Related references
Note: Only part of the references are listed.
Article
Chemistry, Multidisciplinary
Xiaoyu Huang et al.
Summary: A one-component layered nickel silicate nanoplatform has been successfully synthesized, which can supply oxygen and generate superoxide radicals under near-infrared irradiation. This novel nanoplatform overcomes the obstacles of oxygen consumption and hypoxic tumor environment in photodynamic therapy.
Article
Chemistry, Multidisciplinary
Qianli Ma et al.
Summary: This review summarizes the recent progress of various DPP-based organic small molecules in the field of phototheranostics over the last five years. The molecular structure design and their phototheranostics performances are discussed in detail, providing valuable references for the further development of DPP-based phototheranostics.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Shaoqi Guan et al.
Summary: An intelligent biodegradable nanocomposite, mZMD, has been developed to enhance sonodynamic therapy (SDT), chemodynamic therapy (CDT), and chemotherapy by promoting oxidative stress and overcoming multidrug resistance.
Article
Chemistry, Multidisciplinary
Jinyan Lin et al.
Summary: A virus-mimicking nanogenerator is designed for synergistic thermodynamic-chemodynamic therapy, encapsulating AIPH precursor and cloaked with NK cell membrane for enhanced tumor accumulation. The nanogenerator can be activated by NIR and GSH to generate radicals for oxidative stress-based anticancer therapy.
Article
Engineering, Biomedical
JunJie Tang et al.
Summary: This study presents a novel oxygen-independent, ROS-amplifying chemo-sonodynamic antitumor therapy using pH/GSH/ROS triple-responsive PEG-PPMDT nanoparticles. The therapy effectively releases drugs and amplifies ROS levels in tumor cells, leading to significant tumor growth inhibition. The therapy also demonstrates minimal toxicity to main organs and can be guided by Fe(3)O(4) encapsulated in the nanoparticles.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Wandong Wang et al.
Summary: Hydrogen therapy is an emerging therapeutic strategy in anticancer medicine, but the challenges of stable hydrogen storage and efficient delivery hinder its development. In this study, a smart yolk-shell nanoplatform was designed to overcome these challenges and enhance the efficacy of photodynamic therapy through hydrogen release, increased reactive oxygen species generation, and ameliorated hypoxic conditions.
Article
Chemistry, Physical
Yang Wang et al.
Summary: In this study, a thermal-responsive glycol-targeting nitric oxide nanogenerator was constructed by covalently conjugating thermal-responsive nitrosothiols on the surface of mesoporous silica-coated gold nanorods, then coating it with a supramolecular complex, and finally loading an alkyl radical initiator. The nanogenerator showed specific targeting ability to HepG2 cells and generated hyperthermia under near infrared irradiation, resulting in photothermal therapy as well as gas therapy and alkyl radical therapy. In vitro experiments demonstrated its biocompatibility and effective inhibition of HepG2 cell proliferation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Hang Hu et al.
Summary: This study developed a multifunctional nanoplatform for enhanced cancer phototherapy using a relatively simple and effective strategy to potentiate photodynamic therapy (PDT). The nanoplatform overcame PDT resistance by providing oxygen, depleting intracellular glutathione (GSH), and targeting the tumor, resulting in enhanced PDT and photothermal therapy (PTT) effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Shuqi Jiang et al.
Summary: Chemotherapy plays a crucial role in cancer treatment, but hypoxia-mediated chemoresistance is a major challenge. In this study, a novel class of nanoparticles was developed to enhance glioma chemotherapy. These nanoparticles can release drugs and generate reactive oxygen species in the tumor microenvironment, effectively killing tumor cells. Additionally, the nanoparticles enable real-time tumor monitoring with magnetic resonance imaging.
Article
Nanoscience & Nanotechnology
Wenting Li et al.
Summary: This study developed functionalized PLGA-based nanocomposites for targeted treatment of hypoxic tumors through the generation of an oxygen-independent free-radical cascade combined with photothermal-induced thermodynamic therapy and macrophage polarization strategies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Ruihao Li et al.
Summary: This study successfully constructed a new multifunctional nanoplatform (M-17AAG-AIPH) for the treatment of TNBC through mild-temperature photothermal therapy and oxygen-independent cytotoxic free radicals.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Analytical
Zongsheng Wu et al.
Summary: Inorganic nanoprobes with versatile functionalities and excellent optical properties have gained increasing attention in the biomedical field. However, their limited retention time in tumors and application in the first near-infrared window (NIR-I) have hindered accurate and deep tissue imaging. To address this, researchers developed a Janus nanoprobe that can aggregate in the tumor microenvironment, prolonging retention time and enabling photoacoustic imaging in the second near-infrared window (NIR-II) as well as enhancing photodynamic therapy effects.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Haiyan Pan et al.
