4.8 Article

Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments

Journal

ADVANCED MATERIALS
Volume 27, Issue 39, Pages 6034-6038

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502814

Keywords

biosensors; locked nucleic acids; nanoparticles; single cells; tissue microenvironments

Funding

  1. National Institutes of Health (NIH) [1DP2OD007161-01]
  2. OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [DP2OD007161] Funding Source: NIH RePORTER

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A gold nanorod-locked nucleic acid nano biosensor for dynamic single-cell gene expression analysis in living cells and tissues is developed. The nanoparticle facilitates endocytic delivery and dynamic monitoring of the gene expression in human umbilical cord endothelial cells, mouse skin tissues, mouse retina tissues, and mouse cornea tissues at the single-cell level.

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