposomal doxorubicin might be beneficial for non-metastatic operable breast cancer in Taiwanese females, especially for those with clinically negative lymph nodes and HER2-enriched patients. Patients who achieved pathologic complete response had a better prognosis outcome, and the recurrence rate was lower in the pCR group compared to the non-pCR group during a median follow-up of 11.63 months.

CLINICAL AND INVESTIGATIVE MEDICINE (2021)

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Review Oncology

The Changing Landscape of Therapeutic Cancer Vaccines-Novel Platforms and Neoantigen Identification

Jessica Jou et al.

Summary: Therapeutic cancer vaccines aim to create and enhance tumor-specific T-cell responses, but face challenges in achieving success. Researchers are exploring various strategies to overcome immunosuppressive mechanisms in the tumor microenvironment, improve vaccine delivery platforms, and utilize combination therapies.

CLINICAL CANCER RESEARCH (2021)

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Article Materials Science, Biomaterials

A simple self-adjuvanting biomimetic nanovaccine self-assembled with the conjugate of phospholipids and nucleotides can induce a strong cancer immunotherapeutic effect

Dan Liu et al.

Summary: The study developed a self-adjuvanting biomimetic anti-tumor nanovaccine, which effectively stimulated antigen responses, provided sustained antigen supply, induced CD8(+) T-cell responses, and showed significant anti-tumor effects and survival prolongation. This nanovaccine self-assembled with phospholipid-nucleotide amphiphiles offers a safe, simple, and efficient approach for anti-tumor immunotherapy.

BIOMATERIALS SCIENCE (2021)

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Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

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Article Chemistry, Multidisciplinary

Biomimetic Nanotechnology toward Personalized Vaccines

Jiarong Zhou et al.

ADVANCED MATERIALS (2020)

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Review Immunology

β-glucan as a new tool in vaccine development

Vaclav Vetvicka et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2020)

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Article Chemistry, Multidisciplinary

A Hybrid Eukaryotic-Prokaryotic Nanoplatform with Photothermal Modality for Enhanced Antitumor Vaccination

Qi Chen et al.

ADVANCED MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Synthesis of Poly(acyclic orthoester)s: Acid-Sensitive Biomaterials for Enhancing Immune Responses of Protein Vaccine

Yumeng Xing et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Engineering, Biomedical

E-jet 3D printed drug delivery implants to inhibit growth and metastasis of orthotopic breast cancer

Yikun Yang et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Engineering ApoE3-incorporated biomimetic nanoparticle for efficient vaccine delivery to dendritic cells via macropinocytosis to enhance cancer immunotherapy

Songlei Zhou et al.

BIOMATERIALS (2020)

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Review Oncology

Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy

Xu Lei et al.

CANCER LETTERS (2020)

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Editorial Material Oncology

Building on the Promise of Cancer Vaccines for Solid Tumors

Craig L. Slingluff

CLINICAL CANCER RESEARCH (2020)

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Review Immunology

Top 10 Challenges in Cancer Immunotherapy

Priti S. Hegde et al.

IMMUNITY (2020)

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Review Chemistry, Multidisciplinary

Current challenges and emerging opportunities of CAR-T cell therapies

Teresa R. Abreu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

John D. Martin et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

Katharina Reinhard et al.

SCIENCE (2020)

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Article Cell Biology

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

Jesse M. Jaynes et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Immunology

T Cell Co-stimulation and Functional Modulation by Innate Signals

Takayuki Imanishi et al.

TRENDS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Clonal kinetics and single-cell transcriptional profiling of CAR-T cells in patients undergoing CD19 CAR-T immunotherapy

Alyssa Sheih et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Immunoproteasome expression is associated with better prognosis and response to checkpoint therapies in melanoma

Shelly Kalaora et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

Poly(amino acids) as a potent self-adjuvanting delivery system for peptide-based nanovaccines

Mariusz Skwarczynski et al.

SCIENCE ADVANCES (2020)

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Review Pharmacology & Pharmacy

Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies

Michael Lim et al.