Summary: In this study, direct injection of potassium permanganate (KMnO4) into solid tumors was shown to enable in situ formation of manganese dioxide (MnO2) as an oxygen depot for cascade oxidation damage and enhanced photodynamic therapy. Using the KMnO4-ce6 system, excellent cascade tumor suppression effect was achieved without the need for synthesis processes.
Article
Engineering, Environmental
Peng Lin et al.
Summary: Researchers have developed an intelligent nanoplatform that can efficiently treat hypoxic tumors by persistently utilizing oxygen. The nanoplatform releases inhibitors and excess H2O2 to generate oxygen continuously, and enhances photodynamic therapy through the activation of a photosensitizer using X-ray irradiation. This method offers sustained and improved treatment for hypoxic tumors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Mengtong Xia et al.
Summary: A study combines nitric oxide (NO) therapy with photodynamic therapy (PDT) using a novel nanosystem to simultaneously reduce glutathione (GSH) content and relieve hypoxia, enhancing the production of reactive oxygen species (ROS) and the efficacy of PDT.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Environmental
Ying Yang et al.
Summary: A novel nanoplatform was designed to overcome the limitations of reactive oxygen species (ROS) mediated therapies in the complex tumor microenvironment (TME). The nanoplatform utilized and improved the TME to achieve effective antitumor effects, including photothermal therapy (PTT), photodynamic therapy (PDT), and photothermal imaging. Through multiple regulation of the TME, the nanoplatform enhanced the production of ROS and reduced the antioxidant capacity of the tumor, leading to improved therapeutic outcomes.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Jianqin Yan et al.
Summary: This study presents a smart multistage Trojan Horse-inspired BSA-coated liposome for enhancing tumor penetration and antitumor efficacy. The results show that the liposome effectively penetrates into tumor cells and exhibits the strongest tumor penetration and cytotoxicity.
Article
Engineering, Environmental
Limin Wang et al.
Summary: In this paper, simple nitrated carbon dots (CDs-NO) were synthesized as a nanoparticle that combines gas therapy and phototherapy therapy. Under near-infrared irradiation, the generated ROS combines with NO to form highly cytotoxic radicals, effectively inhibiting cancer cells. The synergistic NO therapy and photothermal/dynamic therapy not only have a significant therapeutic effect on tumor-bearing mice but also efficiently inhibit metastasis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Mei Wen et al.
Summary: Integrated theranostic nanoplatforms with multi-modal imaging and therapeutic functions have been developed for cancer treatments. This study reports the design and preparation of hemoporfin@Cu9S8@MnO2 nanoparticles (H@Cu9S8@MnO2 NPs) for magnetic resonance imaging-guided catalytically-assisted photothermal-sonodynamic therapies of tumors. The nanoparticles exhibit enhanced photoabsorption in the near-infrared region and have the ability to trigger the decomposition of endogenous H2O2 and promote the production of reactive oxygen species. In vivo experiments demonstrate superior therapeutic effects compared to mono-model therapy alone.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Materials Science, Multidisciplinary
Xuehua Long et al.
Summary: Autophagy plays a dual role in tumorigenesis as a tumor suppressor or promoter, depending on the tumor microenvironment. Nanoparticles have shown promising potential in overcoming limitations and are a viable option for cancer treatment.
NPG ASIA MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Qian Wang et al.
Summary: This study presents a versatile nanoplatform that can regulate the level of reactive oxygen species (ROS) in the tumor microenvironment (TME). By depleting GSH and decomposing H2O2, the nanoplatform enhances the therapeutic efficacy of photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT).
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Yilin Wan et al.
Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yushan Dong et al.
Summary: In this study, ultrathin 2D Bi2MoO6-poly(ethylene glycol) nanoribbons were designed as piezoelectric sonosensitizers for sonodynamic therapy (SDT), aiming to reduce the scavenging capacity of reactive oxygen species (ROS) and elevate ROS production by consuming endogenous GSH and promoting electron-hole pair separation. The synthesized nanoribbons showed excellent computed tomography imaging of tumors and significant tumor suppression in vitro and in vivo, demonstrating a potential two-step enhancement SDT process activated by endogenous GSH and amplified by exogenous ultrasound.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jie Li et al.
Summary: This study presents a new strategy to increase photothermal conversion efficiency by transforming photothermal agents from aggregated state to dispersed state, improving the therapeutic performance of photothermal therapy. By releasing photothermal molecules from nanoparticles to achieve state transformation, a distinct photothermal therapeutic performance for cancer ablation can be demonstrated in lysosome of cancer cells.
ADVANCED MATERIALS
(2021)
Article
Engineering, Environmental
Qianqian Sun et al.
Summary: The study designed a Ca2+ nanogenerator that reshapes the tumor microenvironment through heat generation of indocyanine green and production of copper ions, enabling photodynamic therapy, chemodynamic therapy, and calcium overload. The generation of Ca(OH)2 during the reaction significantly improves the acidic environment of TME and promotes the oxidation of GSH.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Jian Sun et al.
