Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 57, Issue 12, Pages 1941-1944Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.116.178673
Keywords
PSMA; (225)AC; alpha-therapy
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Prostate-specific membrane antigen (PSMA) is a promising target in prostate cancer. Recently, we started the first-in-human treatment with an a-radionuclide labeled PSMA ligand. Although the case series is still ongoing, we here report in advance about two patients in highly challenging clinical situations who showed a complete response to (225)AcPSMA-617 therapy. Methods: Ga-68-PSMA-11 PET/CT validated the presence of the PSMA-positive tumor phenotype. A 100-kBq activity of Ac-228-PSMA-617 per kilogram of body weight was administered bimonthly. Prostate-specific antigen response and hematologic toxicity were measured at least every 4 wk. Restaging was performed with Ga-68-PSMA-11 PET/CT. Results: Both patients experienced a prostate specific antigen decline to below the measurable level and showed a complete response on imaging. No relevant hematologic toxicity was observed. Xerostomia was the only mentionable clinical side effect. Conclusion: Targeted a-therapy with Ac-225-PSMA-617, although still experimental, obviously has strong potential to significantly benefit advanced-stage prostate cancer patients.
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