PHARMACEUTICS (2020)

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Review Chemistry, Multidisciplinary

Nanoengineered targeting strategy for cancer immunotherapy

Wei-min Yin et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Article Chemistry, Multidisciplinary

Sequential and Timely Combination of a Cancer Nanovaccine with Immune Checkpoint Blockade Effectively Inhibits Tumor Growth and Relapse

Yujin Kim et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Multidisciplinary

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer

Shanshan Cheng et al.

ADVANCED SCIENCE (2020)

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Review Immunology

Characteristics of Tumor-Infiltrating Lymphocytes Prior to and During Immune Checkpoint Inhibitor Therapy

Ioana Plesca et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Pharmacology & Pharmacy

Multi-functional nanocomplex codelivery of Trp2 and R837 to activate melanoma-specific immunity

Zhonghua Ji et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Article Nanoscience & Nanotechnology

Selective Tumor-Specific Antigen Delivery to Dendritic Cells Using Mannose-Labeled Poly(d,l-lactide-co-glycolide) Nanoparticles for Cancer Immunotherapy

Tae In Wi et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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Review Medicine, Research & Experimental

Immune escape and immunotherapy of acute myeloid leukemia

Luca Vago et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Review Pharmacology & Pharmacy

Resistance to PD-L1/PD-1 Blockade Immunotherapy. A Tumor-Intrinsic or Tumor-Extrinsic Phenomenon?

Luisa Chocarro de Erauso et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Immunology

MR1-Restricted T Cells Are Unprecedented Cancer Fighters

Alessandro Vacchini et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

Qianqian Ni et al.

SCIENCE ADVANCES (2020)

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Article Chemistry, Multidisciplinary

Engineering Polymeric Prodrug Nanoplatform for Vaccination Immunotherapy of Cancer

Lei Zhou et al.

NANO LETTERS (2020)

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Review Oncology

Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines

Anna Lucia Tornesello et al.

CANCERS (2020)

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Article Chemistry, Physical

Metabolic labeling and targeted modulation of dendritic cells

Hua Wang et al.

NATURE MATERIALS (2020)

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Article Chemistry, Multidisciplinary

Co-delivery of Peptide Neoantigens and Stimulator of Interferon Genes Agonists Enhances Response to Cancer Vaccines

Daniel Shae et al.

ACS NANO (2020)

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Article Biochemical Research Methods

Biotinylated Streptavidin Surface Coating Improves the Efficacy of a PLGA Microparticle-Based Cancer Vaccine

Brett P. Gross et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Oncology

A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases

Yanina Jansen et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Biotechnology & Applied Microbiology

Lipidation Approaches Potentiate Adjuvant-Pulsed Immune Surveillance: A Design Rationale for Cancer Nanovaccine

Junqing Wang et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Cell Biology

Breakthrough concepts in immune-oncology: Cancer vaccines at the bedside

Sohini Roy et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Review Oncology

Development of CAR-T cell therapies for multiple myeloma

Nico Gagelmann et al.

LEUKEMIA (2020)

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Article Engineering, Biomedical

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

Flavia Castro et al.

BIOMATERIALS (2020)

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Article Engineering, Biomedical

Synergistic tumor immunological strategy by combining tumor nanovaccine with gene-mediated extracellular matrix scavenger

Yingying Hu et al.

BIOMATERIALS (2020)

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Article Cell Biology

Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy

Xueguang Lu et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Review Oncology

The efficacy and safety of combined immune checkpoint inhibitors (nivolumab plus ipilimumab): a systematic review and meta-analysis

Jingjie Chen et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2020)

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Article Chemistry, Multidisciplinary

Cancer Immunotherapy via Targeting Cancer Stem Cells Using Vaccine Nanodiscs

Alireza Hassani Najafabadi et al.

NANO LETTERS (2020)

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Article Biotechnology & Applied Microbiology

Nanovaccine impact on dendritic cells: transcriptome analysis enables new insights into antigen and adjuvant effects

David Passlick et al.

NANOMEDICINE (2020)

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Article Immunology

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies

Shogo Kumagai et al.

NATURE IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas

Qing Deng et al.

NATURE MEDICINE (2020)

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Article Nanoscience & Nanotechnology

Proton-driven transformable nanovaccine for cancer immunotherapy

Ningqiang Gong et al.

