Journal
ADVANCED MATERIALS
Volume 27, Issue 39, Pages 6034-6038Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502814
Keywords
biosensors; locked nucleic acids; nanoparticles; single cells; tissue microenvironments
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Funding
- National Institutes of Health (NIH) [1DP2OD007161-01]
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD007161] Funding Source: NIH RePORTER
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A gold nanorod-locked nucleic acid nano biosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.
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