Tailoring MOFs to Biomedical Applications: A Chimera or a Concrete Reality? The Case Study of Fe-BTC by bio-friendly Mechanosynthesis

We point-out an exceptional tailorability of iron(III) trimesate metal organic framework to bio-friendly conditions. This is particularly attractive in sight of one-pot immobilization of biomolecules for biomedical applications. Synthesis is carried out via mechanochemical approach under green, biocompatible conditions without additional solvents, in just 1 hour, at room temperature. Solvents are proven to be unnecessary to build the framework, in contrast to solution-based methods. Microstructure and thermal stability of the material are not affected by pH. Conversely, textural can be tuned the amount of base.

Automated summary

This study reveals the exceptional tailorability of iron(III) trimesate metal organic framework under bio-friendly conditions for the one-pot immobilization of biomolecules for biomedical applications. The framework is synthesized via a solvent-free mechanochemical approach in just 1 hour at room temperature. In contrast to solution-based methods, solvents are unnecessary for framework construction. The microstructure and thermal stability of the material are unaffected by pH, while the texture can be tuned by adjusting the base amount.