Summary: In this study, a unimolecular glutathione and light coactivatable photosensitizer targeting mitochondria was developed, demonstrating high performance PDT effect through type I, type II reactions, and secondary radicals-participating reactions. With a relatively large two-photon absorption cross section for photoexcitation, the new photosensitizing system shows promising applications in both normoxic and hypoxic environments.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Multidisciplinary
Shuang Bai et al.
Summary: The first generation of nanomedicine shows superior performance compared to traditional anticancer therapeutics in clinical treatment of cancer, but poor tumor penetration has been a major obstacle. Recently, smart size shrinkable drug delivery nanosystems have effectively improved this situation by maintaining a relatively large size in circulation system and turning into smaller particles at the tumor site to enhance tumor penetration.
Article
Chemistry, Multidisciplinary
Yuanbo Wang et al.
Summary: This study presents a cancer-cell-activated photosensitizer synthesis strategy to selectively synthesize efficient PS with mitochondria-targeting capability for potent cancer-cell-specific ablation under light irradiation, ensuring high specificity and safety for post-treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Brian K. Wilson et al.
Summary: The hypothesis states that DLS-generated PSD of polymer-stabilized nanoparticles is dependent on the optimization parameters used for inversion solution fit. By comparing TEM images with DLS results, the accuracy of the DLS PSD and polydispersity can be determined. The experiments show that DLS consistently overestimates the standard deviation of the PSD compared to TEM measurements.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Editorial Material
Multidisciplinary Sciences
Virginia Gewin et al.
Summary: Silvia Giordani hopes that nanoparticles carrying chemotherapeutic drugs could help cancer patients avoid some of the side effects of the drugs.
Article
Chemistry, Multidisciplinary
Yafeng Wu et al.
Summary: A versatile nanoprobe (H-MnO2/DOX/BPQDs) was developed for dual-modality cancer imaging and synergistic chemo-phototherapy, utilizing the distinct characteristics of black phosphorus quantum dots (BPQDs). The designed nanoprobe displayed dual-modality MRI/FL imaging and synergistic chemotherapy/PDT/PTT, ultimately enhancing the accuracy of cancer diagnosis and therapeutic performance.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Kuikun Yang et al.
Summary: A supramolecular nanoparticle has been developed for chemodynamic therapy, which can release radicals and platinum (IV) prodrug in tumors to enhance H2O2 generation. The nanoparticles can be readily excreted via renal clearance to avoid systemic toxicity, providing potential for novel cascade chemo/chemodynamic therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Xianwen Wang et al.
Summary: Inorganic nanomaterials have great potential in biomedicine, but long-term accumulation in healthy tissues can cause toxicity. The emergence of biodegradable and clearable inorganic nanomaterials provides a way to prevent such toxicity, and a comprehensive understanding of their design and metabolic pathways is essential for expanding therapeutic applications for various diseases.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Cell & Tissue Engineering
Michael Ruckert et al.
Summary: Radiotherapy aims to achieve local tumor control by inducing DNA damage, with immunological effects that can be both stimulatory and suppressive. Immunotherapies can be combined with radiotherapy to enhance antitumor immune responses or counteract radiotherapy-induced immunosuppression.
Review
Chemistry, Multidisciplinary
Yuxuan Xiong et al.
Summary: The combination of nanomedicine with GSH scavenging agents and therapeutic drugs has attracted significant interest in enhancing cancer treatment outcomes. Despite unsatisfactory results, this approach has shown promising results in a large number of rodent tumor models.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Physical
Sumit Kumar et al.
APPLIED SURFACE SCIENCE
(2020)
Review
Critical Care Medicine
Adrien Mirouse et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Chemistry, Physical
Roger M. Pallares et al.
Review
Oncology
Xingshu Li et al.
NATURE REVIEWS CLINICAL ONCOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Guangxue Feng et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Review
Chemistry, Multidisciplinary
Pui-Chi Lo et al.
CHEMICAL SOCIETY REVIEWS
(2020)
Article
Chemistry, Multidisciplinary
Jun Yang et al.
Article
Chemistry, Multidisciplinary
Si Wu et al.
Article
Biotechnology & Applied Microbiology
Chen Du et al.
JOURNAL OF NANOBIOTECHNOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Huijing Xiang et al.
ACS APPLIED MATERIALS & INTERFACES
(2018)
Review
Chemistry, Multidisciplinary
Luodan Yu et al.
ADVANCED MATERIALS
(2018)
Article
Chemistry, Multidisciplinary
Dandan Ding et al.
Article
Chemistry, Multidisciplinary
Song Shen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Review
Oncology
Samer Tohme et al.
Article
Chemistry, Multidisciplinary
Xuejiao Song et al.
Article
Multidisciplinary Sciences
Yuhao Cheng et al.
NATURE COMMUNICATIONS
(2015)