NATURE NANOTECHNOLOGY (2020)

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Article Cell Biology

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

Xiaozhe Yin et al.

CELL REPORTS (2020)

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Article Chemistry, Multidisciplinary

Choice of Nanovaccine Delivery Mode Has Profound Impacts on the Intralymph Node Spatiotemporal Distribution and Immunotherapy Efficacy

Jianghua Wang et al.

ADVANCED SCIENCE (2020)

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Article Immunology

Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice

Jing Huang et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Oncology

Point mutation inCD19facilitates immune escape of B cell lymphoma from CAR-T cell therapy

Zhen Zhang et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Review Biochemical Research Methods

Engineering nanoparticulate vaccines for enhancing antigen cross-presentation

Guangsheng Du et al.

CURRENT OPINION IN BIOTECHNOLOGY (2020)

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Article Medicine, General & Internal

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies

Reuben Benjamin et al.

LANCET (2020)

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Review Chemistry, Multidisciplinary

Metabolic glycan labelling for cancer-targeted therapy

Hua Wang et al.

NATURE CHEMISTRY (2020)

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Article Multidisciplinary Sciences

Size-transformable antigen-presenting cell-mimicking nanovesicles potentiate effective cancer immunotherapy

Weijing Yang et al.

SCIENCE ADVANCES (2020)

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Article Nanoscience & Nanotechnology

A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy

Jun Xu et al.

NATURE NANOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Lydia Kalafati et al.

CELL (2020)

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Review Chemistry, Multidisciplinary

Nanoparticle formulated vaccines: opportunities and challenges

Pingsai Lung et al.

NANOSCALE (2020)

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Article Plant Sciences

Augmented cytotoxic effects of paclitaxel by curcumin induced overexpression of folate receptor-α for enhanced targeted drug delivery in HeLa cells

Sugapriya Dhanasekaran

PHYTOMEDICINE (2019)

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Article Urology & Nephrology

Primary Results from SAUL, a Multinational Single-arm Safety Study of Atezolizumab Therapy for Locally Advanced or Metastatic Urothelial or Nonurothelial Carcinoma of the Urinary Tract

Cora N. Sternberg et al.

EUROPEAN UROLOGY (2019)

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Article Pharmacology & Pharmacy

Optimization of peptide-based cancer vaccine compositions, by sequential screening, using versatile liposomal platform

Celia Jacoberger-Foissac et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Biochemistry & Molecular Biology

The vaccine adjuvant MPLA activates glycolytic metabolism in mouse mDC by a JNK-dependent activation of mTOR-signaling

Frank Blanco-Perez et al.

MOLECULAR IMMUNOLOGY (2019)

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Article Chemistry, Multidisciplinary

Targeted Codelivery of an Antigen and Dual Agonists by Hybrid Nanoparticles for Enhanced Cancer Immunotherapy

Linhua Zhang et al.

NANO LETTERS (2019)

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Article Multidisciplinary Sciences

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

Mohamad Hamieh et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Neoantigen-directed immune escape in lung cancer evolution

Rachel Rosenthal et al.

NATURE (2019)

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Article Chemistry, Multidisciplinary

Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment

Linnan Yang et al.

ADVANCED SCIENCE (2019)

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Review Pharmacology & Pharmacy

Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine

Nathan D. Donahue et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Biochemical Research Methods

Chondroitin Sulfate-Based pH-Sensitive Polymer-Modified Liposomes for Intracellular Antigen Delivery and Induction of Cancer Immunity

Minori Okubo et al.

BIOCONJUGATE CHEMISTRY (2019)

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Article Medicine, Research & Experimental

CD19 CAR T cell product and disease attributes predict leukemia remission durability

Olivia C. Finney et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Chemistry, Multidisciplinary

Synergistic STING activation by PC7A nanovaccine and ionizing radiation improves cancer immunotherapy

Min Luo et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Biochemistry & Molecular Biology

Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment

Ming Yi et al.

