Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 57, Issue 11, Pages 1764-1770Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.115.157438
Keywords
lung inflammation; pulmonary; molecular imaging; positron emission tomography
Funding
- NIH [R01 HL121218]
- Pfizer, Inc.
- Washington University School of Medicine Institute of Clinical and Translational Sciences
- Mallinckrodt Institute of Radiology
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Lung inflammatory diseases contribute significantly to the socioeconomic burden of disease. Yet very few new, effective therapies for respiratory disease have been approved for use. A major contributing factor is the lack of biomarkers that can accurately quantify the lung inflammatory burden and can be used to understand the contribution of lung inflammation to loss in lung function. Molecular imaging approaches can detect and quantify the recruitment and activation of specific immune cells in lung inflammation. We review the clinical techniques used to image lung inflammation, provide an overview of clinical and emerging PET techniques for quantifying lung inflammation, and discuss potential clinical applications.
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