4.7 Article

A bifunctional zoledronate sustained-release system in scaffold: Tumor therapy and bone repair

Related references

Note: Only part of the references are listed.
Article Cell Biology

Substrate stiffness regulates the differentiation profile and functions of osteoclasts via cytoskeletal arrangement

Qingxuan Wang et al.

Summary: The stiffness of the substrate plays a crucial role in osteoclast differentiation and function, with higher stiffness accelerating osteoclast formation and activity. Higher stiffness substrates can also activate cytoskeletal adhesion molecules and biochemical signaling cascades.

CELL PROLIFERATION (2022)

Article Oncology

Vδ2 T cells are associated with favorable clinical outcomes in patients with bladder cancer and their tumor reactivity can be boosted by BCG and zoledronate treatments

Sylvain Nguyen et al.

Summary: The proportion of gamma delta T cells, especially V delta 2 T cells, is associated with patient survival in bladder cancer. These findings suggest the potential role of V delta 2 T cells in bladder tumor control.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Article Engineering, Biomedical

Accelerated degradation of HAP/PLLA bone scaffold by PGA blending facilitates bioactivity and osteoconductivity

Cijun Shuai et al.

Summary: The addition of PGA into HAP/PLLA scaffold accelerated the degradation process, leading to increased degradation rate and pore formation, which promoted the deposition and growth of bone-like apatite as well as provided a favorable environment for osteoblast adhesion and proliferation. This led to excellent bone defect repair capacity demonstrated by the formation of abundant new bone tissue and blood vessel tissue, ultimately bridging both ends of the defect region after 8 weeks of implantation.

BIOACTIVE MATERIALS (2021)

Article Cell Biology

The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

Igor L. Bado et al.

Summary: Estrogen receptor-positive (ER+) breast cancer shows strong bone tropism in metastasis, with the bone microenvironment impacting ER signaling and endocrine therapy. The osteogenic niche transiently reduces ER expression and activities specifically in bone micrometastases, leading to endocrine resistance. EZH2-mediated epigenomic reprogramming drives ER+ BMMs towards a basal and stem-like state, and EZH2 inhibition reverses endocrine resistance.

DEVELOPMENTAL CELL (2021)

Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Cell & Tissue Engineering

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Jinfeng Liao et al.

Summary: Bone tumors, especially osteosarcoma, present challenges in treatment as surgical resection often fails to completely remove the tumor, leading to high mortality rates. Recent developments in bifunctional biomaterials, such as hydrogels and 3D-printed scaffolds, offer potential new strategies for tumor therapy and bone regeneration.

BONE RESEARCH (2021)

Editorial Material Medicine, General & Internal

Tumor Microenvironment, Metabolism, and Immunotherapy

Ralph J. DeBerardinis

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma

Ko-Hsiu Lu et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Article Engineering, Environmental

Antibacterial polymer scaffold based on mesoporous bioactive glass loaded with in situ grown silver

Cijun Shuai et al.

CHEMICAL ENGINEERING JOURNAL (2019)

Article Cell Biology

Evaluation of efficacy on RANKL induced osteoclast from RAW264.7 cells

Chengchao Song et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Materials Science, Ceramics

Mesoporous silica SBA-16/hydroxyapatite-based composite for ciprofloxacin delivery to bacterial bone infection

Gracielle Ferreira Andrade et al.

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY (2018)

Article Cell & Tissue Engineering

Calcium Sulphate/Hydroxyapatite Carrier for Bone Formation in the Femoral Neck of Osteoporotic Rats

Aurimas Sirka et al.

TISSUE ENGINEERING PART A (2018)

Article Chemistry, Multidisciplinary

A Multimaterial Scaffold With Tunable Properties: Toward Bone Tissue Repair

Pei Feng et al.

ADVANCED SCIENCE (2018)

Article Biochemistry & Molecular Biology

Effects of methylglyoxal on RANKL-induced osteoclast differentiation in RAW264.7 cells

Kwang Sik Suh et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2018)

Review Materials Science, Multidisciplinary

Tuning mesoporous silica dissolution in physiological environments: a review

Juan L. Paris et al.

JOURNAL OF MATERIALS SCIENCE (2017)

Editorial Material Cell Biology

Signalling to cell cycle arrest

Paulina Strzyz

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Materials Science, Multidisciplinary

Zoledronic acid impregnated and poly (L-lactic acid) coated 45S5 Bioglass®-based scaffolds

Janis Locs et al.

MATERIALS LETTERS (2015)

Article Dentistry, Oral Surgery & Medicine

Advances in the Regulation of Osteoclasts and Osteoclast Functions

B. F. Boyce

JOURNAL OF DENTAL RESEARCH (2013)

Review Chemistry, Multidisciplinary

Mesoporous silica nanoparticles in biomedical applications

Zongxi Li et al.

CHEMICAL SOCIETY REVIEWS (2012)

Review Medicine, General & Internal

Bone regeneration: current concepts and future directions

Rozalia Dimitriou et al.

BMC MEDICINE (2011)

Article Oncology

Osteosarcoma

J. Ritter et al.

ANNALS OF ONCOLOGY (2010)

Article Chemistry, Multidisciplinary

Evidence of drug confinement into silica mesoporous matrices by STEM spherical aberration corrected microscopy

Maria Vallet-Regi et al.

CHEMICAL COMMUNICATIONS (2010)

Article Orthopedics

Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy

Arbeitsgemeinschaft Knochentumoren

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2008)

Article Chemistry, Multidisciplinary

Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials

Francisco Balas et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

Review Multidisciplinary Sciences

Osteoclast differentiation and activation

WJ Boyle et al.

NATURE (2003)