MOLECULAR CANCER (2019)

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Article Biochemistry & Molecular Biology

A safe and potent anti-CD19 CAR T cell therapy

Zhitao Ying et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Gene-edited stem cells enable CD33-directed immune therapy for myeloid malignancies

Florence Borot et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Chemistry, Multidisciplinary

The Nano-Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions

Yaling Wang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Oncology

Managing the toxicities of CAR T-cell therapy

Sattva S. Neelapu

HEMATOLOGICAL ONCOLOGY (2019)

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Review Biochemistry & Molecular Biology

Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic

Anne Geller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Multidisciplinary Sciences

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Anna M. Paczulla et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells

Wen-Long Liu et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Wei Li et al.

NATURE COMMUNICATIONS (2019)

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Article Immunology

Regulation of Tolerogenic Features on Dexamethasone-Modulated MPLA-Activated Dendritic Cells by MYC

Paulina A. Garcia-Gonzalez et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

T Cell Dysfunction in Cancer Immunity and Immunotherapy

Anliang Xia et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Chemistry, Multidisciplinary

Survey of Clinical Translation of Cancer Nanomedicines-Lessons Learned from Successes and Failures

Hongliang He et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Multiantigenic Nanoformulations Activate Anticancer Immunity Depending on Size

Shengxian Li et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

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Review Chemistry, Multidisciplinary

Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis

Pengcheng Zhang et al.

ADVANCED MATERIALS (2019)

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Article Oncology

Induction of anti-cancer T cell immunity by in situ vaccination using systemically administered nanomedicines

Geoffrey M. Lynn et al.

CANCER LETTERS (2019)

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Article Chemistry, Multidisciplinary

Targeting Heterogeneous Tumors Using a Multifunctional Molecular Prodrug

Amit Sharma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Article Nanoscience & Nanotechnology

Immunization with mannosylated nanovaccines and inhibition of the immune-suppressing microenvironment sensitizes melanoma to immune checkpoint modulators

Joao Conniot et al.

NATURE NANOTECHNOLOGY (2019)

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Article Engineering, Biomedical

In vivo cancer targeting via glycopolyester nanoparticle mediated metabolic cell labeling followed by click reaction

Hua Wang et al.

BIOMATERIALS (2019)

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Review Biochemistry & Molecular Biology

Engineering anti-cancer nanovaccine based on antigen cross-presentation

Vaishnavi U. Warrier et al.

BIOSCIENCE REPORTS (2019)

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Article Medicine, Research & Experimental

Rational Design of PLGA Nanoparticle Vaccine Delivery Systems To Improve Immune Responses

Pengfei Gu et al.

MOLECULAR PHARMACEUTICS (2019)

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Review Engineering, Biomedical

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Wen Liao et al.

ACTA BIOMATERIALIA (2019)

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Review Oncology

Tumor Endothelial Heterogeneity in Cancer Progression

Nako Maishi et al.

CANCERS (2019)

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Review Oncology

Cancer Cell Membrane-Coated Nanoparticles for Cancer Management

Jenna C. Harris et al.

CANCERS (2019)

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Review Pharmacology & Pharmacy

Recent Advances in Nanovaccines Using Biomimetic Immunomodulatory Materials

Veena Vijayan et al.

PHARMACEUTICS (2019)

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Review Pharmacology & Pharmacy

The Role of Nanovaccine in Cross-Presentation of Antigen-Presenting Cells for the Activation of CD8+ T Cell Responses

Cheol Gyun Kim et al.

PHARMACEUTICS (2019)

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Article Oncology

Tumor-Infiltrating T Cell Receptor-Beta Repertoires are Linked to the Risk of Late Chemoradiation-Induced Temporal Lobe Necrosis in Locally Advanced Nasopharyngeal Carcinoma

LiFu Wu et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2019)

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Review Cell Biology

Nanovaccine: A novel approach in immunization

Seyed Mohammad Gheibi Hayat et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Medicine, Research & Experimental

Effective NY-ESO-1 specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression

Lucia Poncette et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Nanoscience & Nanotechnology

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Qian Chen et al.

NATURE NANOTECHNOLOGY (2019)

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Article Engineering, Biomedical

Tumor Lysate-Loaded Lipid Hybrid Nanovaccine Collaborated with an Immune Checkpoint Antagonist for Combination Immunotherapy

Xiaomeng Hu et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

Chu-Xin Li et al.

ADVANCED MATERIALS (2019)

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Article Chemistry, Multidisciplinary

Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy

Hathaichanok Phuengkham et al.

ADVANCED MATERIALS (2019)

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Article Multidisciplinary Sciences

Artificially cloaked viral nanovaccine for cancer immunotherapy

Manlio Fusciello et al.

NATURE COMMUNICATIONS (2019)

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Review Materials Science, Biomaterials

Recent progress in nanomaterials for nucleic acid delivery in cancer immunotherapy

Yeling Mei et al.

BIOMATERIALS SCIENCE (2019)

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Article Multidisciplinary Sciences

Enhanced CAR-T cell activity against solid tumors by vaccine boosting through the chimeric receptor

Leyuan Ma et al.

SCIENCE (2019)

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Review Materials Science, Biomaterials

Hybrid lipid-nanoparticle complexes for biomedical applications

Kevin M. Vargas et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

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Review Chemistry, Multidisciplinary

Organic-inorganic nanoflowers: from design strategy to biomedical applications

Yucheng Liu et al.

NANOSCALE (2019)

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Article Materials Science, Biomaterials

Biomimetic Nanoparticle Vaccines for Cancer Therapy

Ashley Kroll et al.

ADVANCED BIOSYSTEMS (2019)

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Article Materials Science, Biomaterials

A cell-penetrating peptide-assisted nanovaccine promotes antigen cross-presentation and anti-tumor immune response

Xiaoxuan Liu et al.

BIOMATERIALS SCIENCE (2019)

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Review Immunology

NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer Treatment

Alexandra Frazao et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Medicine, Research & Experimental

Nanoparticle Delivery of Immunostimulatory Agents for Cancer Immunotherapy

Jia Zhuang et al.

THERANOSTICS (2019)

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Article Chemistry, Multidisciplinary

Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination

Rong Yang et al.

ACS NANO (2018)

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Article Chemistry, Multidisciplinary

Antigen-Directed Fabrication of a Multifunctional Nanovaccine with Ultrahigh Antigen Loading Efficiency for Tumor Photothermal-Immunotherapy

Jinbin Pan et al.

ADVANCED MATERIALS (2018)

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Article Engineering, Biomedical

Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy

Ling-xiao Zhang et al.

BIOMATERIALS (2018)

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Article Biochemistry & Molecular Biology

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

Miriam Y. Kim et al.

CELL (2018)

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Review Oncology

Novel Approaches to Acute Myeloid Leukemia Immunotherapy

Ofrat Beyar-Katz et al.

CLINICAL CANCER RESEARCH (2018)

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Article Biophysics

The effects of ligand valency and density on the targeting ability of multivalent nanoparticles based on negatively charged chitosan nanoparticles

Jing Cao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Review Pharmacology & Pharmacy

Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics

Rajendran J. C. Bose et al.

DRUG DISCOVERY TODAY (2018)

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Editorial Material Chemistry, Multidisciplinary

Combined therapy of imatinib and an anti-CTLA4 immune-checkpoint inhibitor

Kinam Park

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Chemistry, Multidisciplinary

Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor a expression induced by dexamethasone and valproic acid

E. Peraudeau et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Oncology

The perfect personalized cancer therapy: cancer vaccines against neoantigens

Luigi Aurisicchio et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Review Oncology

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

Jian Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Article Chemistry, Multidisciplinary

Endolysosomal-Escape Nanovaccines through Adjuvant-Induced Tumor Antigen Assembly for Enhanced Effector CD8(+) T Cell Activation

Liping Qiu et al.

SMALL (2018)

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Review Immunology

Improving Vaccine and Immunotherapy Design Using Biomaterials

Michelle L. Bookstaver et al.

TRENDS IN IMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Tomer Cooks et al.

NATURE COMMUNICATIONS (2018)

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Article Engineering, Biomedical

Mannose and Mannose-6-Phosphate Receptor-Targeted Drug Delivery Systems and Their Application in Cancer Therapy

Elena Dalle Vedove et al.

ADVANCED HEALTHCARE MATERIALS (2018)

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